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SLC6A5 encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. Additionally we are shipping SLC6A5 Proteins (7) and many more products for this protein.
Showing 10 out of 15 products:
Rat (Rattus) Polyclonal SLC6A5 Primary Antibody for IP, IHC - ABIN1742533
Sunagawa, Shimizu-Okabe, Kim, Kobayashi, Kosaka, Yanagawa, Matsushita, Okabe, Takayama: Distinct development of the glycinergic terminals in the ventral and dorsal horns of the mouse cervical spinal cord. in Neuroscience 2016
that the deletion of VIAAT (show SLC32A1 Antibodies) in GlyT2-Cre expressing neurons also strongly affects GABAergic transmission
Results suggest that the excessive GAT-1 (show SLC6A1 Antibodies) and GlyT-1 (show GLYT1 Antibodies)/2 heterotransporter-mediated Glu (show GCG Antibodies) release, in the spinal cord of SOD1 (show SOD1 Antibodies)(G93A) mice, is due to the heterotransporter over-expression at the nerve terminal membrane, promoted by the excessive Glu (show GCG Antibodies) exocytosis
Report that in the presence of a GlyT2 mechanism-based toxicity, reversible inhibitors might allow a tolerable balance between efficacy and toxicity.
These alterations in the activities and expression profiles of the GlyTs suggest that the contributions of GlyT1 (show GLYT1 Antibodies) and GlyT2 to the regulation of extracellular glycine concentrations at glycinergic synapses changes during development.
Data show that the GlyT2 protein is undetectable in homozygous mutants, indicating a null allele.
In the first postnatal week, loss of the glycine transporter 2 is neither compensated by glycine de-novo synthesis nor by up-regulation of the GABAergic transmission in GlyT2(-/-) mice.
These data indicate that the C-terminal PDZ (show INADL Antibodies)-ligand motif of GlyT2 plays an important role in transporter trafficking to and/or stabilization at synaptic sites.
Glyt2-mediated release of glycine from axon terminals involves exocytosis triggered by intraterminal mitochondrial Ca2 (show CA2 Antibodies)+ ions.
our results demonstrate the central role played by GlyT2 in determining inhibitory phenotype and therefore in the physiology and pathology of inhibitory circuits.
analysis of the human SLC6A5 (show SLC6A2 Antibodies) gene mutation associated with hyperekplexia
Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster.
A novel dominant hyperekplexia mutation Y705C alters trafficking and biochemical properties of the presynaptic glycine transporter GlyT2.
This study firmly establishes the combination of missense, nonsense, frameshift, and splice site mutations in the GlyT2 gene as the second major cause of startle disease.
A transgenic cell line is studied in which green fluorescent protein (GFP) is expressed under the control of the promoter for the glycine transporter GlyT2 during zebrafish development.
Inspiratory-modulated neurons with pacemaker properties are present in the preBotzinger complex of newborn transgenic mice and express the glycine tranporter (GlyT)2 protein.
SLC6A5 (show SLC6A2 Antibodies) mutations result in defective subcellular GlyT2 localization, decreased glycine uptake or both, with selected mutations affecting predicted glycine and Na+ binding sites.
results are consistent with GLYT2 being a disease gene in human hyperekplexia
SLC6A5 (show SLC6A2 Antibodies) gene is associated with schizophrenia.
This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia\; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea.
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
, sodium- and chloride-dependent glycine transporter 2-like
, glycine transporter 2
, sodium- and chloride-dependent glycine transporter 2
, solute carrier family 6 member 5