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Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 Proteins (SLC6A2)

SLC6A2 encodes a member of the sodium symporter family. Additionally we are shipping SLC6A2 Antibodies (27) and SLC6A2 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC6A2 20538 O55192
SLC6A2 83511  
SLC6A2 6530 P23975
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Top SLC6A2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

SLC6A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus)
Human ,

More Proteins for Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 (SLC6A2) Interaction Partners

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 (SLC6A2) interaction partners

  1. Differences in gene expression in the mouse frontal cortex with life-long norepinephrine transporter knock-out were studied using a whole-genome microarray approach

  2. inhibition of p38 MAPK (show MAPK14 Proteins) or the manipulation of NET-Thr (show TRH Proteins)(30) motif/phosphorylation via a TAT (show TAT Proteins) peptide strategy prevents cocaine-induced NET up-regulation, locomotor sensitization, and conditioned place preference

  3. this is the first report which suggests the beneficial effect of modulation of TRPV1 (show TRPV1 Proteins) receptors and NET in Chronic cerebral hypoperfusion vascular dementia

  4. Norepinephrine transporter has a greater role in determining baseline analgesia and other analgesic effects in mice than serotonin transporter (show SLC6A4 Proteins).

  5. NET expression is essential for development and/or survival of some (5-HT (show DDC Proteins)- and calretinin (show CALB2 Proteins)-expressing), but not all (nNOS (show NOS1 Proteins)-expressing), of these neurons.

  6. propose that amplified norepinephrine transporter function in rictor KO mice enhances accumulation of both norepinephrine and dopamine within the noradrenergic neuron

  7. We identified that gene expression in neuronal cortical cells involves increased histone hyperacetylation on the Slc6a2 promoter, which is commensurate with the recruitment of SP1 and RNA Polymerase II and is inversely correlated with H3K9 trimethylation.

  8. Data demonstrate that estrogen exerts significant modulatory effects on olfactory bulb function through modulation of tyrosine hydroxylase (show TH Proteins), dopamine transporter and norepinephrine transporter expression.

  9. this is the first report to suggest that the norepinephrine transporter gene is one of many possible genetic factors influencing ethanol sensitivity in ILS, ISS, and LXS RI mouse strains

  10. The effects of DAT (show SLC6A3 Proteins) KO in animal models of depression are larger than those produced by NET or SERT (show SLC6A4 Proteins) KO, and unlikely to be simply the result of the confounding effects of locomotor hyperactivity.

Human Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 (SLC6A2) interaction partners

  1. NET undergoes extensive constitutive internalization and internalized NET mainly is sorted to Rab11-positive recycling endosomes.

  2. In Major Depressive Disorder patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.

  3. This corticotropin releasing factor (show CRH Proteins)-induced regulation on norepinephrine transporter expression and function may play a role in development of stress-related depression and anxiety

  4. a NET 182C and 5-HTTLPR (show SLC6A4 Proteins) polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients

  5. NET gene variants are not involved in the etiology of recurrent major depressive disorder in Chinese Han population.

  6. A Cox (show COX8A Proteins) regression analysis for remission incidence during the 8-week treatment course significantly depends on SLC6A2 variants (rs28386840, rs40434, and rs187714)from major depression after venlafaxine treatment.

  7. The response to venlafaxine was assessed after 4 weeks of treatment and correlated to serum concentration and functional variants in genes encoding SLC6A2 and SLC6A4 (show SLC6A4 Proteins)

  8. polymorphisms of 1287G/A, -182T/C and -3081A/T in the norepinephrine transporter gene are not risk factors in alcohol dependence.

  9. The results of this study do not support the association between the SLC6A2 and the diagnosis or phenotype of autism spectrum disorder.

  10. results do not indicate involvement of changes in brain Norepinephrine Transporter availability or distribution in the pathogenesis of Attention deficit/hyperactivity disorder.

SLC6A2 Protein Profile

Protein Summary

This gene encodes a member of the sodium symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Gene names and symbols associated with SLC6A2

  • solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (SLC6A2)
  • solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (Slc6a2)
  • solute carrier family 6 (neurotransmitter transporter), member 2 (Slc6a2)
  • solute carrier family 6 (neurotransmitter transporter), member 2 (SLC6A2)
  • NAT1 protein
  • NE-T protein
  • Net protein
  • NET1 protein
  • SLC6A2 protein
  • Slc6a5 protein

Protein level used designations for SLC6A2

solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 , norepinephrine plasma membrane transporter , pulmonary norepinephrine plasma membrane transporter , solute carrier family 6 member 2 , sodium-dependent noradrenaline transporter-like , sodium- and chloride-dependent glycine transporter 2-like , solute carrier family 6 (neurotransmitter transporter, glycine), member 5 , NE transporter , norepinephrine transporter , sodium-dependent noradrenaline transporter , NET , NaCl-dependent norepinephrine transporter , neurotransmitter transporter, noradrenal , transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157 , neurotransmitter transporter , solute carrier family 6 member 5

GENE ID SPECIES
443100 Ovis aries
454096 Pan troglodytes
100061346 Equus caballus
100388661 Callithrix jacchus
100465372 Ailuropoda melanoleuca
100521246 Sus scrofa
100549466 Meleagris gallopavo
100598446 Nomascus leucogenys
20538 Mus musculus
282363 Bos taurus
395458 Gallus gallus
487272 Canis lupus familiaris
83511 Rattus norvegicus
6530 Homo sapiens
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