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SLC6A4 encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. Additionally we are shipping Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Kits (37) and Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins (5) and many more products for this protein.
Showing 10 out of 102 products:
Human Polyclonal SLC6A4 Primary Antibody for IEM, ICC - ABIN617913
Sur, Betz, Schloss: Localization of the serotonin transporter in rat spinal cord. in The European journal of neuroscience 1997
Show all 60 references for ABIN617913
Human Polyclonal SLC6A4 Primary Antibody for IF (p), IHC (p) - ABIN735983
Wang, Liu, Wang, Bai, Zhang, Sun, Wang: Involvement of serotonin mechanism in methamphetamine-induced chronic pulmonary toxicity in rats. in Human & experimental toxicology 2013
Show all 5 references for ABIN735983
Human Polyclonal SLC6A4 Primary Antibody for ELISA, WB - ABIN185394
Voeller: Attention-deficit hyperactivity disorder (ADHD). in Journal of child neurology 2004
Show all 3 references for ABIN185394
These data suggest that a small number of neurons selectively express factor(s) required for 5-HT (show DDC Antibodies) storage, and potentially for function of dSERT.
Results suggest a novel mechanism through which increased expression of the 5-HTT gene can alter the microcircuitry of the amygdala
miR (show MLXIP Antibodies)-24 played a role in the pathogenesis of IBS probably through regulating SERT expression.
Results reveal dissimilarities in adult behavior and neurotransmission arising from developmental exposure to different widely prescribed antidepressants that are not recapitulated by genetic SERT insufficiency
Increased 5-HTT expression reduces negative cognitive bias for stimuli with uncertain outcomes.
Cohabitation with a female (mating experience) reduced anxiety-like behavior and increased exploratory locomotion in the open field test in male heterozygous 5-HTT knockout mice but did not affect wildtype mice
The serotonin transporter gene (5-HTT/SLC6A4)-linked polymorphic region (5-HTTLPR) is assumed to modulate the interaction between developmental stress exposure and emotional dysregulation later in life.
This study demonstrated that the cell signaling level, probably contributes to the moderation of the anxiety phenotype in 5-HTT(-/-) mice.
Results show that increased 5-HTT expression has some maladaptive effects on reinforcement learning, supporting recent suggestions that l allele homozygosity may be a potential risk factor for disabling psychiatric traits
This study finding of a correlation between SERT and c-FOS protein expression affected by PS, together with related mRNAs.
The interaction between SERT and alphaCaMKII was confirmed in serotonergic neurons where they are colocalized.
This paper contains kinetics data of serotonin receptor (show HTR1B Antibodies) binding.
An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.
Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.
A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor (show HTR1A Antibodies) site is found in animals possessing this polymorphism.
We find that the short allele of the rh5 (show RHO Antibodies)-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.
rh5 (show RHO Antibodies)-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.
short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.
carriers of the low-expressing rh5 (show RHO Antibodies)-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.
evidence that the short allelic variant in rh5 (show RHO Antibodies)-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants
this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors
Data sho (show SPRN Antibodies) wthat genotype (serotonin transporter promoter) acted independently in interaction with social condition to affect behavioral responses.
This study aimed to explore the relationship between premature ejaculation (PE) and the serotonin transporter gene-linked polymorphic region (5-HTTLPR) with respect to the biallelic and triallelic classifications.No significant difference regarding biallelic 5-HTTLPR.Found a significantly lower frequency of the L'L' genotype (OR=0.37; 95%CI=0.15-0.91, P=0.025) in patients with LPE. Triallelic 5-HTTLPR associated with LPE.
The interaction between 5-HTT (LL) and BDNF (A (show BDNF Antibodies)+) increased the risk of anxiety, and the interaction between BDNF (A (show BDNF Antibodies)+, GG) and NPSR1 (show NPSR1 Antibodies) (AA, T+) increased the risk of depression in asthmatic patients.
This study provided preliminary support for the SLC6A4 HTTLPR polymorphism as potential modifier of desvenlafaxine efficacy.
5-HTTLPR was not a high-risk susceptible gene in SLE but might relate to SLE by affecting production of some autoantibodies, especially anti-Sm and anti-U1RNP (show SNRNP70 Antibodies) antibody.
The LL genotype and LALA haplotype of SLC6A4 are associated with favorable treatment response to fluoxetine in south Indian major depression patients.
A robust association was found between the 5-HTTLPR/rs25531 polymorphism and facial emotion perception. There was no association between the 5-HTTLPR/rs25531 polymorphism and non-social abilities.
5-HTTLPR had an independent, variant dosage effect on self-directed aggression in Italian prisoners.
5-HTTLPR short allele carriers with ADHD showed the least reward speeding when exposed to high positive peer affiliation, but the most when faced with low positive peer affiliation or low maternal warmth.
Variation in the 5-HTTLPR was characterized via haplotype, using two single nucleotide polymorphisms (SNPs). Overall, results show a main effect of recent stress for all ethnic groups, and mixed results for the variation in 5-HTTLPR x stress interaction, contingent upon statistical model used. Findings suggest there may be a differential effect of stressors and 5-HTTLPR on depressive symptoms by ethnicity
Resequencing three candidate genes (HOMER1 (show HOMER1 Antibodies), SLC6A4, and TEF (show TEF Antibodies)) discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese.
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
, drosophila serotonin transporter
, cocaine-sensitive serotonin transporter
, sodium-dependent serotonin transporter
, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
, solute carrier family 6 member 4
, sodium-dependent serotonin transporter-like
, plasma membrane transporter for serotonin reuptake
, 5-hydroxytryptamine (serotonin) transporter
, 5HT transporter
, Sodium-dependent serotonin transporter (5HT transporter) (5HTT)
, transmembrane 5-HT transporter
, 5-hydroxytryptamine transporter
, Na+/Cl- dependent serotonin transporter
, serotonin transporter 1
, Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)
, solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)
, solute carrier family 6, member 4
, serotnin transporter