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Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins (SLC6A4)

SLC6A4 encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. Additionally we are shipping Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Antibodies (96) and Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC6A4 15567 Q60857
SLC6A4 6532 P31645
Rat SLC6A4 SLC6A4 25553 P31652
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Top Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
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SLC6A4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

Top referenced Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins

  1. Human SLC6A4 Protein expressed in Human - ABIN2732177 : Savy, Fitchett, McQuade, Gartside, Morris, Blain, Judge: Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour. in Neurotoxicology 2015 (PubMed)

More Proteins for Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaction Partners

Fruit Fly (Drosophila melanogaster) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT (show DDC Proteins) storage, and potentially for function of dSERT.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Results suggest a novel mechanism through which increased expression of the 5-HTT gene can alter the microcircuitry of the amygdala

  2. miR (show MLXIP Proteins)-24 played a role in the pathogenesis of IBS probably through regulating SERT expression.

  3. Results reveal dissimilarities in adult behavior and neurotransmission arising from developmental exposure to different widely prescribed antidepressants that are not recapitulated by genetic SERT insufficiency

  4. Increased 5-HTT expression reduces negative cognitive bias for stimuli with uncertain outcomes.

  5. Cohabitation with a female (mating experience) reduced anxiety-like behavior and increased exploratory locomotion in the open field test in male heterozygous 5-HTT knockout mice but did not affect wildtype mice

  6. The serotonin transporter gene (5-HTT/SLC6A4)-linked polymorphic region (5-HTTLPR) is assumed to modulate the interaction between developmental stress exposure and emotional dysregulation later in life.

  7. This study demonstrated that the cell signaling level, probably contributes to the moderation of the anxiety phenotype in 5-HTT(-/-) mice.

  8. Results show that increased 5-HTT expression has some maladaptive effects on reinforcement learning, supporting recent suggestions that l allele homozygosity may be a potential risk factor for disabling psychiatric traits

  9. This study finding of a correlation between SERT and c-FOS protein expression affected by PS, together with related mRNAs.

  10. The interaction between SERT and alphaCaMKII was confirmed in serotonergic neurons where they are colocalized.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. This paper contains kinetics data of serotonin receptor (show HTR1B Proteins) binding.

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.

  2. Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.

  3. A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor (show HTR1A Proteins) site is found in animals possessing this polymorphism.

  4. We find that the short allele of the rh5-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.

  5. rh5-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.

  6. short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.

  7. carriers of the low-expressing rh5-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.

  8. evidence that the short allelic variant in rh5-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants

  9. this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors

  10. Data sho (show SPRN Proteins) wthat genotype (serotonin transporter promoter) acted independently in interaction with social condition to affect behavioral responses.

Human Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Variation in the 5-HTTLPR was characterized via haplotype, using two single nucleotide polymorphisms (SNPs). Overall, results show a main effect of recent stress for all ethnic groups, and mixed results for the variation in 5-HTTLPR x stress interaction, contingent upon statistical model used. Findings suggest there may be a differential effect of stressors and 5-HTTLPR on depressive symptoms by ethnicity

  2. Resequencing three candidate genes (HOMER1 (show HOMER1 Proteins), SLC6A4, and TEF (show TEF Proteins)) discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese.

  3. The genetic-interactions among BMPR-2 (show BMPR2 Proteins), ALK-1 (show ACVRL1 Proteins), and 5-HTT polymorphisms, elevated BMP-2 (show BMP2 Proteins) and 5-HT (show DDC Proteins) levels and differential gene expression substantiated the strong genetic contribution in high altitude pulmonary edema pathophysiology.

  4. Panic patients with 5HT transporter Na+/Cl- dependent serotonin transporter short (S) alleles showed a trend to be associated with poorer general health compared to L' carriers.

  5. 5-HTTLPR is a functional repeat length polymorphism influencing serotonin reuptake efficiency and consequently serotonin availability in the synaptic cleft in the central nervous system.

  6. Findings confirm an association between tumour necrosis factor-alpha (show TNF Proteins) and serotonin transporter in both the basal physiological and pathological condition.

  7. In a dataset of African American children, higher residential instability, in conjunction with the risk variant of 5-HTTLPR (i.e., the short allele), was associated with the highest level and steepest gradient of growth in substance use across ages 10-24 years.

  8. Whether the SERT availability in the brain is altered in smokers remains unclear.

  9. Child abuse moderates the relation of the serotonin transporter gene to stress generation.

  10. Results suggest a role of the 5-HTTLPR genotype in fearful dyspnea anticipation.

Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Protein Profile

Protein Summary

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Gene names and symbols associated with SLC6A4

  • Serotonin transporter (SerT)
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4)
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (slc6a4)
  • serotonin transporter (SERT)
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4)
  • solute carrier family 6 (neurotransmitter transporter), member 4 (SLC6A4)
  • solute carrier family 6 (neurotransmitter transporter), member 4 (Slc6a4)
  • 5-HTT protein
  • 5-HTTLPR protein
  • 5HTT protein
  • AI323329 protein
  • CG4545 protein
  • Dmel\\CG4545 protein
  • DmSerT protein
  • dsert protein
  • dSERT1 protein
  • hSERT protein
  • Htt protein
  • OCD1 protein
  • Sert protein
  • SERT1 protein
  • SLC6A4 protein

Protein level used designations for SLC6A4

serotonin transporter , CG4545-PA , SerT-PA , drosophila serotonin transporter , cocaine-sensitive serotonin transporter , sodium-dependent serotonin transporter , solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 , solute carrier family 6 member 4 , sodium-dependent serotonin transporter-like , huntingtin , plasma membrane transporter for serotonin reuptake , 5-hydroxytryptamine (serotonin) transporter , 5HT transporter , 5HTT , Sodium-dependent serotonin transporter (5HT transporter) (5HTT) , transmembrane 5-HT transporter , 5-hydroxytryptamine transporter , Na+/Cl- dependent serotonin transporter , serotonin transporter 1 , Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6, member 4 , serotnin transporter

GENE ID SPECIES
37895 Drosophila melanogaster
404747 Gallus gallus
468201 Pan troglodytes
100340600 Oryctolagus cuniculus
100396167 Callithrix jacchus
100435954 Pongo abelii
100540532 Meleagris gallopavo
100562250 Anolis carolinensis
100596376 Nomascus leucogenys
443491 Ovis aries
15567 Mus musculus
282365 Bos taurus
100135619 Cavia porcellus
574140 Macaca mulatta
6532 Homo sapiens
25553 Rattus norvegicus
491184 Canis lupus familiaris
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