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Transports betaine and GABA. Additionally we are shipping SLC6A12 Antibodies (38) and and many more products for this protein.
Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13 (show SLC6A13 ELISA Kits)) gene in mice leads to changes in liver and brain taurine contents.
This study suggests that BGT1 plays its main role in the liver, thereby complementing other betaine-transporting carrier proteins (e.g., slc6a20 (show SLC6A20 ELISA Kits)) that are predominantly expressed in the small intestine or kidney rather than the liver.
Mice lacking exons 3-5 of the BGT1 gene have normal development & show seizure susceptibility indistinguishable from wild-type in a variety of seizure threshold models. This does not support a role for BGT1 in the control of seizure susceptibility.
The SLC6A12 expression levels in peripheral blood mononuclear cells were significantly higher in TLE patients.
T40 may be important for the trafficking and insertion of BGT1 in the plasma membrane
JAK2 (show JAK2 ELISA Kits) is a novel regulator of the GABA transporter BGT1.
This study found that rs216250 of SLC6A12 was correlated with the Scale for the Assessment of Negative Symptoms (SANS (show USH1G ELISA Kits)) scores.
Results showed that two polymorphisms and a haplotype in SLC6A12, were significantly associated with AIA after multiple testing corrections.
The primary structure of BGT-1 predicts two putative phosphorylation sites for the Ca2 (show CA2 ELISA Kits)+/diacylglycerol-dependent protein kinase (show CDK7 ELISA Kits) (PKC), which regulates BGT-1 function by phosphorylation events in a transport system expressed in cultured astrocytoma cells.
BGT-1 is expressed from mRNA and transports GABA in platelets.
Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
sodium- and chloride-dependent betaine transporter
, solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
, solute carrier family 6 (neurotransmitter transporter, GABA), member 13
, sodium- and chloride-dependent betaine transporter-like
, Na(+)/Cl(-) betaine/GABA transporter
, gamma-aminobutyric acid (GABA-A) transporter 2
, sodium- and chloride-dependent GABA transporter 2
, solute carrier family 6 member 12
, Betain-GABA transporter
, Na+- and Cl- dependent betaine transporter
, betaine gamma-amino-n-butyric acid transporter
, Na and Cl dependent betaine transporter
, Betaine/GABA transporter 1
, GABA transporter 1
, vesicular GABA transporter
, betaine/GABA transporter-1
, gamma-aminobutyric acid transporter