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anti-Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) Antibodies

SLC7A11 encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. Additionally we are shipping SLC7A11 Kits (8) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC7A11 23657 Q9UPY5
SLC7A11 310392  
SLC7A11 26570 Q9WTR6
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Top anti-SLC7A11 Antibodies at antibodies-online.com

Showing 10 out of 87 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Goat Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB ABIN190899 (0.02µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated FACS, ICC, IF, IHC, IHC (p), SimWes, WB Detection of XCT in total human and mouse stomach lysate, respectively, using ABIN152648.  1 minute ECL exposure. XCT staining in the absorptive epithelia of intestinal villi detected using ABIN152648. 0.025 mL Log in to see 5 to 7 Days
$203.44
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SLC7A11 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Biotin IHC (p), IHC, WB   0.1 mL Log in to see 5 to 7 Days
$391.13
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human brain labeled with Anti-CCBR1 Polyclonal Antibody, Unconjugated (ABIN872924) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human kidney labeled with Anti-CCBR1 Polyclonal Antibody, Unconjugated (ABIN872924) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit HRP IHC (p), IHC, WB   0.1 mL Log in to see 5 to 7 Days
$427.88
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details

SLC7A11 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SLC7A11 Antibodies

  1. Dog (Canine) Polyclonal SLC7A11 Primary Antibody for IHC (p), WB - ABIN374804 : Olm, Fernandes, Hebert, Rundlöf, Larsen, Danielsson, Björnstedt: Extracellular thiol-assisted selenium uptake dependent on the x(c)- cystine transporter explains the cancer-specific cytotoxicity of selenite. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)
    Show all 2 references for ABIN374804

  2. Human Polyclonal SLC7A11 Primary Antibody for ELISA, WB - ABIN190899 : Kaleeba, Berger: Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT. in Science (New York, N.Y.) 2006 (PubMed)

More Antibodies against SLC7A11 Interaction Partners

Human Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) interaction partners

  1. Study demonstrated that the mRNA expression levels of the two system xc- subunits, SLC7A11 and SLC3A2 (show SLC3A2 Antibodies), in peripheral white blood cells are lowered in patients with schizophrenia than healthy individuals

  2. the rate of cystine uptake was significantly faster than the rate of glutamate (show GRIN1 Antibodies) release in human glioma cells.

  3. increased SLC7A11 expression predicted shorter malignant glioma patient survival.

  4. We discovered that many genes involved in oxidative stress/antioxidant defense system, apoptosis/anti-apoptosis/cell death, and cellular response to unfolded proteins/topologically incorrect proteins are potentially regulated by xCT.

  5. Data indicate that cystine-glutamate (show GRIN1 Antibodies) exchange transporter protein (show HNRNPU Antibodies) SLC7A11 mRNA is regulated by cellular stress and nonsense-mediated RNA decay (NMD).

  6. These observations suggest that the expression of xCT in esophageal squamous cell carcinoma (ESCC) cells might affect the G1/S checkpoint and impact on the prognosis of ESCC patients

  7. Our findings indicate that miRNA-27a negatively regulates SLC7A11 in cisplatin-resistant bladder cancer, and shows promise as a marker for patients likely to benefit from cisplatin-based chemotherapy

  8. Results show that Nrf2 (show GABPA Antibodies) and ATF4 (show ATF4 Antibodies) were upregulated by proteasome inhibition and cooperatively enhance human xCT gene expression upon proteasome inhibition.

  9. IGF-I (show IGF1 Antibodies) regulates cystine uptake and cellular redox status by activating the expression and function of xCT in estrogen receptor (show ESR1 Antibodies)-positive (ER(+)) breast cancer cells by a mechanism that relies on the IGF receptor substrate-1 (IRS-1 (show IRS1 Antibodies)).

  10. the xCT antiporter, which is expressed on one-third of triple-negative breast tumors in this study, may have a role in glutamine (show GFPT1 Antibodies) updake and dependence

Mouse (Murine) Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) interaction partners

  1. Protein expression of xCT was observed throughout the forebrain and amygdala.

  2. Cerebellar astroglia isolated from Atm (show ATM Antibodies) mutant mice show decreased expression of the cystine/glutamate (show GRIN1 Antibodies) exchanger subunit xCT, glutathione reductase (show GSR Antibodies), and glutathione-S-transferase (show GSTa2 Antibodies)

  3. IL-1beta (show IL1B Antibodies) increases the level of mRNA encoding xCT in primary cultures of astrocytes isolated from mouse cortex.

  4. Study found that aglycemic neuronal cell death does not result from changes in astrocyte system xc- expression or activity or from impairment of glutamate (show GRIN1 Antibodies) removal

  5. This study indicated that, under physiological conditions, nonvesicular glutamate (show GRIN1 Antibodies) release via system xc- mediates aspects of higher brain function related to anxiety and depression, but does not influence sensorimotor function or spatial vision

  6. The study supports a novel role for the Slc7a11 in mediating T cell infiltration into the CNS as well as promoting myelin destruction after immune cell infiltration in experimental autoimmune encephalomyelitis.

  7. glutamate (show GRIN1 Antibodies) released by the cystine/glutamate (show GRIN1 Antibodies) antiporter activated extrasynaptic, but not synaptic, NMDARs, and blockade of extrasynaptic NMDARs reduced ischemia-gated currents and cell damage after oxygen and glucose deprivation

  8. In xCT knock-out mice, synapses showed increased spontaneous and evoked synaptic transmission.

  9. mutant mice of slc7a11 demonstrate deficits in four-arm and three-arm spontaneous alternation tasks, and glutamate (show GRIN1 Antibodies) level increase in striatium.

  10. xCT contributes to the maintenance of glutathione levels in lungs and the glutathione redox state as a protective system during oxidative stress.

SLC7A11 Antigen Profile

Protein Summary

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Gene names and symbols associated with SLC7A11

  • solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 (SLC7A11) antibody
  • solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 (SLC7A11) antibody
  • solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 (Slc7a11) antibody
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (Slc7a11) antibody
  • 9930009M05Rik antibody
  • AI451155 antibody
  • CCBR1 antibody
  • DKFZp468E122 antibody
  • SLC7A11 antibody
  • sut antibody
  • xCT antibody

Protein level used designations for SLC7A11

solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 , cystine/glutamate transporter , solute carrier family 7, member 11 , Cystine/glutamate transporter , cystine/glutamate transporter-like , solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 , amino acid transport system xc- , calcium channel blocker resistance protein CCBR1 , solute carrier family 7 member 11 , solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 , cysteine/glutamate transporter , sodium independent anionic amino acid transport system

GENE ID SPECIES
428731 Gallus gallus
471310 Pan troglodytes
524078 Bos taurus
696516 Macaca mulatta
100027770 Monodelphis domestica
100049683 Sus scrofa
100091177 Ornithorhynchus anatinus
100172659 Pongo abelii
100386974 Callithrix jacchus
100581045 Nomascus leucogenys
23657 Homo sapiens
310392 Rattus norvegicus
483821 Canis lupus familiaris
26570 Mus musculus
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