Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) ELISA Kits

SLC7A11 encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. Additionally we are shipping SLC7A11 Antibodies (103) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SLC7A11 23657 Q9UPY5
SLC7A11 310392  
SLC7A11 26570 Q9WTR6
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Top SLC7A11 ELISA Kits at antibodies-online.com

Showing 5 out of 12 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Rat 0.55 1.56-100 ng/mL 96 Tests Log in to see 13 to 16 Days
$640.00
Details
Human 4.68 pg/mL 18.75-1200 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details
Human 0.078 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 2 to 3 Days
$713.90
Details
Mouse 0.156-10 ng/mL   96 Tests Log in to see 2 to 3 Days
$867.90
Details
Mouse
0.156-10 ng/mL   96 Tests Log in to see 15 to 18 Days
$1,029.60
Details

More ELISA Kits for SLC7A11 Interaction Partners

Human Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) interaction partners

  1. ARF inhibits tumor growth by suppressing the ability of NRF2 (show GABPA ELISA Kits) to transcriptionally activate its target genes, including SLC7A11, a component of the cystine/glutamate (show GRIN1 ELISA Kits) antiporter that regulates reactive oxygen species (ROS (show ROS1 ELISA Kits))-induced ferroptosis.

  2. Mechanistically, CD44v interacts with and stabilizes xCT and thereby promotes the uptake of cysteine for glutathione synthesis and stimulates side-population cell enrichment.

  3. ATF4 (show ATF4 ELISA Kits) expression fosters the malignancy of primary brain tumors and increases proliferation and tumor angiogenesis; experiments revealed that ATF4 (show ATF4 ELISA Kits)-dependent tumor promoting effects are mediated by transcriptional targeting the glutamate (show GRIN1 ELISA Kits) antiporter xCT

  4. Identify mTORC2 (show CRTC2 ELISA Kits) as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate (show GRIN1 ELISA Kits) antiporter xCT. mTORC2 (show CRTC2 ELISA Kits) phosphorylates serine 26 at the cytosolic N terminus of xCT, inhibiting its activity.

  5. Data suggest that glucose starvation of various neoplasm cell lines induces SLC7A11 expression; SLC7A11 overexpression decreases intracellular glutamate (show GRIN1 ELISA Kits), an alternative source of metabolic energy; provision of alpha-ketoglutarate, a key downstream metabolite of glutamate (show GRIN1 ELISA Kits), restores survival in SLC7A11-overexpressing neoplasm cell lines under glucose starvation.

  6. Results suggest that expression of SLC7A11 in the context of glioma contributes to tumorigenesis, tumor progression, and resistance to standard chemotherapy.

  7. High SLC7A11 expression is associated with glioma.

  8. The most frequent SLC7A7 (show Slc7a7 ELISA Kits) mutation in Japanese LPI (show Slc7a7 ELISA Kits) patients is p.R410*, which is a founder effect mutation in northern Japan.

  9. While the transsulfuration pathway plays a primary role in supplying Cys (show DNAJC5 ELISA Kits) to the redox system in the liver, xCT is induced in cases of emergencies, by compensating for Cys (show DNAJC5 ELISA Kits) supply systems.

  10. Although LCN2 (show LCN2 ELISA Kits) increased intracellular iron concentrations, LCN2 (show LCN2 ELISA Kits)-induced GSH may catalyze and override oxidative stress via CD44 (show CD44 ELISA Kits) and xCT, and subsequently enhance the survival of clear cell carcinoma tumor cells in oxidative stress-rich environment.

Mouse (Murine) Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) interaction partners

  1. ARF inhibits tumor growth by suppressing the ability of NRF2 (show NFE2L2 ELISA Kits) to transcriptionally activate its target genes, including SLC7A11, a component of the cystine/glutamate (show GRIN1 ELISA Kits) antiporter that regulates reactive oxygen species (ROS (show ROS1 ELISA Kits))-induced ferroptosis.

  2. Expression of xCT is reduced in astroglia in a genetic mouse model of susceptibility to depressive-like behavior.

  3. Data suggest that glucose starvation of various neoplasm cell lines induces Slc7a11 expression; Slc7a11 overexpression decreases intracellular glutamate (show GRIN1 ELISA Kits), an alternative source of metabolic energy; provision of alpha-ketoglutarate, a key downstream metabolite of glutamate (show GRIN1 ELISA Kits), restores survival in Slc7a11-overexpressing neoplasm cell lines under glucose starvation.

  4. HIF-1alpha (show HIF1A ELISA Kits) plays a role in cerebral ischaemia-reperfusion -induced glutamate (show GRIN1 ELISA Kits) excitotoxicity via the long-lasting activation of system xc(-) -dependent glutamate (show GRIN1 ELISA Kits) outflow

  5. Results provided important insights into understanding the mechanism associated with xCT deficiency.

  6. Protein expression of xCT was observed throughout the forebrain and amygdala.

  7. Cerebellar astroglia isolated from Atm (show ATM ELISA Kits) mutant mice show decreased expression of the cystine/glutamate (show GRIN1 ELISA Kits) exchanger subunit xCT, glutathione reductase (show GSR ELISA Kits), and glutathione-S-transferase (show GSTa2 ELISA Kits)

  8. IL-1beta (show IL1B ELISA Kits) increases the level of mRNA encoding xCT in primary cultures of astrocytes isolated from mouse cortex.

  9. Study found that aglycemic neuronal cell death does not result from changes in astrocyte system xc- expression or activity or from impairment of glutamate (show GRIN1 ELISA Kits) removal

  10. This study indicated that, under physiological conditions, nonvesicular glutamate (show GRIN1 ELISA Kits) release via system xc- mediates aspects of higher brain function related to anxiety and depression, but does not influence sensorimotor function or spatial vision

SLC7A11 Antigen Profile

Antigen Summary

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Gene names and symbols associated with SLC7A11

  • solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 (SLC7A11) antibody
  • solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 (SLC7A11) antibody
  • solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 (Slc7a11) antibody
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (Slc7a11) antibody
  • 9930009M05Rik antibody
  • AI451155 antibody
  • CCBR1 antibody
  • DKFZp468E122 antibody
  • SLC7A11 antibody
  • sut antibody
  • xCT antibody

Protein level used designations for SLC7A11

solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 , cystine/glutamate transporter , solute carrier family 7, member 11 , Cystine/glutamate transporter , cystine/glutamate transporter-like , solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 , amino acid transport system xc- , calcium channel blocker resistance protein CCBR1 , solute carrier family 7 member 11 , solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 , cysteine/glutamate transporter , sodium independent anionic amino acid transport system

GENE ID SPECIES
428731 Gallus gallus
471310 Pan troglodytes
524078 Bos taurus
696516 Macaca mulatta
100027770 Monodelphis domestica
100049683 Sus scrofa
100091177 Ornithorhynchus anatinus
100172659 Pongo abelii
100386974 Callithrix jacchus
100581045 Nomascus leucogenys
23657 Homo sapiens
310392 Rattus norvegicus
483821 Canis lupus familiaris
26570 Mus musculus
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