Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) ELISA Kits

SLC7A11 encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. Additionally we are shipping SLC7A11 Antibodies (101) and SLC7A11 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SLC7A11 23657 Q9UPY5
SLC7A11 310392  
SLC7A11 26570 Q9WTR6
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Top SLC7A11 ELISA Kits at antibodies-online.com

Showing 5 out of 14 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Rat 0.55 1.56 ng/mL - 100 ng/mL 96 Tests Log in to see 13 to 16 Days
$640.00
Details
Human 4.68 pg/mL 18.75-1200 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details
Mouse 0.156-10 ng/mL   96 Tests Log in to see 2 to 3 Days
$867.90
Details
Human 0.059 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 8 to 12 Days
$766.25
Details
Rat 0.55 1.56   96 Tests Log in to see 8 to 12 Days
$829.25
Details

More ELISA Kits for SLC7A11 Interaction Partners

Human Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) interaction partners

  1. Authors found that the xCT expression was increased in peripheral blood monocyte of active tuberculosis. xCT expression in macrophage was induced by Mycobacterium tuberculosis (Mtb (show NCAPG2 ELISA Kits)) through TLR2 (show TLR2 ELISA Kits)/Akt (show AKT1 ELISA Kits)- and p38 (show CRK ELISA Kits)-dependent signaling pathway.

  2. Genetic and pharmacological inhibition of xCT potentiated the cytotoxic effects of aspirin plus sorafenib; this effect was diminished by xCT overexpression. Low-dose aspirin plus sorafenib enhanced the cytotoxicity of cisplatin in resistant HNC (show MMP8 ELISA Kits) cells through xCT inhibition and oxidant and DNA damage.

  3. MUC1 (show MUC1 ELISA Kits)-C binds directly with CD44v and in turn promotes stability of xCT in the cell membrane

  4. simultaneous mutations at all four acetylation sites completely abolish its ability to regulate metabolic targets, such as TIGAR (show C12orf5 ELISA Kits) and SLC7A11. Moreover, p53 (show TP53 ELISA Kits)(4KR) is still capable of inducing the p53 (show TP53 ELISA Kits)-Mdm2 (show MDM2 ELISA Kits) feedback loop, but p53 (show TP53 ELISA Kits)-dependent ferroptotic responses are markedly abrogated

  5. ARF inhibits tumor growth by suppressing the ability of NRF2 (show GABPA ELISA Kits) to transcriptionally activate its target genes, including SLC7A11, a component of the cystine/glutamate (show GRIN1 ELISA Kits) antiporter that regulates reactive oxygen species (ROS (show ROS1 ELISA Kits))-induced ferroptosis.

  6. Mechanistically, CD44v interacts with and stabilizes xCT and thereby promotes the uptake of cysteine for glutathione synthesis and stimulates side-population cell enrichment.

  7. ATF4 (show ATF4 ELISA Kits) expression fosters the malignancy of primary brain tumors and increases proliferation and tumor angiogenesis; experiments revealed that ATF4 (show ATF4 ELISA Kits)-dependent tumor promoting effects are mediated by transcriptional targeting the glutamate (show GRIN1 ELISA Kits) antiporter xCT

  8. Identify mTORC2 (show CRTC2 ELISA Kits) as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate (show GRIN1 ELISA Kits) antiporter xCT. mTORC2 (show CRTC2 ELISA Kits) phosphorylates serine 26 at the cytosolic N terminus of xCT, inhibiting its activity.

  9. Data suggest that glucose starvation of various neoplasm cell lines induces SLC7A11 expression; SLC7A11 overexpression decreases intracellular glutamate (show GRIN1 ELISA Kits), an alternative source of metabolic energy; provision of alpha-ketoglutarate, a key downstream metabolite of glutamate (show GRIN1 ELISA Kits), restores survival in SLC7A11-overexpressing neoplasm cell lines under glucose starvation.

  10. Results suggest that expression of SLC7A11 in the context of glioma contributes to tumorigenesis, tumor progression, and resistance to standard chemotherapy.

Mouse (Murine) Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) interaction partners

  1. Authors found that the xCT expression was increased in peripheral blood monocyte of active tuberculosis. xCT expression in macrophage was induced by Mycobacterium tuberculosis (Mtb (show NCAPG2 ELISA Kits)) through TLR2 (show TLR2 ELISA Kits)/Akt (show AKT1 ELISA Kits)- and p38 (show CRK ELISA Kits)-dependent signaling pathway.

  2. Protein expression of xCT is enhanced in immune cells from an animal model of multiple sclerosis.

  3. Study suggests that mature astrocytes have low expression levels of xCT and that they do not depend on its function to survive. In contrast, oligodendrocytes, which express high levels of xCT, are the most vulnerable cell type of CNS to glutathione depletion upon chronic blockage of xCT or under oxidative glutamate (show GRIN1 ELISA Kits) toxicity.

  4. ARF inhibits tumor growth by suppressing the ability of NRF2 (show NFE2L2 ELISA Kits) to transcriptionally activate its target genes, including SLC7A11, a component of the cystine/glutamate (show GRIN1 ELISA Kits) antiporter that regulates reactive oxygen species (ROS (show ROS1 ELISA Kits))-induced ferroptosis.

  5. Expression of xCT is reduced in astroglia in a genetic mouse model of susceptibility to depressive-like behavior.

  6. Data suggest that glucose starvation of various neoplasm cell lines induces Slc7a11 expression; Slc7a11 overexpression decreases intracellular glutamate (show GRIN1 ELISA Kits), an alternative source of metabolic energy; provision of alpha-ketoglutarate, a key downstream metabolite of glutamate (show GRIN1 ELISA Kits), restores survival in Slc7a11-overexpressing neoplasm cell lines under glucose starvation.

  7. HIF-1alpha (show HIF1A ELISA Kits) plays a role in cerebral ischaemia-reperfusion -induced glutamate (show GRIN1 ELISA Kits) excitotoxicity via the long-lasting activation of system xc(-) -dependent glutamate (show GRIN1 ELISA Kits) outflow

  8. Results provided important insights into understanding the mechanism associated with xCT deficiency.

  9. Protein expression of xCT was observed throughout the forebrain and amygdala.

  10. Cerebellar astroglia isolated from Atm (show ATM ELISA Kits) mutant mice show decreased expression of the cystine/glutamate (show GRIN1 ELISA Kits) exchanger subunit xCT, glutathione reductase (show GSR ELISA Kits), and glutathione-S-transferase (show GSTa2 ELISA Kits)

SLC7A11 Antigen Profile

Antigen Summary

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Gene names and symbols associated with SLC7A11

  • solute carrier family 7 member 11 (SLC7A11) antibody
  • solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 (SLC7A11) antibody
  • solute carrier family 7 member 11 (Slc7a11) antibody
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (Slc7a11) antibody
  • 9930009M05Rik antibody
  • AI451155 antibody
  • CCBR1 antibody
  • DKFZp468E122 antibody
  • SLC7A11 antibody
  • sut antibody
  • xCT antibody

Protein level used designations for SLC7A11

solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 , cystine/glutamate transporter , solute carrier family 7, member 11 , Cystine/glutamate transporter , cystine/glutamate transporter-like , solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 , amino acid transport system xc- , calcium channel blocker resistance protein CCBR1 , solute carrier family 7 member 11 , solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 , cysteine/glutamate transporter , sodium independent anionic amino acid transport system

GENE ID SPECIES
428731 Gallus gallus
471310 Pan troglodytes
524078 Bos taurus
696516 Macaca mulatta
100027770 Monodelphis domestica
100049683 Sus scrofa
100091177 Ornithorhynchus anatinus
100172659 Pongo abelii
100386974 Callithrix jacchus
100581045 Nomascus leucogenys
23657 Homo sapiens
310392 Rattus norvegicus
483821 Canis lupus familiaris
26570 Mus musculus
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