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Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Additionally we are shipping SLC7A5 Kits (3) and and many more products for this protein.
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Human Polyclonal SLC7A5 Primary Antibody for ELISA, WB - ABIN185255
Finco, Kadlecek, Zhang, Samelson, Weiss: LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. in Immunity 1998
Proliferation of breast cancer cells is dependent on the expression of both LAT1 (show LAT Antibodies) and AHR (show AHR Antibodies).
CD98 (show SLC3A2 Antibodies) promotes cell spreading and tumorigenicity by triggering integrin clustering and enhancing cell adhesion to the extracellular matrix.
Propose regulation of placental SNAT2 (show SLC38A2 Antibodies)/LAT1 (show LAT Antibodies) ubiquitination by mTORC1 and Nedd4-2 (show NEDD4L Antibodies).
Independently of Gleason score, aberrant overexpression of LAT1 (show LAT Antibodies) in prostatic adenocarcinoma could predict LP under EM. Although prostate biopsy samples are small, LAT1 (show LAT Antibodies) may be a novel prognostic biomarker of LP.
LAT1 (show LAT Antibodies) is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter (show SLC43A2 Antibodies).
LAT1 (show LAT Antibodies) can serve as a significant prognostic factor to predict a poor outcome and it may therefore play an important role in the aggressiveness of cutaneous melanoma.
exposure to diesel exhaust particle extract induces functional overexpression of the amino acid transporter (show SLC43A2 Antibodies) LAT1 (show LAT Antibodies)/CD98hc (show SLC3A2 Antibodies) in lung cells
LAPTM4b recruits LAT1 (show LAT Antibodies)-4F2hc (show SLC3A2 Antibodies) to lysosomes, leading to uptake of leucine into lysosomes.
These results suggest that LAT1 (show LAT Antibodies) expression is associated with disease progression in gastric carcinoma.
LAT1 (show LAT Antibodies) and LAT2 (show LAT2 Antibodies) are present and functional in the syncytiotrophoblast MVM, whereas LAT2 (show LAT2 Antibodies) is also expressed in the BM and in the fetal capillary endothelium.
Results demonstrate that lipopolysaccharide-induced inflammation decreases LAT1 mRNA expression at the blood-brain barrier in a very similar manner to primary thyroid hormone (show PTH Antibodies) transporters, while changes in LAT1 protein level follow a slower kinetics.
HIF-2alpha (show EPAS1 Antibodies)/mTORC1/SLC7A5 pathway mediates proliferation and tumor promoting properties of HIF-2alpha (show EPAS1 Antibodies).
expression of candidate thyroid hormone (show PTH Antibodies) transporters Lat1, Mct8 (show MCT8 Antibodies), Mct10 (show SLC16A10 Antibodies), and Oatp1c1 (show SLCO1C1 Antibodies) in mouse cochlear development
These results demonstrate that LAT-1 plays an important role in trophoblast invasion.
TA1 therefore appears to play a modulatory role in catecholaminergic function
Expression studies of LAT-1 in developing mouse placenta show highest levels of LAT-1 mRNA in trophoblast giant cells at the time of implantation, followed by maternal decidua, ectoplacental cone and epiblast.
Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
, L amino acid transporter-1
, solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 a
, large neutral amino acids transporter small subunit 1-like
, L-type amino acid transporter 1
, 4F2 LC
, 4F2 light chain
, CD98 light chain
, integral membrane protein E16
, large neutral amino acids transporter 1
, large neutral amino acids transporter small subunit 1
, sodium-independent neutral amino acid transporter LAT1
, solute carrier family 7 member 5
, y+ system cationic amino acid transporter
, tumor-associated protein 1
, LAT1 light chain
, blood-brain barrier large neutral amino acid transporter light chain