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Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Additionally we are shipping SLC7A5 Kits (4) and and many more products for this protein.
Showing 10 out of 85 products:
Human Polyclonal SLC7A5 Primary Antibody for IF (p), IHC (p) - ABIN1387470
Beals, Sukiennik, Nallabelli, Emmons, van Vliet, Young, Ulanov, Li, Paluska, De Lisio, Burd: Anabolic sensitivity of postprandial muscle protein synthesis to the ingestion of a protein-dense food is reduced in overweight and obese young adults. in The American journal of clinical nutrition 2016
Show all 2 references for 1387470
Human Polyclonal SLC7A5 Primary Antibody for ELISA, WB - ABIN4354499
Ohno, Suda, Masuko, Yagi, Hashimoto, Masuko: Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human L-type amino-acid transporter 1. in Cancer science 2008
Human Polyclonal SLC7A5 Primary Antibody for ELISA, WB - ABIN185255
Finco, Kadlecek, Zhang, Samelson, Weiss: LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. in Immunity 1998
Human Polyclonal SLC7A5 Primary Antibody for IHC (p), IHC - ABIN152153
Padbury, Diah, McGonnigal, Miller, Fugere, Kuzniar, Thompson: Transcriptional regulation of the LAT-1/CD98 light chain. in Biochemical and biophysical research communications 2004
MTA1 (show MTA1 Antibodies) expression was positively correlated with LAT1 (show LAT Antibodies) (p=0.013) and CD34 (show CD34 Antibodies) (p=0.034) expression, but not with Ki-67 (show MKI67 Antibodies) (p=0.078). MTA1 (show MTA1 Antibodies) shows promise as a diagnostic and prognostic marker in esophageal cancer, and we anticipate that the gene will also prove to be a good therapeutic target.
LAT1 (show LAT Antibodies) overexpression was common in Brain Metastases and was specific for Brain Metastases as compared to healthy brain. These results could explain the specific Brain Metastases uptake on PET-AA.
LAT1 (show LAT Antibodies) and LAT2 (show LAT2 Antibodies) were overexpressed in both pheochromocytoma and medullary thyroid carcinoma by comparison with normal tissues.
he findings in this study indicate a regulation relationship between CRKL (show CRKL Antibodies) and SLC7A5, and provide useful evidence for gastric cancer therapeutic strategies.
Study shows that the solute carrier (show SERTAD2 Antibodies) transporter 7a5 (show MACC1 Antibodies) (SLC7A5), a large neutral amino acid transporter (show SLC6A19 Antibodies) localized at the blood brain barrier (BBB (show ALMS1 Antibodies)), has an essential role in maintaining normal levels of brain branched-chain amino acids; also identified several patients with autistic traits and motor delay carrying deleterious homozygous mutations in the SLC7A5 gene.
The LAT1 (show LAT Antibodies) isoform was confirmed as the major tyrosine transporter in patients with schizophrenia. However, the kinetic parameters (maximal transport capacity, affinity of the binding sites, and diffusion constant of tyrosine transport through the LAT1 (show LAT Antibodies) isoform) did not differ between patients with schizophrenia and controls.
Expression levels of CD98 (show SLC3A2 Antibodies) and beta1-integrin-A (the activated form of beta1-integrin) were significantly increased in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) tissues relative to those of normal liver tissues.
Authors demonstrate that LAT1 (show LAT Antibodies) is a critical transporter for human thymic carcinoma cells. LAT1 (show LAT Antibodies) was strongly expressed in human thymic carcinoma tissues.
Our study demonstrates that suppression of l-type amino acid transporter-1 activity using JPH203 might be used as a new therapeutic strategy for cholangiocarcinoma treatment.
This study shows the utility of (18)F-FBPA as a tumor-specific probe of LAT1 (show LAT Antibodies) with low accumulation in the inflammatory lesions.
results revealed that L-type amino acid transporter 1 solute carrier family 7 member 5(lat1) might play an important role in the decidual progression both in vitro and in vivo in the mouse
Results demonstrate that lipopolysaccharide-induced inflammation decreases LAT1 mRNA expression at the blood-brain barrier in a very similar manner to primary thyroid hormone (show PTH Antibodies) transporters, while changes in LAT1 protein level follow a slower kinetics.
HIF-2alpha (show EPAS1 Antibodies)/mTORC1/SLC7A5 pathway mediates proliferation and tumor promoting properties of HIF-2alpha (show EPAS1 Antibodies).
expression of candidate thyroid hormone (show PTH Antibodies) transporters Lat1, Mct8 (show MCT8 Antibodies), Mct10 (show SLC16A10 Antibodies), and Oatp1c1 (show SLCO1C1 Antibodies) in mouse cochlear development
These results demonstrate that LAT-1 plays an important role in trophoblast invasion.
TA1 therefore appears to play a modulatory role in catecholaminergic function
Expression studies of LAT-1 in developing mouse placenta show highest levels of LAT-1 mRNA in trophoblast giant cells at the time of implantation, followed by maternal decidua, ectoplacental cone and epiblast.
Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
, L amino acid transporter-1
, solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 a
, large neutral amino acids transporter small subunit 1-like
, L-type amino acid transporter 1
, 4F2 LC
, 4F2 light chain
, CD98 light chain
, integral membrane protein E16
, large neutral amino acids transporter 1
, large neutral amino acids transporter small subunit 1
, sodium-independent neutral amino acid transporter LAT1
, solute carrier family 7 member 5
, y+ system cationic amino acid transporter
, tumor-associated protein 1
, LAT1 light chain
, blood-brain barrier large neutral amino acid transporter light chain