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anti-Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) Antibodies

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. Additionally we are shipping SLC8A1 Kits (16) and SLC8A1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC8A1 6546 P32418
SLC8A1 29715 Q01728
SLC8A1 20541 P70414
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Top anti-SLC8A1 Antibodies at

Showing 10 out of 48 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of SLC8A1 Antibody (Center) (ABIN652886) in HL-60, K562 cell line lysates (35 µg/lane). SLC8A1 (arrow) was detected using the purified polyclonal antibody. SLC8A1 Antibody (Center) (ABIN652886) IHC analysis in formalin fixed and paraffin embedded mouse brain followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 14 Days
Cow Rabbit Un-conjugated WB Western blot analysis of NCX1 expression in K562 (A), A549 (B), HL60 (C) whole cell lysates. 200 μL Log in to see 9 Days
Mammalian Mouse Un-conjugated WB 100 μg Log in to see 6 to 11 Days
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using SLC8A1 antibody. 100 μL Log in to see 14 Days
Human Mouse Un-conjugated ELISA, WB   0.1 mL Log in to see 2 to 6 Days
Cow Mouse Un-conjugated WB Western blot of various tissues showing specific immunolabeling of the 120 kDa and 20 kDa NaCX-1 protein. Lane 1 - Brain, Lane 2 - Heart, Lane 3 - Kidney, Lane 4 - Lung, Lane 5 - Spleen. Dilution: 1:1000 100 μg Log in to see 10 to 11 Days
Human Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days
Rat Rabbit Un-conjugated ELISA, WB   50 μg Log in to see 8 to 10 Days

SLC8A1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
, , , , ,
Rat (Rattus)
Mouse (Murine)

More Antibodies against SLC8A1 Interaction Partners

Human Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) interaction partners

  1. Palmitoylation of cardiac NCX1 can modify its function, physical interactions, and removal from the sarcolemma by domain-dependent endocytosis.

  2. NCX1 and the calcium binding protein (show CETN1 Antibodies) calretinin (show CALB2 Antibodies) cooperate within the striatum to confer tolerance against cerebral ischemia.

  3. ADD2 (show ADD2 Antibodies) and NCX1 variants influence the risk and the clinical features of systemic lupus erythematosus and lupus nephritis.

  4. NCX1 operating in reverse mode plays a prominent role in calcium cytosolic regulation in highly metastatic melanoma cells.

  5. The expression of miR (show MLXIP Antibodies)-206 by HUVECs reduced exosome production by regulating ADP-Ribosylation Factor 6 (ARF6 (show ARF6 Antibodies)) and sodium/calcium exchanger 1 (NCX1).

  6. interaction of NHE1 (show SLC9A1 Antibodies), NCX1 and CaM (show CALM1 Antibodies) mediates the effects of IL6 (show IL6 Antibodies) on human hepatocellular carcinoma

  7. NCX1.3 is the predominant NCX (show TLX2 Antibodies) variant in the distal convoluted and connecting tubules tubules

  8. results demonstrate that CaM (show CALM1 Antibodies) senses changes in [Ca2 (show CA2 Antibodies)+]i and binds to the cytoplasmic loop of NCX1 to regulate exchange activity.

  9. The expressions of NCX1 and NCKX4 (show Slc24a4 Antibodies) were significantly higher in the patent ductus arteriosus group at both the protein and mRNA levels.

  10. Down-regulation of the SLC8A1 gene, most likely mediated by its regulator miR (show MLXIP Antibodies)-223, can lead to decreased calcium in penile carcinoma and consequently to suppressed apoptosis and increased tumor cell proliferation

Rabbit Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) interaction partners

  1. The SOCE/Cl(Ca) interaction does not require reverse-mode Na+/Ca2 (show CA2 Antibodies)+ exchange in our conditions.

  2. There were substantial transmural gradients in Cav1.2 (show CACNA1C Antibodies), KChIP2 (show KCNIP2 Antibodies), ERG (show KCNH2 Antibodies), KvLQT1 (show KCNQ1 Antibodies), Kir2.1 (show KCNJ2 Antibodies), NCX1, SERCA2a (show ATP2A2 Antibodies) and RyR2 (show RYR2 Antibodies) at the mRNA and, in some cases, protein level-in every case the mRNA or protein was more abundant in the epicardium than the endocardium.

Guinea Pig Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) interaction partners

  1. NCX is an important determinant for premature ventricular activity in a drug-induced model of Andersen-Tawil syndrome.

Mouse (Murine) Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) interaction partners

  1. NCX1 and NCX2 (show SLC8A2 Antibodies) play important roles in ileal motility and suggest that NCX1 and NCX2 (show SLC8A2 Antibodies) regulate the motility in the ileum by controlling the sensitivity of smooth muscles to ACh (show FGFR3 Antibodies) and SP.

  2. Data show that transforming growth factor beta1 (TGFbeta1 (show TGFB1 Antibodies)) is a powerful stimulator of both, store operated Ca2 (show CA2 Antibodies)+ entry (SOCE) and Na+/Ca2+-exchanger activity in megakaryocytes.

  3. dobutamine upregulates of voltage-gated Na+ channel function and Na+ influx-induced activation of the reverse mode of NCX

  4. JAK3 (show JAK3 Antibodies) deficiency is followed by down-regulation of cytosolic Ca(2 (show CA2 Antibodies)+) release, receptor and store operated Ca(2 (show CA2 Antibodies)+) entry and Na(+)/Ca(2 (show CA2 Antibodies)+) exchanger activity in dendritic cells.

  5. Results suggested that down-regulation of hippocampal NCX1 expression is associated with pentylenetetrazole-induced kindling seizure development

  6. TRPC3 (show TRPC3 Antibodies)-NCX micro/nanodomain communication as determinant of cardiac contractility and susceptibility to arrhythmogenic stimuli.

  7. cellular Ca accumulation hinders spontaneous depolarization in the NCX knockout sinoatrial node, possibly by inhibiting L-type Ca currents.

  8. thrombin (show F2 Antibodies)-induced ERK1/2 (show MAPK1/3 Antibodies) activation required NADPH oxidase 2 (show CYBB Antibodies)-mediated reactive oxygen species (ROS (show ROS1 Antibodies)) production, and reverse-mode NCX inhibitors and NCX1 siRNA suppressed thrombin (show F2 Antibodies)-induced ROS (show ROS1 Antibodies) production

  9. NCX1 plays an important role in smooth muscle motility in the mouse distal colon.

  10. There is a functional role of sodium-calcium exchanger SLC8A1 in human atrial and atrioventricular nodal conduction as suggested by genetically modified mouse models.

Cow (Bovine) Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) interaction partners

  1. These results indicate that, for a proper MgATP up-regulation of NCX1, the enzyme responsible for PtdIns-4,5P2 synthesis must be (i) functionally competent and (ii) set in the NCX1 microenvironment closely associated to the exchanger.

  2. The cleavage of NCX1 by m-calpain (show CAPN2 Antibodies) in the caveolae vesicles may be interpreted as an important mechanism of Ca(2 (show CA2 Antibodies)+) overload

  3. a novel mechanism for the regulation of NCX1 activity

  4. Na/Ca exchanger's (NCX1) associates specifically with caveolin-3 (show CAV3 Antibodies)(NCX1)(caveolin-3 (show CAV3 Antibodies))

  5. the regulation of phosphatidylinositol-4,5-biphosphate binding to the bovine cardiac Na+/Ca2+ exchanger(NCX1)

  6. Data suggest that peroxynitrite leads to calcium (Ca2 (show CA2 Antibodies)+) uptake through stimulation of Ca2+-ATPase, but inhibits Ca2 (show CA2 Antibodies)+ uptake through inhibition of the sodium-Ca2 (show CA2 Antibodies)+ exchanger, resulting in decreased overall Ca2 (show CA2 Antibodies)+ uptake in smooth muscle microsomes.

  7. These data suggest a role for the reverse mode of the NCX in refilling the sarcoplasmic reticulum in airway smooth muscle following Ca(2 (show CA2 Antibodies)+) mobilization.

  8. Cleavage of NCX may be interpreted as the main cause of Ca(2 (show CA2 Antibodies)+) overload and could lay a key role in activation of apoptotic processes in pulmonary smooth muscle.

SLC8A1 Antigen Profile

Protein Summary

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.

Gene names and symbols associated with SLC8A1

  • solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1) antibody
  • solute carrier family 8 (sodium/calcium exchanger), member 1b (slc8a1b) antibody
  • sodium/calcium exchanger 1 (Tsp_07038) antibody
  • solute carrier family 8 (sodium/calcium exchanger), member 1 (Slc8a1) antibody
  • T cell leukemia, homeobox 2 (Tlx2) antibody
  • AI852629 antibody
  • AV344025 antibody
  • D930008O12Rik antibody
  • Enx antibody
  • Hox11L.1 antibody
  • Hox11l1 antibody
  • NCX antibody
  • Ncx1 antibody
  • ncx1n antibody
  • SLC8A1 antibody
  • Tlx1l1 antibody
  • Tlx1l2 antibody

Protein level used designations for SLC8A1

solute carrier family 8 (sodium/calcium exchanger), member 1 , sodium/calcium exchanger 1 , ncx1b , sodium calcium exchanger 1n , sodium/calcium exchanger 1-like , Na(+)/Ca(2+)-exchange protein 1 , Na+/Ca++ exchanger , Na+/Ca2+ exchanger , sodium/calcium exchanger , solute carrier family 8 member 1 , Na/Ca exchanger , Na-Ca exchanger , solute carrier family 8, member 1 , sodium-calcium exchanger , sodium/calcium exchanger isoform NaCa13 , sodium/calcium exchanger isoform NaCa3 , sodium/calcium exchanger isoform NaCa9 , sodium/calcium exchanger isoform NaCa7 , PMUR10F , T-cell leukemia homeobox protein 2 , T-cell leukemia, homeobox 2 , enteric neuron homeobox protein , homeo box 11-like 1 , homeobox TLX-2 , homeobox protein Hox-11L1

470358 Pan troglodytes
797199 Danio rerio
10903331 Trichinella spiralis
100074200 Ornithorhynchus anatinus
100172867 Pongo abelii
100412198 Callithrix jacchus
6546 Homo sapiens
493808 Canis lupus familiaris
100328570 Oryctolagus cuniculus
29715 Rattus norvegicus
100135620 Cavia porcellus
20541 Mus musculus
395760 Gallus gallus
337925 Bos taurus
493807 Felis catus
475738 Canis lupus familiaris
21909 Mus musculus
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