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Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 Proteins (SLC8A1)

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. Additionally we are shipping SLC8A1 Antibodies (46) and SLC8A1 Kits (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC8A1 6546 P32418
Rat SLC8A1 SLC8A1 29715 Q01728
SLC8A1 20541 P70414
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Top SLC8A1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details

SLC8A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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More Proteins for Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) Interaction Partners

Human Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) interaction partners

  1. ADD2 (show ADD2 Proteins) and NCX1 variants influence the risk and the clinical features of systemic lupus erythematosus and lupus nephritis.

  2. NCX1 operating in reverse mode plays a prominent role in calcium cytosolic regulation in highly metastatic melanoma cells.

  3. The expression of miR (show MLXIP Proteins)-206 by HUVECs reduced exosome production by regulating ADP-Ribosylation Factor 6 (ARF6 (show ARF6 Proteins)) and sodium/calcium exchanger 1 (NCX1).

  4. interaction of NHE1 (show SLC9A1 Proteins), NCX1 and CaM (show CALM1 Proteins) mediates the effects of IL6 (show IL6 Proteins) on human hepatocellular carcinoma

  5. NCX1.3 is the predominant NCX (show TLX2 Proteins) variant in the distal convoluted and connecting tubules tubules

  6. results demonstrate that CaM (show CALM1 Proteins) senses changes in [Ca2 (show CA2 Proteins)+]i and binds to the cytoplasmic loop of NCX1 to regulate exchange activity.

  7. The expressions of NCX1 and NCKX4 (show Slc24a4 Proteins) were significantly higher in the patent ductus arteriosus group at both the protein and mRNA levels.

  8. Down-regulation of the SLC8A1 gene, most likely mediated by its regulator miR (show MLXIP Proteins)-223, can lead to decreased calcium in penile carcinoma and consequently to suppressed apoptosis and increased tumor cell proliferation

  9. These data confirm the role of NCX1 activity in regulating renal epithelial cell migration.

  10. Three novel loci were identified in East Asians with cardiac arrhythmias: rs2483280 (PRDM16 (show PRDM16 Proteins) locus) and rs335206 (PRDM6 (show PRDM6 Proteins) locus) were associated with QRS (show QARS Proteins) duration; and rs17026156 (SLC8A1 locus) correlated with PR interval.

Rabbit Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) interaction partners

  1. The SOCE/Cl(Ca) interaction does not require reverse-mode Na+/Ca2 (show CA2 Proteins)+ exchange in our conditions.

  2. There were substantial transmural gradients in Cav1.2, KChIP2, ERG, KvLQT1, Kir2.1, NCX1, SERCA2a and RyR2 at the mRNA and, in some cases, protein level-in every case the mRNA or protein was more abundant in the epicardium than the endocardium.

Guinea Pig Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) interaction partners

  1. NCX is an important determinant for premature ventricular activity in a drug-induced model of Andersen-Tawil syndrome.

Mouse (Murine) Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) interaction partners

  1. dobutamine upregulates of voltage-gated Na+ channel function and Na+ influx-induced activation of the reverse mode of NCX

  2. JAK3 (show JAK3 Proteins) deficiency is followed by down-regulation of cytosolic Ca(2 (show CA2 Proteins)+) release, receptor and store operated Ca(2 (show CA2 Proteins)+) entry and Na(+)/Ca(2 (show CA2 Proteins)+) exchanger activity in dendritic cells.

  3. Results suggested that down-regulation of hippocampal NCX1 expression is associated with pentylenetetrazole-induced kindling seizure development

  4. TRPC3 (show TRPC3 Proteins)-NCX micro/nanodomain communication as determinant of cardiac contractility and susceptibility to arrhythmogenic stimuli.

  5. cellular Ca accumulation hinders spontaneous depolarization in the NCX knockout sinoatrial node, possibly by inhibiting L-type Ca currents.

  6. thrombin (show F2 Proteins)-induced ERK1/2 activation required NADPH oxidase 2 (show CYBB Proteins)-mediated reactive oxygen species (ROS (show ROS1 Proteins)) production, and reverse-mode NCX inhibitors and NCX1 siRNA suppressed thrombin (show F2 Proteins)-induced ROS (show ROS1 Proteins) production

  7. NCX1 plays an important role in smooth muscle motility in the mouse distal colon.

  8. There is a functional role of sodium-calcium exchanger SLC8A1 in human atrial and atrioventricular nodal conduction as suggested by genetically modified mouse models.

  9. Negative regulation of NCX1- mediated renal Ca(2 (show CA2 Proteins)+) absorption by IFNgamma may significantly contribute to the altered Ca(2 (show CA2 Proteins)+) homeostasis in IBD patients and to IBD-associated loss of bone mineral density

  10. human osteoblasts and osteoblasts from Ano6 (show ANO6 Proteins)(-/-) and WT mice, we demonstrate that NCX1 requires Ano6 (show ANO6 Proteins) to efficiently translocate Ca(2 (show CA2 Proteins)+) out of osteoblasts into the calcifying bone matrix

Cow (Bovine) Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) interaction partners

  1. These results indicate that, for a proper MgATP up-regulation of NCX1, the enzyme responsible for PtdIns-4,5P2 synthesis must be (i) functionally competent and (ii) set in the NCX1 microenvironment closely associated to the exchanger.

  2. The cleavage of NCX1 by m-calpain (show CAPN2 Proteins) in the caveolae vesicles may be interpreted as an important mechanism of Ca(2 (show CA2 Proteins)+) overload

  3. a novel mechanism for the regulation of NCX1 activity

  4. Na/Ca exchanger's (NCX1) associates specifically with caveolin-3 (show CAV3 Proteins)(NCX1)(caveolin-3 (show CAV3 Proteins))

  5. the regulation of phosphatidylinositol-4,5-biphosphate binding to the bovine cardiac Na+/Ca2+ exchanger(NCX1)

  6. Data suggest that peroxynitrite leads to calcium (Ca2 (show CA2 Proteins)+) uptake through stimulation of Ca2+-ATPase, but inhibits Ca2 (show CA2 Proteins)+ uptake through inhibition of the sodium-Ca2 (show CA2 Proteins)+ exchanger, resulting in decreased overall Ca2 (show CA2 Proteins)+ uptake in smooth muscle microsomes.

  7. These data suggest a role for the reverse mode of the NCX in refilling the sarcoplasmic reticulum in airway smooth muscle following Ca(2 (show CA2 Proteins)+) mobilization.

  8. Cleavage of NCX may be interpreted as the main cause of Ca(2 (show CA2 Proteins)+) overload and could lay a key role in activation of apoptotic processes in pulmonary smooth muscle.

SLC8A1 Protein Profile

Protein Summary

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.

Gene names and symbols associated with SLC8A1

  • solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1)
  • solute carrier family 8 (sodium/calcium exchanger), member 1b (slc8a1b)
  • sodium/calcium exchanger 1 (Tsp_07038)
  • solute carrier family 8 (sodium/calcium exchanger), member 1 (Slc8a1)
  • T cell leukemia, homeobox 2 (Tlx2)
  • AI852629 protein
  • AV344025 protein
  • D930008O12Rik protein
  • Enx protein
  • Hox11L.1 protein
  • Hox11l1 protein
  • NCX protein
  • Ncx1 protein
  • ncx1n protein
  • SLC8A1 protein
  • Tlx1l1 protein
  • Tlx1l2 protein

Protein level used designations for SLC8A1

solute carrier family 8 (sodium/calcium exchanger), member 1 , sodium/calcium exchanger 1 , ncx1b , sodium calcium exchanger 1n , sodium/calcium exchanger 1-like , Na(+)/Ca(2+)-exchange protein 1 , Na+/Ca++ exchanger , Na+/Ca2+ exchanger , sodium/calcium exchanger , solute carrier family 8 member 1 , Na/Ca exchanger , Na-Ca exchanger , solute carrier family 8, member 1 , sodium-calcium exchanger , sodium/calcium exchanger isoform NaCa13 , sodium/calcium exchanger isoform NaCa3 , sodium/calcium exchanger isoform NaCa9 , sodium/calcium exchanger isoform NaCa7 , PMUR10F , T-cell leukemia homeobox protein 2 , T-cell leukemia, homeobox 2 , enteric neuron homeobox protein , homeo box 11-like 1 , homeobox TLX-2 , homeobox protein Hox-11L1

GENE ID SPECIES
470358 Pan troglodytes
797199 Danio rerio
10903331 Trichinella spiralis
100074200 Ornithorhynchus anatinus
100172867 Pongo abelii
100412198 Callithrix jacchus
6546 Homo sapiens
493808 Canis lupus familiaris
100328570 Oryctolagus cuniculus
29715 Rattus norvegicus
100135620 Cavia porcellus
20541 Mus musculus
395760 Gallus gallus
337925 Bos taurus
493807 Felis catus
475738 Canis lupus familiaris
21909 Mus musculus
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