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SLC8A3 encodes a member of the sodium/calcium exchanger integral membrane protein family. Additionally we are shipping Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 3 Antibodies (53) and many more products for this protein.
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In the discovery phase, 60 loci not previously associated with rheumatoid arthritis risk showed evidence for association and were tested for replication in the validation cohort. A total of 12 loci were replicated at the nominal level. When combining the discovery and validation cohorts, an intronic SNP in SLC8A3 was found to be associated with ACPA (show PRTN3 Proteins)-positive rheumatoid arthritis at a genome-wide level of significance.
Ayloid beta mediates calpain cleavage of NCX3 in Alzheimer's disease brain.
NCX1 (show SLC8A1 Proteins) and NCX3 -represent two promising druggable targets for setting on new strategies in stroke therapy.
NCX (show TLX2 Proteins) isoforms (NCX2, NCX3) contribute to mitochondrial Na(+)/Ca(2 (show CA2 Proteins)+) exchange in human DAergic neurons and may act downstream of PINK1 (show PINK1 Proteins) in the prevention of neurodegeneration by m[Ca(2 (show CA2 Proteins)+)] accumulation.
the large cytosolic loop of NCX1 (show SLC8A1 Proteins), NCX2, and NCX3 is involved in acquisition of immunosuppressive drug specificity
Functional studies, as well as mRNA and protein expression analyses, revealed that NCX1 and NCX3, but not NCX2, were divergently modulated during OPC differentiation into oligodendrocyte.
human macrophages and monocytes express NCX1 (show SLC8A1 Proteins) and NCX3 that operate in a bidirectional manner to restore [Ca(2 (show CA2 Proteins)+)](i) to generate Ca(2 (show CA2 Proteins)+) signals and to induce TNF-alpha (show TNF Proteins) production.
calcium signaling mediated by NCX3 has a crucial role in oligodendrocyte maturation and myelin formation.
Human platelets express K(+) -independent Na(+) /Ca(2 (show CA2 Proteins)+) exchangers NCX1.3, NCX3.2 and NCX3.4.
Data suggest that NCX (show TLX2 Proteins)-mediated Ca(2 (show CA2 Proteins)+) fluxes normally exist in human ASM (show SMPD1 Proteins) (potentially contributing to rapid Ca(2 (show CA2 Proteins)+) fluxes), and contribute to enhanced [Ca(2 (show CA2 Proteins)+)](i) regulation in airway inflammation.
Demonstrate that NCX3 genetic deletion protects against ziram-induced neurotoxicity and suggest NCX3 and its downstream molecular pathways as key factors involved in ziram toxicity.
NCX3 regulates mitochondrial calcium handling from the outer mitochondrial membrane through an AKAP121 (show AKAP1 Proteins)-anchored signaling complex.
Function and regulation of the Na+-Ca2+ exchanger (show SLC8A1 Proteins) NCX3 splice variants in brain and skeletal muscle.
the use of genetic-modified mice for NCX1 (show SLC8A1 Proteins), NCX2, and NCX3 represents a fruitful strategy to characterize the physiological role exerted by NCX (show SLC8A1 Proteins) in CNS
the solution structure of NCX3 calcium binding domain 2B
Results show that glucocorticoid treatment blunts LPS (show TLR4 Proteins)-induced increase in [Ca(2 (show CA2 Proteins)+)](i) in dendritic cells by increasing expression and activity of Na(+)/Ca(2 (show CA2 Proteins)+) exchanger NCX3.
The deletion of the NCX3 gene has detrimental consequences on basal synaptic transmission, long term potentiation regulation, spatial learning, and memory performance.
These results showed significant expression of NCX1 (show SLC8A1 Proteins) and NCX3 in ameloblasts, indicating their involvement in the directional Ca(2 (show CA2 Proteins)+) extrusion pathway from cells to the enamel mineralizing front
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described.
solute carrier family 8 (sodium-calcium exchanger), member 3
, solute carrier family 8 member 3
, solute carrier family 8 (sodium/calcium exchanger), member 3
, sodium/calcium exchanger 3-like
, Na(+)/Ca(2+)-exchange protein 3
, Na+/Ca2+ exchanger 3
, sodium/calcium exchanger 3
, sodium/calcium exchanger SLC8A3
, sodium-calcium exchanger