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SLC9A1 encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. Additionally we are shipping Solute Carrier Family 9, Subfamily A (NHE1, Cation Proton Antiporter 1), Member 1 Proteins (6) and Solute Carrier Family 9, Subfamily A (NHE1, Cation Proton Antiporter 1), Member 1 Kits (3) and many more products for this protein.
Showing 10 out of 83 products:
Dog (Canine) Monoclonal SLC9A1 Primary Antibody for IF, WB - ABIN968659
Aharonovitz, Zaun, Balla, York, Orlowski, Grinstein: Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate. in The Journal of cell biology 2000
Show all 5 references for ABIN968659
Human Polyclonal SLC9A1 Primary Antibody for EIA, IHC (p) - ABIN500339
Mendoza: The Na+-H+ antiport is a mediator of cell proliferation. in Acta paediatrica Scandinavica 1987
Show all 2 references for ABIN500339
Human Polyclonal SLC9A1 Primary Antibody for WB - ABIN265248
Pang, Wakabayashi, Shigekawa: Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger. in The Journal of biological chemistry 2002
Show all 2 references for ABIN265248
Human Polyclonal SLC9A1 Primary Antibody for WB - ABIN4620363
Slepkov, Chow, Lemieux, Fliegel: Proline residues in transmembrane segment IV are critical for activity, expression and targeting of the Na+/H+ exchanger isoform 1. in The Biochemical journal 2004
Show all 2 references for ABIN4620363
Mammalian Monoclonal SLC9A1 Primary Antibody for WB - ABIN180918
Rutherford, Pizzonia, Biemesderfer, Abu-Alfa, Reilly, Aronson: Expression of Na(+)-H+ exchanger isoforms NHE1 and NHE3 in kidney and blood cells of rabbit and rat. in Experimental nephrology 1998
Arabidopsis thaliana Polyclonal SLC9A1 Primary Antibody for ELISA, WB - ABIN3197494
Chen, Xiao, Wu, Dong, He, Pei, Zheng: Nitric oxide enhances salt secretion and Na(+) sequestration in a mangrove plant, Avicennia marina, through increasing the expression of H(+)-ATPase and Na(+)/H(+) antiporter under high salinity. in Tree physiology 2010
Tonoplast-localized NHX1 and NHX2 proteins are essential for active K+ uptake at the tonoplast, for turgor regulation, and for stomatal function.
Overexpression of AtNHX1 gene not only improved salt tolerance but also drought tolerance in transgenic groundnut.
NHX1 and NHX2 mediate K+/H+ exchange to accumulate K+ in the vacuole. NHX1 and NHX2 function together to control cell expansion in vegetative tissues and male reproductive organs and are required for normal flower development.
Studies shoe that the rutin content of the roots, stems and leaves of AtNHX1 transgenic buckwheat increased than those of the control plants.
Use of the T-DNA insertional mutant of AtNHX1 (nhx1 plants) and DNA arrays to assess differences in transcriptional profiles and further characterize the roles of this protein.
the presence of a vacuolar calmodulin-like (show KRIT1 Antibodies) protein acting on the vacuolar-localized AtNHX1 C terminus in a Ca(2 (show CA2 Antibodies)+)- pH-dependent manner suggests the presence of signaling entities acting within the vacuole.
AtNHX1 has a role in calcium signaling, sulfur metabolism, cell structure and cell growth, as well as vesicular trafficking and protein processing.
To generate salt-tolerant turf and forage, tall fescue (Festuca arundinacea) was transformed with AtNHX1.
During hypoxia, activation of ROCK enhances NHE1 activity and promotes pulmonary artery smooth muscle cell migration and proliferation.
Na/H exchanger is regulated in dendritic cells by Akt1 (show AKT1 Antibodies).
our results suggest that activation of NHE1 induces hypertrophy through the activation of NFAT3 (show NFATC4 Antibodies)/Gata4 (show GATA4 Antibodies) and OPN (show SPP1 Antibodies) expression
NHE1 function is necessary for maintaining mammary branched architecture.
the extracellular matrix (ECM (show MMRN1 Antibodies)) composition strongly impacts on NHE1-dependent in vitro cell motility and invasion
long-term ablation of NHE1 activity increases the redox potential, mitigates high-fat diet-induced myocardial stress.
study shows that NHE-1 protein is abundantly expressed in microglial lamellipodia and maintains alkaline pHi in response to BK stimulation
exerts a protective effect by reducing the loss of synaptopodin (show SYNPO Antibodies) in podocytes exposed to endoplasmic reticulum stress
NHE1 functions as a metabolic sensor for lipotoxicity.
PDGFRalpha signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1 (show MAP2K1 Antibodies)/2-ERK1/2 (show MAPK1/3 Antibodies)-p90RSK (show RPS6KA1 Antibodies) and AKT (show AKT1 Antibodies) signaling pathways.
This study evaluated the role for NHE-1 in diabetic cataract formation and retinal oxidative stress and apoptosis.
Results support the hypothesis that a blood-brain barrier Na/H exchanger, possibly NHE1 and/or NHE2 (show SLC9A2 Antibodies), is stimulated during ischemia to participate in cerebral edema formation.
NHE isoform switching and KChIP2 (show KCNIP2 Antibodies) upregulation takes place in aging porcine atria.
NHE-1 inhibitor cariporide attenuates skeletal muscle infarction when administered before ischemia or reperfusion.
In human ovarian cancer cells the inducible nitric oxide synthase (iNOS (show NOS2 Antibodies)) is overexpressed leading to increased formation of nitric oxide (NO). The NO promotes a glycolytic phenotype (Warburg effect) leading to H+ generation, which are removed via the sodium, proton (H+) exchanger isoform 1 (NHE1) reducing the intracellular content of this acid equivalent.
Data show that both mineralcorticoid receptor (MR) and G-protein estrogen receptor (show ESR1 Antibodies) (GPER (show GPER Antibodies)) contribute to the proliferation and migration of breast and endothelial cancer cells by sodium-hydrogen exchanger 1 protein (NHE-1) upon aldosterone exposure.
Human NHE1 acts as an ERK2 (show MAPK1 Antibodies) membrane protein scaffold in vivo that is necessary for ERK2 (show MAPK1 Antibodies) activation via direct interactions, and loss of scaffolding by NHE1 leads to decreased ERK2 (show MAPK1 Antibodies) activation.
interaction of NHE1, NCX1 (show SLC8A1 Antibodies) and CaM (show CALM1 Antibodies) mediates the effects of IL6 (show IL6 Antibodies) on human hepatocellular carcinoma
the present study revealed that miR (show MLXIP Antibodies)-27b is upregulated by HPV16 E7 to inhibit PPARg (show PPARG Antibodies) expression and promotes proliferation and invasion in cervical carcinoma cells.
The NHE-1 is a ubiquitously expressed cell membrane protein which regulates intracellular pH (pH(i)) and extracellular pH (pH(e)) homeostasis and cell volume.
Functional studies of N266H mutation in SLC9A1 gene showed a minor effect on the level of expression and no effect on targeting of the protein, however there was a complete absence of SLC9A1 activity.
PKC-delta (show PKCd Antibodies) activates p38/MAPK (show MAPK14 Antibodies), responsible for the inhibition of MMP-2 (show MMP2 Antibodies) and -9 secretion, PKC-epsilon (show PRKCE Antibodies) activates a pathway made of ERK1/2 (show MAPK1/3 Antibodies), mTOR (show FRAP1 Antibodies) and S6K (show RPS6KB1 Antibodies) responsible for the inhibition of NHE1 activity and cell migration.
Data suggest that Na/H exchanger isoform one (NHE1) is critical in triple-negative breast cancer metastasis.
Importantly, the specific NHE1 inhibitor cariporide reduced both three-dimensional growth and invasion independently of PDAC subtype and synergistically sensitized these behaviors to low doses of erlotinib.
In vitro phosphorylation of NHE1 C-terminal fusion proteins determined that ERK (show MAPK1 Antibodies)-dependent phosphorylation of the cytoplasmic region was not dependent on Ser (show SIGLEC1 Antibodies)(703); however, phosphorylation by p90(rsk (show RPS6KA1 Antibodies)) required Ser (show SIGLEC1 Antibodies)(703).
This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth.
, Na(+)/H(+) exchanger 1
, Na+/H+ antiporter
, Na+/H+, amiloride sensitive
, slow-wave epilepsy
, sodium/hydrogen exchanger 1
, solute carrier family 9 member 1
, solute carrier family 9, member 1
, sodium proton exchanger
, solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive)
, solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive)
, Solute carrier family 9 member 1
, NA(+)-H+ exchanger protein
, Na-Li countertransporter
, Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive)
, solute carrier family 9 (sodium/hydrogen exchanger), member 1
, Na+/H+ exchanger
, pH regulatory protein (Na(+) /H(+) exchanger)