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Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 Proteins (SLC9A3R2)

SLC9A3R2 encodes a member of the NHERF family of PDZ scaffolding proteins. Additionally we are shipping Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 Antibodies (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC9A3R2 65962 Q9JHL1
SLC9A3R2 9351 Q15599
SLC9A3R2 116501 Q920G2
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Top Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$750.20
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,847.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,911.33
Details

SLC9A3R2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human
,
Rat (Rattus)

More Proteins for Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Interaction Partners

Zebrafish Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) interaction partners

  1. Results strongly support an important role for NHERF1 in the regulation of Planar Cell Polarity signaling and the development of functional motile cilia.

Cow (Bovine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) interaction partners

  1. the essential role of NHERF2 in endothelial cell adhesion/migration and angiogenesis. [NHERF2]

Pig (Porcine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) interaction partners

  1. Analysis showed that SLC9A3R2 gene has the closest genetic relationship with the SLC9A3R2 gene of human; it is structured in 7 exons and 6 introns; tissue expression analysis indicated that SLC9A3R2 gene is differentially expressed in different tissues.

Mouse (Murine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) interaction partners

  1. NHERF2 is differentially distributed to lipid rafts in brush border membrane fractions of NHE3 (show SLC9A3 Proteins).

  2. involvement of NHERF2 in multiple apical regulatory processes and interactions with luminal contents

  3. NHERF2 is necessary for multiple aspects of acute regulation of NHE3 (show SLC9A3 Proteins) in intact mouse small intestine

  4. It was concluded that NHERF2 plays important roles in tethering NHE3 (show SLC9A3 Proteins) to a position near the terminal web and in second messenger inhibition of NHE3 (show SLC9A3 Proteins) in a signal- and segment-specific fashion.

  5. Lysophosphatidic acid (LPA) is a potent stimulant of NHE3 (show SLC9A3 Proteins) and fluid absorption in the intestine, signaling through LPA(5 (show LPAR5 Proteins)). Regulation by LPA(5 (show LPAR5 Proteins)) depends on its interaction with NHERF2.

  6. demonstration of the significance of SGK1 (show SGK1 Proteins) and NHERF2 as TRPV5 (show TRPV5 Proteins) modulators which are likely to participate in the regulation of calcium homeostasis by 1,25(OH)2D3

  7. the function of SIP-1/NHERF2 as an SRY (show SRY Proteins) cofactor during testis determination is conserved between human and mouse

  8. analysis of NHERF (show SLC9A3R1 Proteins) recognition by ERM (show ETV5 Proteins) proteins

  9. NHERF-2 and mGluR5 (show GRM5 Proteins) exhibit overlapping patterns of expression in mouse brain, where their association prolongs intracellular calcium mobilization by mGluR5 (show GRM5 Proteins) and promotes mGluR5 (show GRM5 Proteins)-mediated toxicity.

  10. NHERF-1 (show SLC9A3R1 Proteins) but not NHERF-2 in native intestinal epithelium is involved in the formation of CFTR (show CFTR Proteins)-containing functional complexes that serve to position CFTR (show CFTR Proteins) in the crypt apical membrane and to optimize its function as a cAMP- and cGMP-regulated anion channel

Human Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) interaction partners

  1. Moreover, the S303D mutation enhances the in vivo dynamics of the E3KARP tail alone, whereas in vitro the interaction of E3KARP with active ezrin (show EZR Proteins) is unaffected by S303D

  2. Lysophosphatidic acid stimulation of NHE3 (show SLC9A3 Proteins) exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK (show EPHB2 Proteins)-PLC (show HSPG2 Proteins)-PKCdelta (show PKCd Proteins) signaling.

  3. Data indicate that the tails promote different microvillar localizations for EBP50 (show SLC9A3R1 Proteins) and E3KARP, which localized along the full length and to the base of microvilli, respectively.

  4. Crystal structure of NHERF2 PDZ1 domain complex with C-terminal LPA2 (show LPAR2 Proteins) sequence. The PDZ1-LPA2 (show LPAR2 Proteins) binding specificity is achieved by hydrogen bonds and hydrophobic contacts with the last four LPA2 (show LPAR2 Proteins) residues contributing to specific interactions.

  5. NHERF2 domain was functionally significant in NHE3 (show SLC9A3 Proteins) regulation, being necessary for stimulation by lysophosphatidic acid of activity and increased mobility of NHE3 (show SLC9A3 Proteins)

  6. functional regulation of C3aR (show C3AR1 Proteins) by NHERFs in human mast cells

  7. AnxA2 (show ANXA2 Proteins) and NHERF2 form a scaffold complex that links adjacent Tir molecules at the plasma membrane forming a lattice that could be involved in retention and dissemination of other effectors at the bacterial attachment site.

  8. NHERF-2 is a negative regulator of endothelial proliferation and may have important roles in endothelial homeostasis and vascular modeling.

  9. CaMKII (show CAMK2G Proteins) inhibition of NHE3 (show SLC9A3 Proteins) reguires NHEF2.

  10. Data show that both NHERF2 and NHERF1 (show SLC9A3R1 Proteins) are involved in setting NHE3 (show SLC9A3 Proteins) activity.

Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Protein Profile

Protein Summary

This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with SLC9A3R2

  • solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 (slc9a3r1)
  • solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 (SLC9A3R2)
  • solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 (SLC9A3R2)
  • solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 (Slc9a3r2)
  • solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 (Slc9a3r2)
  • 0610011L07Rik protein
  • 1200011K07Rik protein
  • 2010007A20Rik protein
  • cb895 protein
  • E3KARP protein
  • NHE3RF2 protein
  • NHERF-2 protein
  • NHERF2 protein
  • OCTS2 protein
  • SIP-1 protein
  • SIP1 protein
  • slc9a3r2 protein
  • Sryip1 protein
  • TKA-1 protein
  • wu:fd20a02 protein
  • zgc:55541 protein
  • zgc:77629 protein

Protein level used designations for SLC9A3R2

Na(+)/H(+) exchange regulatory cofactor NHE-RF1 , nherf1 , solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2 , solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 , Na(+)/H(+) exchange regulatory cofactor NHE-RF2 , solute carrier family 9 isoform 3 regulator 2 , NHE3 kinase A regulatory protein E3KARP , SRY-interacting protein 1 , Sry interacting protein 1 , sodium-hydrogen exchanger regulatory factor 2 , sodium/hydrogen exchanger , solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2 , solute carrier family 9 isoform 3 regulator 2, isoform A; sodium/hydrogen exchanger , solute carrier family 9 isoform A3 regulatory factor 2 , tyrosine kinase activator protein 1 , NHE3 regulatory factor 2 , sodium/hydrogen exchanger 3 kinase A regulatory protein , NHERF-2 , SIP-1 , TKA-1 , PDZ domain containing protein NHERF-2 , PDZ domain-containing protein NHERF-2

GENE ID SPECIES
327272 Danio rerio
416550 Gallus gallus
479884 Canis lupus familiaris
694658 Macaca mulatta
768005 Bos taurus
100192448 Sus scrofa
65962 Mus musculus
9351 Homo sapiens
116501 Rattus norvegicus
100008813 Oryctolagus cuniculus
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