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Sorbitol dehydrogenase (SORD\; EC 188.8.131.52) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1\; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). Additionally we are shipping Sorbitol Dehydrogenase Antibodies (129) and Sorbitol Dehydrogenase Kits (27) and many more products for this protein.
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Human SORD Protein expressed in Escherichia coli (E. coli) - ABIN667008
Baker, Reeves, Hetherington, Aitken: Analysis of proteomic changes associated with sperm capacitation through the combined use of IPG-strip pre-fractionation followed by RP chromatography LC-MS/MS analysis. in Proteomics 2010
Show all 2 references for ABIN667008
Nicotine-induced reduced expression of Sord could be involved in impaired secretory functions of the epididymis.
Knockout mice had the highest sorbitol content among various genetic types including mice wwith human aldose reductase (show AKR1B1 Proteins).
The zinc-finger protein ZAC1 (show PLAGL1 Proteins) is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte.
One of the most striking changes involved sorbitol dehydrogenase, a key enzyme in the polyol pathway. Validation studies revealed dramatically increased sorbitol dehydrogenase concentrations and activity in adenomas and cancer cell lines, along with important changes in the expression of other enzymes in the same (AKR1B1 (show AKR1B1 Proteins)) and related (KHK (show KHK Proteins)) pathways.
The SDH level was significantly decreased in patients with proliferative compared with non-proliferative retinopathy in both insulin (show INS Proteins) and oral diabetic groups.
Thus, our findings suggest that the -888G > C polymorphism in the SORD gene is not involved in the pathogenesis of diabtic retinopathy in type 2 diabetes.
The expression of SORD is regulated by androgens in human prostate. In prostate cancer, increased immunostaining was associated with high Gleason patterns and high serum PSA (show PLAG1 Proteins) concentrations.
crystals of sorbitol dehydrogenase belong to the monoclinic C2 space group, with unit-cell parameters a = 145.9, b = 52.3, c = 169.0 A, beta = 101.8 degrees
Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme.
Results compare the catalytic mechanism of liver sorbitol dehydrogenase with wild-type and Glu154-->Cys (show DNAJC5 Proteins) forms of yeast xylitol dehydrogenase.
Sorbitol dehydrogenase (SORD\; EC 184.108.40.206) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1\; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995
, L-iditol 2-dehydrogenase
, mammalian sorbitol dehydrogenase homolog
, sorbitol dehydrogenase 1