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Sorcin Proteins (SRI)

SRI encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. Additionally we are shipping Sorcin Antibodies (37) and Sorcin Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SRI 6717 P30626
SRI 109552 Q6P069
Rat SRI SRI 683667  
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Top Sorcin Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,480.50
Details
Yeast Cricetulus griseus His tag   1 mg Log in to see 56 to 66 Days
$2,480.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Escherichia coli (E. coli) Human His tag   5 μg Log in to see 6 to 11 Days
$142.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SRI Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Top referenced Sorcin Proteins

  1. Human SRI Protein expressed in Escherichia coli (E. coli) - ABIN667371 : Landriscina, Laudiero, Maddalena, Amoroso, Piscazzi, Cozzolino, Monti, Garbi, Fersini, Pucci, Esposito: Mitochondrial chaperone Trap1 and the calcium binding protein Sorcin interact and protect cells against apoptosis induced by antiblastic agents. in Cancer research 2010 (PubMed)
    Show all 2 references for ABIN667371

  2. Human SRI Protein expressed in Baculovirus infected Insect Cells - ABIN2006222 : Brownawell, Creutz: Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII). in The Journal of biological chemistry 1997 (PubMed)

More Proteins for Sorcin (SRI) Interaction Partners

Pig (Porcine) Sorcin (SRI) interaction partners

  1. Foot-and-mouth disease virus VP1 as an interferon (show IFNA Proteins)-suppressor by interacting with sorcin.

Human Sorcin (SRI) interaction partners

  1. The authors verified that NS5A of hepatitis C virus interacted with sorcin through domain I of NS5A, and phosphorylation of the threonine residue 155 of sorcin played a crucial role in protein interaction.

  2. Drug resistance can be effectively reversed in cisplatin-resistance and adriamycin-resistant myeloma cells through delivery of siRNAs targeting sorcin.

  3. Sorcin is highly expressed in the heart and in the brain, and overexpressed in many cancer cells. [Review]

  4. Sorcin antibody as a possible predictive factor in conversion from radiologically isolated syndrome to multiple sclerosis: a preliminary study

  5. Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis.

  6. Key cellular signaling pathways were triggered by sorcin silencing in the drug resistance of human nasopharyngeal carcinoma.

  7. sorcin regulates epithelial-mesenchymal transition and cancer stem cells partly through E-cadherin and vascular endothelial growth factor expression.

  8. overexpression of sorcin increased the phosphorylation of CREB1 (show CREB1 Proteins) and the binding of CREB1 (show CREB1 Proteins) to the CRE sequence of mdr1/p-gp (show ABCB4 Proteins) promoter, and induced the expression of MDR1/P-gp (show ABCB4 Proteins)

  9. down-regulation of sorcin did not alter expression or function of P-gp (show ABCB4 Proteins), but induced cell apoptosis and chemosensitivity in K562/ A02 and MCF-7/A02

  10. The role of sorcin in multidrug resistance in cancer. [Review]

Mouse (Murine) Sorcin (SRI) interaction partners

  1. Regulation of calcium signaling and cardiac contractility by miR-1 regulated sorcin expression plays a fundamental role in the maintenance of normal cardiac function and in the pathogenesis of cardiac dysfunction.

  2. sorcin is a potent inhibitor of both spontaneous and ICa-triggered RyR activity and is kinetically capable of playing a role in terminating the positive feedback loop of Ca2 (show CA2 Proteins)+-induced Ca2 (show CA2 Proteins)+ release

  3. Data further define the role of sorcin in cardiac excitation-contraction coupling and highlight its negative regulation of sarcoplasmic reticulum calcium release.

  4. Interaction of calcium/calmodulin-dependent protein kinase IIdeltaC with sorcin indirectly modulates ryanodine receptor function in cardiac myocytes.

Sorcin (SRI) Protein Profile

Protein Summary

This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene.

Gene names and symbols associated with Sorcin Proteins (SRI)

  • sorcin (SRI)
  • sorcin (sri)
  • Sorcin (EDI_060410)
  • Sorcin (EDI_160670)
  • Sorcin (EDI_002860)
  • Sorcin (EDI_076560)
  • sorcin (CpipJ_CPIJ004933)
  • sorcin (CpipJ_CPIJ008581)
  • sorcin (Tsp_05707)
  • Sorcin (sorcn)
  • sorcin (Sri)
  • 2210417O06Rik protein
  • 2900070H08Rik protein
  • CP-22 protein
  • CP22 protein
  • SCN protein
  • Sor protein
  • SRI protein
  • V19 protein
  • zgc:64070 protein

Protein level used designations for Sorcin Proteins (SRI)

sorcin , Sorcin , 22 kDa protein , H_RG167B05.1 , calcium binding protein amplified in mutlidrug-resistant cells

GENE ID SPECIES
100514123 Sus scrofa
393344 Danio rerio
549421 Xenopus (Silurana) tropicalis
705215 Macaca mulatta
5879089 Entamoeba dispar SAW760
5883304 Entamoeba dispar SAW760
5883371 Entamoeba dispar SAW760
5886423 Entamoeba dispar SAW760
6036401 Culex quinquefasciatus
6040842 Culex quinquefasciatus
10913537 Trichinella spiralis
100037199 Xenopus laevis
100286583 Salmo salar
100302556 Ovis aries
100305213 Oncorhynchus mykiss
734407 Xenopus laevis
420538 Gallus gallus
463518 Pan troglodytes
6717 Homo sapiens
475220 Canis lupus familiaris
508319 Bos taurus
109552 Mus musculus
683667 Rattus norvegicus
100174725 Pongo abelii
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