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SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. Additionally we are shipping SORL1 Kits (7) and SORL1 Proteins (2) and many more products for this protein.
Showing 10 out of 88 products:
Human Monoclonal SORL1 Primary Antibody for ICC, IHC - ABIN1724674
Scherzer, Offe, Gearing, Rees, Fang, Heilman, Schaller, Bujo, Levey, Lah: Loss of apolipoprotein E receptor LR11 in Alzheimer disease. in Archives of neurology 2004
Show all 3 references for ABIN1724674
Human Polyclonal SORL1 Primary Antibody for EIA, IP - ABIN493474
Taira, Bujo, Hirayama, Yamazaki, Kanaki, Takahashi, Ishii, Miida, Schneider, Saito: LR11, a mosaic LDL receptor family member, mediates the uptake of ApoE-rich lipoproteins in vitro. in Arteriosclerosis, thrombosis, and vascular biology 2001
Show all 3 references for ABIN493474
Human Monoclonal SORL1 Primary Antibody for WB - ABIN1109104
Gabrielsson, Olofsson, Sjögren, Jernås, Elander, Lönn, Rudemo, Carlsson: Evaluation of reference genes for studies of gene expression in human adipose tissue. in Obesity research 2005
Show all 3 references for ABIN1109104
Human Monoclonal SORL1 Primary Antibody for IHC (fro), FACS - ABIN1109103
Shah, Yu: sorLA: sorting out APP. in Molecular interventions 2006
Show all 3 references for ABIN1109103
Fly (Calliphora) Monoclonal SORL1 Primary Antibody for IHC, WB - ABIN968899
Jacobsen, Madsen, Moestrup, Lund, Tommerup, Nykjaer, Sottrup-Jensen, Gliemann, Petersen: Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. in The Journal of biological chemistry 1997
Show all 3 references for ABIN968899
Human Monoclonal SORL1 Primary Antibody for IF, WB - ABIN968682
Posse De Chaves, Vance, Campenot, Kiss, Vance: Uptake of lipoproteins for axonal growth of sympathetic neurons. in The Journal of biological chemistry 2000
Show all 3 references for ABIN968682
Mouse (Murine) Polyclonal SORL1 Primary Antibody for ELISA, WB - ABIN184579
Jacobsen, Madsen, Jacobsen, Nielsen, Gliemann, Petersen: Activation and functional characterization of the mosaic receptor SorLA/LR11. in The Journal of biological chemistry 2001
Show all 2 references for ABIN184579
Cow (Bovine) Polyclonal SORL1 Primary Antibody for WB - ABIN374076
Kim, Lee, Lee, Kim, Song, Huh, Lee, Kim, Kim, Hong, Shim, Chang: Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking. in Biochemical and biophysical research communications 2010
Elevated sLR11 levels may increase the cardiovascular disease risk especially in subjects with delayed clearance of triglyceride-rich remnants, such as in familial hypercholesterolemia patients.
CLF-1 (show CRLF1 Antibodies), based on its binding site for CLC (show CLC Antibodies) and on two additional and independent sites for CNTFRalpha (show CNTFR Antibodies) and sorLA, is a key player in CLC (show CLC Antibodies) and CNTFRalpha (show CNTFR Antibodies) signaling and turnover.
Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma
sLR11 levels in humans are shown to positively correlate with body mass index and adiposity.
The findings of this study confirm that SORL1 is associated with Alzheimer's Disease and might be a potential tool for identifying Mild Cognitive Impairment subjects at high risk of conversion to lzheimer's Disease.
Study suggested a sex-moderated association of the SORL1 rs2070045 polymorphism and executive function in healthy elderly
Mutating recombinant human SORLA, disrupting retromer binding caused retrograde-sorting defect, endosomal accumulation, TGN (show TG Antibodies), depletion, and enhanced APP (show APP Antibodies) processing. Disrupting the GGA interaction increased Abeta (show APP Antibodies) via defective anterograde lysosomal targeting.
genetic polymorphism controls protein expression, which directly regulates the amount of Abeta (show APP Antibodies) peptides implicated in Alzheimer's disease
SORL1 may be implicated in the downstream pathology in AD.
SORL1 risk variants influenced microstructure of white matter tracts with known susceptibility in Alzheimer's disease with consistent effect from childhood onward and predicted lower levels of mRNA expression
Data strongly suggest an involvement of LR11 in mediating the harmful effects of a high-fat diet on CVD progression.
Mice lacking LR11 are protected from diet-induced obesity associated with an increased browning of white adipose tissue and hypermetabolism.
using massively parallel reporter assays, we dissect the enhancer activity of three liver eExons (SORL1 exon 17, TRAF3IP2 (show TRAF3IP2 Antibodies) exon 2, PPARG (show PPARG Antibodies) exon 6) at single nucleotide resolution in the mouse liver
Data indicate that activation of alpha(2A) adrenergic receptor (alpha(2A)AR (show ADRA2A Antibodies)) signaling disrupts transgenic amyloid precursor protein (APP (show APP Antibodies)) interaction with sorting-related receptor with A repeat (SorLA) in cells and brain.
SORLA-mediated trafficking of TrkB (show NTRK2 Antibodies) enhances the response of neurons to BDNF (show BDNF Antibodies).
SorLA acts as sorting receptor for the GDNF (show GDNF Antibodies)/GFRalpha1 (show GFRA1 Antibodies) complex, directing it from the cell surface to endosomes.
sLR11 regulates the hypoxia-enhanced adhesion of HSPCs via an uPAR (show PLAUR Antibodies)-mediated pathway that stabilizes the hematological pool size by controlling cell attachment to the BM niche.
SorLA expression might be critical not only for amyloid-related pathology but also for other cellular processes altered in Alzheimer disease.
overexpression of SorLA increased migration of THP-1 (show GLI2 Antibodies) monocytes to monocyte chemoattractant protein-1 (show CCL2 Antibodies) with a coincident increase in UPAR (show PLAUR Antibodies) expression.
Sorcs1 (show SORCS1 Antibodies) deficiency might be a common genetic risk factor underlying the predisposition to Alzheimer disease that is associated with type 2 diabetes.
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.
sortilin-related receptor, L(DLR class) A repeats containing
, sortilin-related receptor, L(DLR class) A repeats-containing
, sortilin-related receptor-like
, LDLR relative with 11 ligand-binding repeats
, low-density lipoprotein receptor relative with 11 ligand-binding repeats
, mosaic protein LR11
, sortilin-related receptor
, sorting protein-related receptor containing LDLR class A repeats