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anti-Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) Antibodies

SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. Additionally we are shipping SORL1 Kits (7) and SORL1 Proteins (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SORL1 6653 Q92673
SORL1 20660 O88307
SORL1 300652  
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Top anti-SORL1 Antibodies at antibodies-online.com

Showing 10 out of 88 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Mouse Goat Un-conjugated ELISA, WB ABIN184579 (0.3µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of LR11 on a rat cerebrum lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti-LR11 antibody. 50 μg Log in to see 5 to 6 Days
$205.42
Details
REACT_Fly Mouse Un-conjugated IHC, WB Western blot analysis of gp250. Lysates from rat cerebrum (5 µg/lane), S2 cells (7.5 µg/lane), and 0-12 hours Drosophila embryos (7.5 µg/lane) were probed with anti-gp250 at concentrations of 0.5 µg/ml (lane 1), 0.25 µg/ml (lane 2), and 0.125 µg/ml (lane 3). Anti-gp250 detects a band of ~250 kDa in S2 cells and a 250 kDa plus a 200 kDa in rat cerebrum and Drosophila embryos. gp250 immunochemical staining of 0-12 hour embryos. Formalin-fixed embryos kept in ethanol at -20°C, were re-hydrated and incubated with anti-gp250 at 1 µg/ml in TBST. After extensive washes to remove unbound antibody, gp250 signal was visualized with ALEXA fluor 488 secondary antibody (1/300) and confocal microscopy. gp250 staining is found troughout the the cellularizing embryo both in the cytoplasm and and somewhat higher levels in the nucleus. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Mouse Un-conjugated ELISA, WB 100 μL Log in to see 3 to 4 Days
$442.20
Details
Human Mouse Un-conjugated IHC (fro), FACS, IF, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ICC, IHC, ELISA, WB 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Rabbit Un-conjugated EIA, IP, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Mouse Un-conjugated WB 0.1 mL Log in to see 6 to 8 Days
$434.50
Details

SORL1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-SORL1 Antibodies

  1. Human Monoclonal SORL1 Primary Antibody for ICC, IHC - ABIN1724674 : Scherzer, Offe, Gearing, Rees, Fang, Heilman, Schaller, Bujo, Levey, Lah: Loss of apolipoprotein E receptor LR11 in Alzheimer disease. in Archives of neurology 2004 (PubMed)
    Show all 3 references for ABIN1724674

  2. Human Polyclonal SORL1 Primary Antibody for EIA, IP - ABIN493474 : Taira, Bujo, Hirayama, Yamazaki, Kanaki, Takahashi, Ishii, Miida, Schneider, Saito: LR11, a mosaic LDL receptor family member, mediates the uptake of ApoE-rich lipoproteins in vitro. in Arteriosclerosis, thrombosis, and vascular biology 2001 (PubMed)
    Show all 3 references for ABIN493474

  3. Human Monoclonal SORL1 Primary Antibody for WB - ABIN1109104 : Gabrielsson, Olofsson, Sjögren, Jernås, Elander, Lönn, Rudemo, Carlsson: Evaluation of reference genes for studies of gene expression in human adipose tissue. in Obesity research 2005 (PubMed)
    Show all 3 references for ABIN1109104

  4. Human Monoclonal SORL1 Primary Antibody for IHC (fro), FACS - ABIN1109103 : Shah, Yu: sorLA: sorting out APP. in Molecular interventions 2006 (PubMed)
    Show all 3 references for ABIN1109103

  5. Fly (Calliphora) Monoclonal SORL1 Primary Antibody for IHC, WB - ABIN968899 : Jacobsen, Madsen, Moestrup, Lund, Tommerup, Nykjaer, Sottrup-Jensen, Gliemann, Petersen: Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. in The Journal of biological chemistry 1997 (PubMed)
    Show all 3 references for ABIN968899

  6. Human Monoclonal SORL1 Primary Antibody for IF, WB - ABIN968682 : Posse De Chaves, Vance, Campenot, Kiss, Vance: Uptake of lipoproteins for axonal growth of sympathetic neurons. in The Journal of biological chemistry 2000 (PubMed)
    Show all 3 references for ABIN968682

  7. Mouse (Murine) Polyclonal SORL1 Primary Antibody for ELISA, WB - ABIN184579 : Jacobsen, Madsen, Jacobsen, Nielsen, Gliemann, Petersen: Activation and functional characterization of the mosaic receptor SorLA/LR11. in The Journal of biological chemistry 2001 (PubMed)
    Show all 2 references for ABIN184579

  8. Cow (Bovine) Polyclonal SORL1 Primary Antibody for WB - ABIN374076 : Kim, Lee, Lee, Kim, Song, Huh, Lee, Kim, Kim, Hong, Shim, Chang: Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking. in Biochemical and biophysical research communications 2010 (PubMed)

More Antibodies against SORL1 Interaction Partners

Human Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) interaction partners

  1. Elevated sLR11 levels may increase the cardiovascular disease risk especially in subjects with delayed clearance of triglyceride-rich remnants, such as in familial hypercholesterolemia patients.

  2. CLF-1 (show CRLF1 Antibodies), based on its binding site for CLC (show CLC Antibodies) and on two additional and independent sites for CNTFRalpha (show CNTFR Antibodies) and sorLA, is a key player in CLC (show CLC Antibodies) and CNTFRalpha (show CNTFR Antibodies) signaling and turnover.

  3. Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma

  4. sLR11 levels in humans are shown to positively correlate with body mass index and adiposity.

  5. The findings of this study confirm that SORL1 is associated with Alzheimer's Disease and might be a potential tool for identifying Mild Cognitive Impairment subjects at high risk of conversion to lzheimer's Disease.

  6. Study suggested a sex-moderated association of the SORL1 rs2070045 polymorphism and executive function in healthy elderly

  7. Mutating recombinant human SORLA, disrupting retromer binding caused retrograde-sorting defect, endosomal accumulation, TGN (show TG Antibodies), depletion, and enhanced APP (show APP Antibodies) processing. Disrupting the GGA interaction increased Abeta (show APP Antibodies) via defective anterograde lysosomal targeting.

  8. genetic polymorphism controls protein expression, which directly regulates the amount of Abeta (show APP Antibodies) peptides implicated in Alzheimer's disease

  9. SORL1 may be implicated in the downstream pathology in AD.

  10. SORL1 risk variants influenced microstructure of white matter tracts with known susceptibility in Alzheimer's disease with consistent effect from childhood onward and predicted lower levels of mRNA expression

Mouse (Murine) Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) interaction partners

  1. Data strongly suggest an involvement of LR11 in mediating the harmful effects of a high-fat diet on CVD progression.

  2. Mice lacking LR11 are protected from diet-induced obesity associated with an increased browning of white adipose tissue and hypermetabolism.

  3. using massively parallel reporter assays, we dissect the enhancer activity of three liver eExons (SORL1 exon 17, TRAF3IP2 (show TRAF3IP2 Antibodies) exon 2, PPARG (show PPARG Antibodies) exon 6) at single nucleotide resolution in the mouse liver

  4. Data indicate that activation of alpha(2A) adrenergic receptor (alpha(2A)AR (show ADRA2A Antibodies)) signaling disrupts transgenic amyloid precursor protein (APP (show APP Antibodies)) interaction with sorting-related receptor with A repeat (SorLA) in cells and brain.

  5. SORLA-mediated trafficking of TrkB (show NTRK2 Antibodies) enhances the response of neurons to BDNF (show BDNF Antibodies).

  6. SorLA acts as sorting receptor for the GDNF (show GDNF Antibodies)/GFRalpha1 (show GFRA1 Antibodies) complex, directing it from the cell surface to endosomes.

  7. sLR11 regulates the hypoxia-enhanced adhesion of HSPCs via an uPAR (show PLAUR Antibodies)-mediated pathway that stabilizes the hematological pool size by controlling cell attachment to the BM niche.

  8. SorLA expression might be critical not only for amyloid-related pathology but also for other cellular processes altered in Alzheimer disease.

  9. overexpression of SorLA increased migration of THP-1 (show GLI2 Antibodies) monocytes to monocyte chemoattractant protein-1 (show CCL2 Antibodies) with a coincident increase in UPAR (show PLAUR Antibodies) expression.

  10. Sorcs1 (show SORCS1 Antibodies) deficiency might be a common genetic risk factor underlying the predisposition to Alzheimer disease that is associated with type 2 diabetes.

SORL1 Antigen Profile

Protein Summary

This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.

Gene names and symbols associated with SORL1

  • sortilin-related receptor, L(DLR class) A repeats containing (sorl1) antibody
  • sortilin-related receptor, L(DLR class) A repeats-containing (SORL1) antibody
  • sortilin-related receptor, L(DLR class) A repeats-containing (LOC100226349) antibody
  • sortilin-related receptor, L(DLR class) A repeats-containing (sorl1) antibody
  • sortilin-related receptor, L(DLR class) A repeats containing (SORL1) antibody
  • sortilin-related receptor, LDLR class A repeats-containing (Sorl1) antibody
  • 2900010L19Rik antibody
  • AI596264 antibody
  • AW261561 antibody
  • C11orf32 antibody
  • gp250 antibody
  • Lr11 antibody
  • LRP9 antibody
  • mSorLA antibody
  • RGD619914 antibody
  • SORL1 antibody
  • SorLA antibody
  • SorLA-1 antibody

Protein level used designations for SORL1

sortilin-related receptor, L(DLR class) A repeats containing , sortilin-related receptor, L(DLR class) A repeats-containing , sortilin-related receptor-like , LDLR relative with 11 ligand-binding repeats , low-density lipoprotein receptor relative with 11 ligand-binding repeats , mosaic protein LR11 , sortilin-related receptor , sorting protein-related receptor containing LDLR class A repeats , LR11 , sorLA , sorLA-1

GENE ID SPECIES
100566946 Anolis carolinensis
582560 Strongylocentrotus purpuratus
713011 Macaca mulatta
100024063 Monodelphis domestica
100071572 Equus caballus
100073504 Ornithorhynchus anatinus
100226349 Taeniopygia guttata
100490681 Xenopus (Silurana) tropicalis
100524036 Sus scrofa
6653 Homo sapiens
479408 Canis lupus familiaris
533166 Bos taurus
395998 Gallus gallus
100009378 Oryctolagus cuniculus
20660 Mus musculus
300652 Rattus norvegicus
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