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SNX10 encodes a member of the sorting nexin family. Additionally we are shipping SNX10 Antibodies (26) and SNX10 Proteins (5) and many more products for this protein.
supplementation with calcium gluconate rescued mice from the rachitic phenotype and extended life span in global Snx10-deficient mice, suggesting that this may be a life-saving component of the clinical approach to Snx10-dependent human osteopetrosis (show CSF1 ELISA Kits)
Data suggest Tyr32 and Arg51 in SNX10 are important for protein stability and play critical roles in vacuolation in osteoclasts; mutation Arg16Leu (seen in autosomal recessive osteopetrosis (show CSF1 ELISA Kits) patients) affects protein-protein interactions of SNX10.
results confirm the involvement of the SNX10 gene in human ARO (show CYP19A1 ELISA Kits) and identify a new subset with a relatively favorable prognosis as compared to TCIRG1 (show TCIRG1 ELISA Kits)-dependent cases
Structure of sorting nexin 11 (SNX11 (show SNX11 ELISA Kits)) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation.
Identification of SNX10 as a new osteopetrosis (show CSF1 ELISA Kits) associated gene in consanguineous families of Palestinian origin.
SNX10 regulates the ciliary trafficking of Rab8a (show RAB8A ELISA Kits), which is a critical regulator of ciliary membrane extension.
SNX10 activity may be involved in the regulation of endosome homeostasis
data disclose a crucial role and novel function for SNX10 in macrophage polarization. Loss of SNX10 function may be a potential promising therapeutic strategy for IBD.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants.
sorting nexin 10
, sorting nexin-10