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SNX15 encodes a member of the sorting nexin family. Additionally we are shipping SNX15 Antibodies (54) and many more products for this protein.
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The activated EGF receptor (show EGFR Proteins) enters distinct sub-populations of SNX15- and APPL1 (show APPL1 Proteins)-labelled peripheral endocytic vesicles.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene.
sorting nexin 15
, clone iota unknown protein
, sorting nexin-15