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SNX27 encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. Additionally we are shipping SNX27 Proteins (5) and many more products for this protein.
Showing 10 out of 85 products:
Human Polyclonal SNX27 Primary Antibody for EIA, WB - ABIN954891
Nassirpour, Slesinger: Subunit-specific regulation of Kir3 channels by sorting nexin 27. in Channels (Austin, Tex.) 2008
Show all 4 references for 954891
Human Polyclonal SNX27 Primary Antibody for ICC, IF - ABIN4355011
Ish-Shalom, Meirow, Sade-Feldman, Kanterman, Wang, Mizrahi, Klieger, Baniyash: Impaired SNX9 Expression in Immune Cells during Chronic Inflammation: Prognostic and Diagnostic Implications. in Journal of immunology (Baltimore, Md. : 1950) 2015
This study defines specific acidic amino acid sequences upstream of the PDZ (show INADL Antibodies)-binding motif required for high-affinity engagement of the human SNX27 PDZ domain (show INADL Antibodies).
a function of SNX27 in regulating beta-amyloid (Abeta (show APP Antibodies)) generation by modulating gamma-secretase activity.
PTHR (show PTHLH Antibodies) recycles rapidly through at least two pathways, one involving the ASRT complex of actin, SNX27, and retromer and another possibly involving N-ethylmaleimide-sensitive factor (show NSF Antibodies).
SNX27 inhibits the Wnt regulated transcription activity of TCF/LEF. Our results suggested that SNX27 interacts with Frizzled receptors to regulate the endocytosis and stability of Fzds
SNX27 interaction with FAM21 is required for the precise localization of SNX27 at an endosomal subdomain.
SNX27 deficiency is now added to the growing list of neurodegenerative disorders associated with retromer dysfunction.
The results suggest that SNX27 undergoes dynamic partitioning between different membrane domains during immunological synapse assembly, and underscore the contribution of unique lipid interactions for SNX27 orchestration of cargo trafficking.
The double knockdown of SNX17 (show SNX17 Antibodies) and SNX27 results in a striking reduction of papillomavirus 16 infection due to interruption of their binding to the L2 viral protein.
RNAi-mediated suppression of ANKRD50 phenocopies loss of SNX27-retromer function.
VPS26A (show VPS26A Antibodies) binding increases the affinity of the SNX27 PDZ domain (show INADL Antibodies) for PDZ (show INADL Antibodies)- binding motifs by an order of magnitude, revealing cooperativity in cargo selection.
we anticipate that future study will determine whether modulation of a SNX27/Notch (show NOTCH1 Antibodies)/gamma-secretase pathway can also be of therapeutic interest to congenital hydrocephalus (show FOXC1 Antibodies)
We identify binding and trafficking interactions between two of these factors, SORLA (show SORL1 Antibodies) and SNX27, and demonstrate that SNX27 can direct trafficking of SORLA (show SORL1 Antibodies) and the Abeta (show APP Antibodies) precursor APP (show APP Antibodies) to the cell surface to limit the production of Abeta (show APP Antibodies). Diversion APP (show APP Antibodies) to the cell surface through modulation of this molecular complex may represent a complimentary strategy for future development in AD treatment.
A critical role for SNX27-retromer mediated transport of PTHR (show PTH1R Antibodies) in normal bone development.
SNX27-dependent mechanism of inhibitory plasticity in DA neurons is a potential intervention point for disorders of dopamine neurons.
SNX27 associates with ZO-2 (show TJP2 Antibodies) and modulates the epithelial tight junction.
a model by which SNX27 regulates trafficking of beta-Pix (show ARHGEF7 Antibodies) to focal adhesions and thereby influences cell motility.
indicate that SNX27 may function to regulate endocytosis and/or endosomal sorting of NR2C (show GRIN2C Antibodies)
SNX27 and NHERF (show SLC9A3R1 Antibodies) specifically interact with the 5-HT4a receptor splice variant
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
methamphetamine-responsive transcript 1
, sorting nexin-27
, MAP-responsive gene protein
, PDZ protein Mrt1
, PDZ-protein Mrt1
, methamphetamine (MAP) responsive transcript 1
, methamphetamine-responsive transcript 1 protein