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SNX27 encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. Additionally we are shipping SNX27 Antibodies (84) and many more products for this protein.
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This study defines specific acidic amino acid sequences upstream of the PDZ-binding motif required for high-affinity engagement of the human SNX27 PDZ domain.
a function of SNX27 in regulating beta-amyloid (Abeta (show APP Proteins)) generation by modulating gamma-secretase activity.
PTHR recycles rapidly through at least two pathways, one involving the ASRT complex of actin, SNX27, and retromer and another possibly involving N-ethylmaleimide-sensitive factor (show NSF Proteins).
SNX27 inhibits the Wnt regulated transcription activity of TCF/LEF. Our results suggested that SNX27 interacts with Frizzled receptors to regulate the endocytosis and stability of Fzds
SNX27 interaction with FAM21 is required for the precise localization of SNX27 at an endosomal subdomain.
SNX27 deficiency is now added to the growing list of neurodegenerative disorders associated with retromer dysfunction.
The results suggest that SNX27 undergoes dynamic partitioning between different membrane domains during immunological synapse assembly, and underscore the contribution of unique lipid interactions for SNX27 orchestration of cargo trafficking.
The double knockdown of SNX17 (show SNX17 Proteins) and SNX27 results in a striking reduction of papillomavirus 16 infection due to interruption of their binding to the L2 viral protein.
RNAi-mediated suppression of ANKRD50 phenocopies loss of SNX27-retromer function.
VPS26A binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnitude, revealing cooperativity in cargo selection.
A critical role for SNX27-retromer mediated transport of PTHR (show PTH1R Proteins) in normal bone development.
SNX27-dependent mechanism of inhibitory plasticity in DA neurons is a potential intervention point for disorders of dopamine neurons.
SNX27 associates with ZO-2 (show TJP2 Proteins) and modulates the epithelial tight junction.
a model by which SNX27 regulates trafficking of beta-Pix (show ARHGEF7 Proteins) to focal adhesions and thereby influences cell motility.
indicate that SNX27 may function to regulate endocytosis and/or endosomal sorting of NR2C (show GRIN2C Proteins)
SNX27 and NHERF (show SLC9A3R1 Proteins) specifically interact with the 5-HT4a receptor splice variant
These data support a previously unreported role for diacylglycerol kinase zeta (show DGKZ Proteins) in the modulation of membrane trafficking, which may also help to define SNX27 function.
This study shows that SNX27 promotes the endosomal movement of Kir3 (or GIRK) channels, leading to reduced surface expression, increased degradation and smaller Kir3 potassium currents.
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
methamphetamine-responsive transcript 1
, sorting nexin-27
, MAP-responsive gene protein
, PDZ protein Mrt1
, PDZ-protein Mrt1
, methamphetamine (MAP) responsive transcript 1
, methamphetamine-responsive transcript 1 protein