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SAMM50 encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. Additionally we are shipping Sorting and Assembly Machinery Component 50 Homolog Antibodies (41) and many more products for this protein.
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SAMM50 affects the Drp1-dependent mitochondrial morphology.
downregulation of SAM50 in BCR-ABL (show ABL1 Proteins)-expressing, but not normal CD34 (show CD34 Proteins)(+) human hematopoietic stem and progenitor cells (HSPCs) caused a significant decrease in growth, colony formation, and replating capacity.
the integrity of MICOS and its efficient interaction with Sam50 are indispensable for cristae organization, which is relevant to mitochondrial function.
Polymorphisms in the SAMM50 and PARVB genes in addition to those in the PNPLA3 gene were observed to be associated with the development and progression of NAFLD.
The study describes a novel role of SAM50 in maintaining the mitochondrial shape and the morphology of cristae.
The pathway of Voltage-dependent anion-selective channel biogenesis in human mitochondria involves the TOM complex, Sam50 and metaxins, and that it is evolutionarily conserved.
mitofilin helps regulate mitochondrial morphology and at least four of the associated proteins (metaxins 1 and 2, SAM50 and CHCHD3 (show CHCHD3 Proteins)) have been implicated in protein import
This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane.
sorting and assembly machinery component 50 homolog
, sorting and assembly machinery 50kDa
, transformation-related gene 3 protein
, sorting and assembly machinery component 50 homolog A