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The protein encoded by SP1 is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. Additionally we are shipping SP1 Kits (21) and SP1 Proteins (9) and many more products for this protein.
Showing 10 out of 284 products:
Human Polyclonal SP1 Primary Antibody for ChIP, WB - ABIN2668968
Wang, Mayhew, Chen, Johnston, Mitra: "Calling cards" for DNA-binding proteins in mammalian cells. in Genetics 2012
Show all 5 references for ABIN2668968
Human Polyclonal SP1 Primary Antibody for EIA, FACS - ABIN954894
Mucha, Ooi, Linley, Mordaka, Dalle, Robertson, Gamper, Wood: Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Show all 5 references for ABIN954894
Human Polyclonal SP1 Primary Antibody for FACS, IF - ABIN655398
Pan, Yang, Wei, Sun, Li: SP1 acts as a key factor, contributes to upregulation of ADAM23 expression under serum deprivation. in Biochemical and biophysical research communications 2010
Show all 4 references for ABIN655398
Human Monoclonal SP1 Primary Antibody for WB - ABIN1944791
Takahara, Kanazu, Yanagisawa, Akanuma: Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing. in The Journal of biological chemistry 2000
Show all 2 references for ABIN1944791
Cow (Bovine) Polyclonal SP1 Primary Antibody for EIA, WB - ABIN782966
Wan, Carr, Cutler, Lanza, Hines, Yost: Sp1 and Sp3 regulate basal transcription of the human CYP2F1 gene. in Drug metabolism and disposition: the biological fate of chemicals 2005
Human Polyclonal SP1 Primary Antibody for IF, IHC - ABIN1533004
Kadonaga, Carner, Masiarz, Tjian: Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. in Cell 1988
Mouse (Murine) Polyclonal SP1 Primary Antibody for WB - ABIN2779991
Hsu, Chang, Hung: HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. in The Journal of biological chemistry 2006
Human Polyclonal SP1 Primary Antibody for ELISA, WB - ABIN185433
Sakuntabhai, Turbpaiboon, Casadémont, Chuansumrit, Lowhnoo, Kajaste-Rudnitski, Kalayanarooj, Tangnararatchakit, Tangthawornchaikul, Vasanawathana, Chaiyaratana, Yenchitsomanus, Suriyaphol, Avirutnan et al.: A variant in the CD209 promoter is associated with severity of dengue disease. ... in Nature genetics 2005
Chicken Polyclonal SP1 Primary Antibody for WB - ABIN2773827
Yoshimura, Kimura, Ishii, Ishii, Matsuura, Geshi, Hosokawa, Muramatsu: Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites. in Biochemical and biophysical research communications 2008
A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Antibodies), sp1 and sod1 (show SOD1 Antibodies) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
we verified that miR (show MLXIP Antibodies)-892b regulates the p19ARF (show CDKN2A Antibodies)/cyclin D1 (show CCND1 Antibodies)/CDK6 (show CDK6 Antibodies) and Sp-1 (show PSG1 Antibodies)/MMP-9 (show MMP9 Antibodies) signaling networks in bladder cancer cells and may provide a treatment option for advanced-stage bladder cancers.
Study provides evidence that Mef2c (show MEF2C Antibodies) cooperated with Sp1 (show PSG1 Antibodies) to activate human AQP1 (show AQP1 Antibodies) transcription by binding to its proximal promoter in human umbilical cord vein endothelial cells indicating that AQP1 (show AQP1 Antibodies) is a direct target of Mef2c (show MEF2C Antibodies) in regulating angiogenesis and vasculogenesis of endothelial cells.
MiR (show MLXIP Antibodies)-375 inhibited the proliferation, invasion and migration by directly targeting SP1 (show PSG1 Antibodies).
High SP1 (show PSG1 Antibodies) expression is associated with ovarian cancer.
miR (show MLXIP Antibodies)-326 can restore CDDP chemosensitivity in the human lung adenocarcinoma cells by targeting SP1 (show PSG1 Antibodies), and HOTAIR upregulate the expression of miR (show MLXIP Antibodies)-326 target gene SP1 (show PSG1 Antibodies).
TEAD1 (show TEAD1 Antibodies) could enhance the expression levels of SP1 (show PSG1 Antibodies), by directly binding to its promoter.
site-directed mutagenesis of potential SP1 (show PSG1 Antibodies) binding sites diminished both DNA-protein complexes and SP1 (show PSG1 Antibodies)-mediated upregulation of URG-4 (show URGCP Antibodies) promoter activity. These findings are valuable for understanding transcriptional regulation of URG4/URGCP (show URGCP Antibodies) that has a pivotal role in cancer progression.
Sp1 (show PSG1 Antibodies) up-regulated TMEPAI (show PMEPA1 Antibodies) protein expression, as well as Sp1 (show PSG1 Antibodies) promoting TMEPAI (show PMEPA1 Antibodies)-induced cell proliferation.
the results of this study suggest that the miR (show MLXIP Antibodies)-24/SP1 (show PSG1 Antibodies) pathway contributed to the reduction in radioresistance in human NPC (show NPC1 Antibodies) and that it may thus represent a therapeutic target.
we predicted CG-rich region of miR (show MLXIP Antibodies)-23a-27a-24-2 cluster (miR (show MLXIP Antibodies)-23a, miR (show MLXIP Antibodies)-27a, and miR (show MLXIP Antibodies)-24-2)promoter and detected the methylation status in the region spanning two SP1 (show PSG1 Antibodies) sites.
study demonstrates the co-expression of DLX3 (show DLX3 Antibodies), PPARG (show PPARG Antibodies) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (show PTH Antibodies) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN (show FASN Antibodies) promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (show PRNP Antibodies) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Antibodies) promoter and its activity.
miR (show MLXIP Antibodies)-124, -128, and -137 act synergistically to regulate Sp1 expression.
YY1 (show YY1 Antibodies) and SP1 independently and cooperatively govern the Mesp1 (show MESP1 Antibodies) expression during embryogenesis.
Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 (show COL11A1 Antibodies) gene in chondrocytes.
In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 Antibodies) gene was regulated by E2F1 (show E2F1 Antibodies) and Sp1, and was then gradually replaced under the control of both MyoD (show MYOD1 Antibodies) and myogenin (show MYOG Antibodies).
Data indicate that Sp1 and AP-1 (show JUN Antibodies)-related factors are involved in the regulation of MFG-E8 (show MFGE8 Antibodies) gene transcription by targeting their binding sites in the 5'-flanking region under physiological and inflammatory states.
Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor (show SP3 Antibodies) members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
age-dependent alteration in the Fmr-1 (show FMR1 Antibodies) gene expression is associated with Sp1 interaction with Fmr-1 (show FMR1 Antibodies) promoter which in turn might be related with cognitive development during brain maturation and aging.
The results of this study suggest that SP4 and SP1 upregulation may be part of the mechanisms deregulated downstream of glutamate (show GRIN1 Antibodies) signalling pathways in schizophrenia
The transcription factor SP1 is induced in brain by ischemia/reperfusion.
Data suggest that retinoic acid and GM-CSF (show CSF2 Antibodies)-induced retinal dehydrogenase 2 (RALDH2 (show ALDH1A2 Antibodies)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 via the RA receptor/retinoid X receptor (show RXRB Antibodies) complex to the Aldh1a2 (show ALDH1A1 Antibodies) promoter.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1