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anti-Sp1 Transcription Factor (SP1) Antibodies

The protein encoded by SP1 is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. Additionally we are shipping SP1 Kits (25) and SP1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SP1 6667 P08047
SP1 24790 Q01714
SP1 20683 O89090
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Top anti-SP1 Antibodies at

Showing 10 out of 228 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB SP1 Antibody (C-term P692) (ABIN655398) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
Mouse Rabbit Un-conjugated WB WB Suggested Anti-SP1 Antibody Titration: 2.5ug/mlELISA Titer: 1:312500Positive Control: NIH/3T3 cell lysate 100 μL Log in to see 2 to 3 Days
Human Goat Un-conjugated ELISA, WB ABIN185433 staining (0.3µg/ml) of Hela lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 4 to 5 Days
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from HT-29 cells, using SP1 (Ab-739) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using SP1 (Ab-739) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-SP1 Antibody Titration: 1.25ug/mlELISA Titer: 1:1562500Positive Control: SP2/0 cell lysate 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ChIP, WB Sp1 antibody tested by ChIP. Chromatin immunoprecipitation (ChIP) was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with 20 µg of chromatin from B cell lymphoma Namalwa cells and 6 µl of Sp1 antibody. ChIP DNA was used in qPCR with the control primer pairs or gene-specific primer pairs as indicated. Data are presented as Binding Events Detected per 1000 Cells using Active Motif's Epigenetic Services normalization scheme which accounts for primer efficiency and the amount of chromatin used in the ChIP reaction. Sp1 antibody tested by Western blot. Detection of Sp1 by Western blot analysis. Sp1 was detected in nuclear extracts derived from K-562 cells using Sp1 rabbit polyclonal antibody at a 1:1,000 dilution. 100 μL Log in to see 1 to 2 Days
Human Mouse Un-conjugated WB 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated WB Anti-SP1 antibody, Western blotting All lanes: Anti SP1  at 0.5ug/ml WB: HELA Whole Cell Lysate at 40ug Predicted bind size: 81KD Observed bind size: 81KD 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 2 to 3 Days

SP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SP1 Antibodies

  1. Human Polyclonal SP1 Primary Antibody for ChIP, WB - ABIN2668968 : Wang, Mayhew, Chen, Johnston, Mitra: "Calling cards" for DNA-binding proteins in mammalian cells. in Genetics 2012 (PubMed)
    Show all 5 references for ABIN2668968

  2. Human Polyclonal SP1 Primary Antibody for FACS, IF - ABIN655398 : Pan, Yang, Wei, Sun, Li: SP1 acts as a key factor, contributes to upregulation of ADAM23 expression under serum deprivation. in Biochemical and biophysical research communications 2010 (PubMed)
    Show all 4 references for ABIN655398

  3. Human Monoclonal SP1 Primary Antibody for WB - ABIN1944791 : Takahara, Kanazu, Yanagisawa, Akanuma: Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN1944791

  4. Cow (Bovine) Polyclonal SP1 Primary Antibody for WB - ABIN2779990 : Hsu, Chang, Hung: HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. in The Journal of biological chemistry 2006 (PubMed)

  5. Human Polyclonal SP1 Primary Antibody for IF, IHC - ABIN1533004 : Kadonaga, Carner, Masiarz, Tjian: Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. in Cell 1988 (PubMed)

  6. Chicken Polyclonal SP1 Primary Antibody for WB - ABIN2773827 : Yoshimura, Kimura, Ishii, Ishii, Matsuura, Geshi, Hosokawa, Muramatsu: Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites. in Biochemical and biophysical research communications 2008 (PubMed)

  7. Human Polyclonal SP1 Primary Antibody for ELISA, WB - ABIN185433 : Sakuntabhai, Turbpaiboon, Casadémont, Chuansumrit, Lowhnoo, Kajaste-Rudnitski, Kalayanarooj, Tangnararatchakit, Tangthawornchaikul, Vasanawathana, Chaiyaratana, Yenchitsomanus, Suriyaphol, Avirutnan et al.: A variant in the CD209 promoter is associated with severity of dengue disease. ... in Nature genetics 2005 (PubMed)

More Antibodies against SP1 Interaction Partners

Zebrafish Sp1 Transcription Factor (SP1) interaction partners

  1. A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Antibodies), sp1 and sod1 (show SOD1 Antibodies) in zebrafish.

  2. zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1

Human Sp1 Transcription Factor (SP1) interaction partners

  1. Ginsenoside Rg3 induces FUT4 (show FUT4 Antibodies)-mediated apoptosis in H. pylori CagA (show S100A8 Antibodies)-treated gastric cancer cells by regulating SP1 (show PSG1 Antibodies) and HSF1 (show HSF1 Antibodies) expressions

  2. miR (show MLXIP Antibodies)-23b/SP1 (show PSG1 Antibodies)/c-myc (show MYC Antibodies) forms a feed-forward loop supporting multiple myeloma cell growth

  3. these data indicate that activation of EGFR (show EGFR Antibodies) enhanced the expression of P2X7R (show P2RX7 Antibodies) in neuroblastoma (show ARHGEF16 Antibodies) cells lacking trophic support, being PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/PKC (show PRRT2 Antibodies) signaling pathway and Sp1 (show PSG1 Antibodies) mediating this pro-survival outcome

  4. This is the first study indicating that Sp1 (show PSG1 Antibodies) signaling plays an important role in the regulation of human LRRK2 (show LRRK2 Antibodies) gene expression.

  5. The cross-talk between SP1 (show PSG1 Antibodies) and p65 (show GORASP1 Antibodies), and the positive feedback regulatory loop of PI3-K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling by EP4 (show PTGER4 Antibodies) contribute to the overall responses of solamargine in this process

  6. These results suggest that STAT6 (show STAT6 Antibodies) plays an important role in regulating Sp1 (show PSG1 Antibodies) and BCL6 (show BCL6 Antibodies) through STAT2 (show STAT2 Antibodies) to exert the anti-proliferative effects of type I IFN.

  7. Binding of Sp1 (show PSG1 Antibodies) to the 5' splice site region had an inhibitory effect on L4-22K-activated major late promoter transcription.

  8. TRIM22 (show TRIM22 Antibodies) acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 (show PSG1 Antibodies) binding to the HIV-1 promoter

  9. Identify SP1 (show PSG1 Antibodies) and PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling as modulators of EWS (show EWSR1 Antibodies)/FLI1 (show FLI1 Antibodies) gene expression in tumor cell lines.

  10. AHR (show AHR Antibodies) promoter variant modulates its transcription and downstream effectors by allele-specific AHR (show AHR Antibodies)-SP1 (show PSG1 Antibodies) interaction functioning as a genetic marker for vitiligo (show MITF Antibodies)

Cow (Bovine) Sp1 Transcription Factor (SP1) interaction partners

  1. study demonstrates the co-expression of DLX3 (show DLX3 Antibodies), PPARG (show PPARG Antibodies) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation

  2. likely involvement of the Sp family in regulating PTH (show PTH Antibodies) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.

  3. These results demonstrate that the single nucleotide polymorphism alters the bovine FASN (show FASN Antibodies) promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.

  4. The coordinate regulation of the bovine PRNP (show PRNP Antibodies) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Antibodies) promoter and its activity.

Pig (Porcine) Sp1 Transcription Factor (SP1) interaction partners

  1. Data indicate that higher hepatic glucocorticoid receptor (GR (show NR3C1 Antibodies)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (show TP53 Antibodies) and specificity protein 1 (Sp1).

  2. transcription factor Sp1 interacts with nucleotides -123/-114, indicating that Sp1 could play a key role in the transcriptional regulation of pig CAV-1 (show CAV1 Antibodies)

  3. Viral non-structural protein 1 suppressed host TNF-alpha (show TNF Antibodies) promoter by inhibiting NF-kappaB (show NFKB1 Antibodies) and Sp1 promoter binding activity.

  4. Basal transcription and supra-additive stimulation of porcine LDLR (show LDLR Antibodies) gene transcription by LH and insulin (show INS Antibodies) in granulosa-luteal cells require SREBP-1a and Sp1/Sp3 (show SP3 Antibodies)-binding elements.

  5. LH and insulin (show INS Antibodies) stimulate transcription of -976/+31 bp 5 (show HSPD1 Antibodies)'-upstream cis (show CISH Antibodies)-acting region of porcine CYP17 (show CYP17A1 Antibodies) gene. Maximal transcriptional responsiveness requires proximal Sp1 and AP-2-like (show TFAP2D Antibodies) sequences -193 to -180 bp 5 (show HSPD1 Antibodies)' upstream of transcriptional start site.

  6. KLF13 (show KLF13 Antibodies) and SREBP-Sp1 activation interact to regulate low density lipoprotein receptor (show LDLR Antibodies) promoter function

  7. SP1 and SMAD3 (show SMAD3 Antibodies) are required for high glucose-induced p21(WAF1 (show CDKN1A Antibodies)) gene transcription in LLC-PK1 (show PKLR Antibodies) cells.

Mouse (Murine) Sp1 Transcription Factor (SP1) interaction partners

  1. In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 Antibodies) gene was regulated by E2F1 (show E2F1 Antibodies) and Sp1, and was then gradually replaced under the control of both MyoD (show MYOD1 Antibodies) and myogenin (show MYOG Antibodies).

  2. Data indicate that Sp1 and AP-1 (show JUN Antibodies)-related factors are involved in the regulation of MFG-E8 (show MFGE8 Antibodies) gene transcription by targeting their binding sites in the 5'-flanking region under physiological and inflammatory states.

  3. Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor (show SP3 Antibodies) members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.

  4. age-dependent alteration in the Fmr-1 (show FMR1 Antibodies) gene expression is associated with Sp1 interaction with Fmr-1 (show FMR1 Antibodies) promoter which in turn might be related with cognitive development during brain maturation and aging.

  5. The results of this study suggest that SP4 and SP1 upregulation may be part of the mechanisms deregulated downstream of glutamate (show GRIN1 Antibodies) signalling pathways in schizophrenia

  6. The transcription factor SP1 is induced in brain by ischemia/reperfusion.

  7. Data suggest that retinoic acid and GM-CSF (show CSF2 Antibodies)-induced retinal dehydrogenase 2 (RALDH2 (show ALDH1A2 Antibodies)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 via the RA receptor/retinoid X receptor (show RXRB Antibodies) complex to the Aldh1a2 (show ALDH1A1 Antibodies) promoter.

  8. Sp1/Sp3 (show SP3 Antibodies) transcription factors have roles in regulating hallmarks of megakaryocyte maturation and platelet formation and function

  9. Our findings suggest that an SOHLH2 (show SOHLH2 Antibodies)/SOHLH1 (show SOHLH1 Antibodies)/SP1 ternary complex autonomously and cooperatively regulates Sohlh1 (show SOHLH1 Antibodies) gene transcription through juxtaposed E- and GC-boxes during early spermatogenesis and oogenesis.

  10. Results identify Sp1 as an inhibitor of DsbA-L (show GSTK1 Antibodies) gene transcription, and the Sp1-mediated inhibition of DsbA-L (show GSTK1 Antibodies) gene expression may provide a mechanism underlying obesity-induced adiponectin (show ADIPOQ Antibodies) downregulation and insulin (show INS Antibodies) resistance.

SP1 Antigen Profile

Protein Summary

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SP1

  • sp1 transcription factor (sp1) antibody
  • Sp1 transcription factor (sp1) antibody
  • Sp1 transcription factor (SP1) antibody
  • Sp1 transcription factor (LOC100351317) antibody
  • Sp1 transcription factor (Sp1) antibody
  • trans-acting transcription factor 1 (Sp1) antibody
  • 1110003E12Rik antibody
  • AA450830 antibody
  • AI845540 antibody
  • fc18h09 antibody
  • SP1 antibody
  • Sp1-1 antibody
  • wu:fc18h09 antibody
  • zgc:85950 antibody

Protein level used designations for SP1

Sp1-like protein , transcription factor Sp1 , transcription factor , Sp1 transcription factor , transcription factor Sp1-like , specificity protein 1 , specific protein-1 , trans-acting transcription factor 1

324109 Danio rerio
394744 Xenopus (Silurana) tropicalis
451939 Pan troglodytes
702710 Macaca mulatta
100351317 Oryctolagus cuniculus
100407824 Callithrix jacchus
100440745 Pongo abelii
100474983 Ailuropoda melanoleuca
100553756 Anolis carolinensis
100585963 Nomascus leucogenys
6667 Homo sapiens
540741 Bos taurus
24790 Rattus norvegicus
397314 Sus scrofa
431939 Xenopus laevis
395303 Gallus gallus
486507 Canis lupus familiaris
100303456 Ovis aries
20683 Mus musculus
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