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The protein encoded by SP1 is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. Additionally we are shipping SP1 Kits (25) and SP1 Proteins (8) and many more products for this protein.
Showing 10 out of 221 products:
Human Polyclonal SP1 Primary Antibody for ChIP, WB - ABIN2668968
Wang, Mayhew, Chen, Johnston, Mitra: "Calling cards" for DNA-binding proteins in mammalian cells. in Genetics 2012
Show all 5 references for ABIN2668968
Human Polyclonal SP1 Primary Antibody for FACS, IF - ABIN655398
Pan, Yang, Wei, Sun, Li: SP1 acts as a key factor, contributes to upregulation of ADAM23 expression under serum deprivation. in Biochemical and biophysical research communications 2010
Show all 4 references for ABIN655398
Human Monoclonal SP1 Primary Antibody for WB - ABIN1944791
Takahara, Kanazu, Yanagisawa, Akanuma: Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing. in The Journal of biological chemistry 2000
Show all 2 references for ABIN1944791
Cow (Bovine) Polyclonal SP1 Primary Antibody for WB - ABIN2779990
Hsu, Chang, Hung: HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. in The Journal of biological chemistry 2006
Human Polyclonal SP1 Primary Antibody for IF, IHC - ABIN1533004
Kadonaga, Carner, Masiarz, Tjian: Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. in Cell 1988
Chicken Polyclonal SP1 Primary Antibody for WB - ABIN2773827
Yoshimura, Kimura, Ishii, Ishii, Matsuura, Geshi, Hosokawa, Muramatsu: Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites. in Biochemical and biophysical research communications 2008
Human Polyclonal SP1 Primary Antibody for ELISA, WB - ABIN185433
Sakuntabhai, Turbpaiboon, Casadémont, Chuansumrit, Lowhnoo, Kajaste-Rudnitski, Kalayanarooj, Tangnararatchakit, Tangthawornchaikul, Vasanawathana, Chaiyaratana, Yenchitsomanus, Suriyaphol, Avirutnan et al.: A variant in the CD209 promoter is associated with severity of dengue disease. ... in Nature genetics 2005
A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Antibodies), sp1 and sod1 (show SOD1 Antibodies) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
The cross-talk between SP1 (show PSG1 Antibodies) and p65 (show GORASP1 Antibodies), and the positive feedback regulatory loop of PI3-K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling by EP4 (show PTGER4 Antibodies) contribute to the overall responses of solamargine in this process
These results suggest that STAT6 (show STAT6 Antibodies) plays an important role in regulating Sp1 (show PSG1 Antibodies) and BCL6 (show BCL6 Antibodies) through STAT2 (show STAT2 Antibodies) to exert the anti-proliferative effects of type I IFN.
Binding of Sp1 (show PSG1 Antibodies) to the 5' splice site region had an inhibitory effect on L4-22K-activated major late promoter transcription.
TRIM22 (show TRIM22 Antibodies) acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 (show PSG1 Antibodies) binding to the HIV-1 promoter
Identify SP1 (show PSG1 Antibodies) and PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling as modulators of EWS (show EWSR1 Antibodies)/FLI1 (show FLI1 Antibodies) gene expression in tumor cell lines.
AHR (show AHR Antibodies) promoter variant modulates its transcription and downstream effectors by allele-specific AHR (show AHR Antibodies)-SP1 (show PSG1 Antibodies) interaction functioning as a genetic marker for vitiligo (show MITF Antibodies)
In conclusion, these results indicate that Manu A is a potential to treat human oral squamous cell carcinoma via cell apoptosis through the downregulation of Sp1 (show PSG1 Antibodies).
High co-expression of Sp1 (show PSG1 Antibodies) and HER-2 (show ERBB2 Antibodies) is correlated with gastric cancer.
Sp1 (show PSG1 Antibodies) and Sp3 (show SP3 Antibodies) are not only essential for the basal transcription of the ek1 (show EPHA3 Antibodies) gene, their accessibility to the target site on the ek1 (show EPHA3 Antibodies) promoter is regulated by histone protein modification in a cell line dependent manner.
data suggests that CYP1B1 (show CYP1B1 Antibodies) promotes cell proliferation and metastasis by inducing EMT (show ITK Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling via Sp1 (show PSG1 Antibodies) induction
study demonstrates the co-expression of DLX3 (show DLX3 Antibodies), PPARG (show PPARG Antibodies) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (show PTH Antibodies) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN (show FASN Antibodies) promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (show PRNP Antibodies) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Antibodies) promoter and its activity.
Data indicate that higher hepatic glucocorticoid receptor (GR (show NR3C1 Antibodies)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (show TP53 Antibodies) and specificity protein 1 (Sp1).
transcription factor Sp1 interacts with nucleotides -123/-114, indicating that Sp1 could play a key role in the transcriptional regulation of pig CAV-1 (show CAV1 Antibodies)
Viral non-structural protein 1 suppressed host TNF-alpha (show TNF Antibodies) promoter by inhibiting NF-kappaB (show NFKB1 Antibodies) and Sp1 promoter binding activity.
Basal transcription and supra-additive stimulation of porcine LDLR (show LDLR Antibodies) gene transcription by LH and insulin (show INS Antibodies) in granulosa-luteal cells require SREBP-1a and Sp1/Sp3 (show SP3 Antibodies)-binding elements.
LH and insulin (show INS Antibodies) stimulate transcription of -976/+31 bp 5 (show HSPD1 Antibodies)'-upstream cis (show CISH Antibodies)-acting region of porcine CYP17 (show CYP17A1 Antibodies) gene. Maximal transcriptional responsiveness requires proximal Sp1 and AP-2-like (show TFAP2D Antibodies) sequences -193 to -180 bp 5 (show HSPD1 Antibodies)' upstream of transcriptional start site.
KLF13 (show KLF13 Antibodies) and SREBP-Sp1 activation interact to regulate low density lipoprotein receptor (show LDLR Antibodies) promoter function
SP1 and SMAD3 (show SMAD3 Antibodies) are required for high glucose-induced p21(WAF1 (show CDKN1A Antibodies)) gene transcription in LLC-PK1 (show PKLR Antibodies) cells.
In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 Antibodies) gene was regulated by E2F1 (show E2F1 Antibodies) and Sp1, and was then gradually replaced under the control of both MyoD (show MYOD1 Antibodies) and myogenin (show MYOG Antibodies).
Data indicate that Sp1 and AP-1 (show JUN Antibodies)-related factors are involved in the regulation of MFG-E8 (show MFGE8 Antibodies) gene transcription by targeting their binding sites in the 5'-flanking region under physiological and inflammatory states.
Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor (show SP3 Antibodies) members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
age-dependent alteration in the Fmr-1 (show FMR1 Antibodies) gene expression is associated with Sp1 interaction with Fmr-1 (show FMR1 Antibodies) promoter which in turn might be related with cognitive development during brain maturation and aging.
The results of this study suggest that SP4 and SP1 upregulation may be part of the mechanisms deregulated downstream of glutamate (show GRIN1 Antibodies) signalling pathways in schizophrenia
The transcription factor SP1 is induced in brain by ischemia/reperfusion.
Data suggest that retinoic acid and GM-CSF (show CSF2 Antibodies)-induced retinal dehydrogenase 2 (RALDH2 (show ALDH1A2 Antibodies)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 via the RA receptor/retinoid X receptor (show RXRB Antibodies) complex to the Aldh1a2 (show ALDH1A1 Antibodies) promoter.
Sp1/Sp3 (show SP3 Antibodies) transcription factors have roles in regulating hallmarks of megakaryocyte maturation and platelet formation and function
Our findings suggest that an SOHLH2 (show SOHLH2 Antibodies)/SOHLH1 (show SOHLH1 Antibodies)/SP1 ternary complex autonomously and cooperatively regulates Sohlh1 (show SOHLH1 Antibodies) gene transcription through juxtaposed E- and GC-boxes during early spermatogenesis and oogenesis.
Results identify Sp1 as an inhibitor of DsbA-L (show GSTK1 Antibodies) gene transcription, and the Sp1-mediated inhibition of DsbA-L (show GSTK1 Antibodies) gene expression may provide a mechanism underlying obesity-induced adiponectin (show ADIPOQ Antibodies) downregulation and insulin (show INS Antibodies) resistance.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1