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SP3 belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. Additionally we are shipping Sp3 Transcription Factor Kits (1) and and many more products for this protein.
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demonstrate that a 186bp region is the minimal essential region and that Sp3-GC1 (show OLFM4 Antibodies) binding is essential to the basal expression of KLF5 (show KLF5 Antibodies)
Sp1 (show PSG1 Antibodies) and Sp3 are not only essential for the basal transcription of the ek1 (show EPHA3 Antibodies) gene, their accessibility to the target site on the ek1 (show EPHA3 Antibodies) promoter is regulated by histone protein modification in a cell line dependent manner.
Human SP1 and SP3 transcription factors regulate MALAT1 expression in hepatocellular carcinoma.
result indicated that promoter binding by Sp1 (show PSG1 Antibodies)/Sp3 was essential, but not a limiting step, for hTERT transcription
Sp3 was found to be a major regulator of BNIP3 (show BNIP3 Antibodies) in prostate cancer.
stimulates CCR7 (show CCR7 Antibodies) expression during the course of dendritic cell maturation
O-GlcNAc modification of Sp3 and Sp4, but not Sp2 transcription factors negatively regulates their transcriptional activities.
characterized two evolutionary highly conserved cis (show CISH Antibodies)-regulatory modules (CRMs) within the proximal promoter each composed of one binding site for the transcription factors SP1 (show PSG1 Antibodies) and SP3 as well as for the nuclear transcription factor Y (show NFYA Antibodies)
These results suggest that XT-1 expression is refractory to the disease process and to inhibition by inflammatory cytokines and that signaling through AP-1, Sp1, and Sp3 is important in the maintenance of XT-1 levels in NP cells.
A novel GC-rich (show RELB Antibodies) element (GRE) spanning -101/-66 sufficient for VEGFR3 (show FLT4 Antibodies) transcription and activated by Sp1 (show PSG1 Antibodies) and Sp3, respectively, was identified.
Our results unveil strikingly different recruitment mechanisms of Sp1 (show SP1 Antibodies)/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
Sp1 (show SP1 Antibodies)/Sp3 transcription factors have roles in regulating hallmarks of megakaryocyte maturation and platelet formation and function
Sp1 (show SP1 Antibodies)/3 transcription factors trigger Mina (show MINA Antibodies) expression through additive activity targeted to a cluster of four Sp1 (show SP1 Antibodies)/3 binding sites forming the P1 promoter.
an interplay between Sp1 (show SP1 Antibodies) and Sp3 as a mechanism involved in the control of Fiat (show TXLNG Antibodies) gene expression in osteoblasts.
Oct-6 (show POU3F1 Antibodies) and Oct-11 (show POU2F3 Antibodies) contribute to the regulation of loricrin (show LOR Antibodies) gene transcription via interaction with AP-1 (show JUN Antibodies) factors and Sp1 (show SP1 Antibodies)/Sp3.
inhibition of FGF-10 (show FGF10 Antibodies) by inflammatory signaling involves the NF-kappaB (show NFKB1 Antibodies)-dependent interactions between RELA (show NFkBP65 Antibodies), SP3, and the Fgf-10 (show FGF10 Antibodies) promoter.
Three GC boxes within the proximal promoter of the murine pyruvate carboxylase (show PC Antibodies) gene bind Sp1 (show SP1 Antibodies)/Sp3
Results suggest that Sp3 and YY1 (show YY1 Antibodies) recruit general transcription factors and facilitate the assembly of a preinitiation complex.
These results establish SUMO conjugation to Sp3 as a molecular beacon (show UBL5 Antibodies) for the assembly of repression machineries to maintain tissue-specific transcriptional gene silencing.
LIF (show LIF Antibodies) and IGF-I (show IGF1 Antibodies), thus, have cooperative and distinct tissue functions during development. Their essential role in bone ossification apparently involves Sp3, and in lung maturation Sp3 together with TTF-1 (show NKX2-1 Antibodies).
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13.
Sp3 transcription factor
, sp3 transcription factor
, transcription factor Sp3
, specificity protein 3
, GC-binding transcription factor Sp3