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SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). Additionally we are shipping SP6 Proteins (4) and SP6 Kits (1) and many more products for this protein.
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Human Polyclonal SP6 Primary Antibody for EIA, WB - ABIN954899
Nakamura, Unda, de-Vega, Vilaxa, Fukumoto, Yamada, Yamada: The Krüppel-like factor epiprofin is expressed by epithelium of developing teeth, hair follicles, and limb buds and promotes cell proliferation. in The Journal of biological chemistry 2003
Show all 2 references for ABIN954899
epiprofin (Epfn, also known as Sp6) plays crucial distinct roles in these transition stages as a cell cycle regulator (show CDKN2A Antibodies) and a transcription factor.
Our data are compatible with Sp6 and Sp8 working together and in a dose-dependent manner as indispensable mediators of Wnt/betacatenin and Bmp signaling in the limb ectoderm
Epfn enhances canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling in the developing dental pulp mesenchyme.
EPFN very likely functions as a modulator of WNT (show WNT2 Antibodies) signaling in the limb ectoderm.
Epiprofin is a highly cell- and tissue-specific nuclear protein expressed primarily by proliferating epithelial cells of teeth, hair follicles, and limbs that may function in the development of these tissues by regulating cell growth
the Sp6 transcript possesses a first exon distinct from the epiprofin one
Epfn has multiple functions for cell fate determination of the dental epithelium by regulating both proliferation and differentiation, preventing continuous tooth budding and generation
Data suggest that Sp6 plays a critical role in the development of several epithelium-containing organs or appendages, possibly by regulating apoptosis.
SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000
Sp6 transcription factor
, transcription factor Sp6-like
, Kruppel-like factor 14
, krueppel-like factor 14
, transcription factor Sp6
, trans-acting transcription factor 6
, specificity protein 6