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SPOCK1 encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. Additionally we are shipping SPOCK1 Antibodies (32) and SPOCK1 Kits (3) and many more products for this protein.
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Human SPOCK1 Protein expressed in Baculovirus infected Insect Cells - ABIN2003172
Edgell, Curiel, Hu, Marr: Efficient gene transfer to human endothelial cells using DNA complexed to adenovirus particles. in BioTechniques 1998
Show all 2 references for ABIN2003172
Human SPOCK1 Protein expressed in HEK-293 Cells - ABIN2181787
Alliel, Perin, Jollès, Bonnet: Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour. in European journal of biochemistry / FEBS 1993
Show all 2 references for ABIN2181787
Knockdown of SPOCK1 inhibits the proliferation.
This study suggests that SPOCK1 promotes proliferation, migration and invasion in glioma cells by activating PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways, which provides a potential theoretical basis for clinical treatment of glioma.
SPOCK1 is highly expressed in ovarian cancer.SPOCK1 contributes to ovarian cancer development and metastasis.
These results suggest that up-regulation of SPOCK1 in ESCC induces EMT (show ITK Proteins), thus promotes migration and invasion in ESCC cells.
Collectively, altered expression of PKP1 (show PKP1 Proteins) and SPOCK1 appears to be a frequent and critical event in prostate cancer
SPOCK1 activates PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling.
Testican-1-induced EMT (show ITK Proteins) signaling.
this study showed that SPOCK1 is a novel metastasis related biomarker in lung cancer and may be new diagnostic and therapeutic target for lung cancer.
In the present study, we showed that SPOCK1 could inhibit apoptosis and promote cancer invasion.
Significant overexpression of osteonectin (show SPARC Proteins) mRNA is associated with pancreatic cancer
results suggest a possibility that testican-1 plays a permissive role for regenerating axons in reactive astrocytes after injury
SPARC (show SPARC Proteins) is counter-adhesive for murine lens epithelial cells. We also identify SPARC (show SPARC Proteins) as a modulator of LN-1 (show PHYH Proteins) secretion and deposition, an activity important in epithelial cell-ECM (show MMRN1 Proteins) interactions in the ocular lens.
Testican-1 is not critical for mouse development [review]
This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition.
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
, sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
, testican 1