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SPOCK1 encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. Additionally we are shipping SPOCK1 Antibodies (32) and SPOCK1 Proteins (8) and many more products for this protein.
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a novel TGF-beta (show TGFB1 ELISA Kits)-induced myoepithelial marker and enhanced invasion in breast cancer cells and correlated with poor prognosis
Our results suggested that microRNA-129-5p could directly specifically suppress SPOCK1, which might be one of the potential mechanisms in inhibiting cell processes including viability, proliferation, cell mitosis, migration, and invasiveness of gastric cancer cells.
SPOCK1 expression is significantly up-regulated in colorectal cancer tissues and associated with tumor size and stage. SPOCK1 stimulates the PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling pathway to inhibit cell apoptosis and promote tumor growth.
findings suggest that SPOCK1 is a critical mediator of tumor growth and metastasis in prostate cancer
Knockdown of SPOCK1 inhibits the proliferation.
This study suggests that SPOCK1 promotes proliferation, migration and invasion in glioma cells by activating PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) and Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathways, which provides a potential theoretical basis for clinical treatment of glioma.
SPOCK1 is highly expressed in ovarian cancer.SPOCK1 contributes to ovarian cancer development and metastasis.
These results suggest that up-regulation of SPOCK1 in ESCC induces EMT (show ITK ELISA Kits), thus promotes migration and invasion in ESCC cells.
Collectively, altered expression of PKP1 (show PKP1 ELISA Kits) and SPOCK1 appears to be a frequent and critical event in prostate cancer
SPOCK1 activates PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling.
results suggest a possibility that testican-1 plays a permissive role for regenerating axons in reactive astrocytes after injury
SPARC (show SPARC ELISA Kits) is counter-adhesive for murine lens epithelial cells. We also identify SPARC (show SPARC ELISA Kits) as a modulator of LN-1 (show PHYH ELISA Kits) secretion and deposition, an activity important in epithelial cell-ECM (show MMRN1 ELISA Kits) interactions in the ocular lens.
Testican-1 is not critical for mouse development [review]
This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition.
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
, sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
, testican 1