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anti-Spastic Paraplegia 11 (Autosomal Recessive) (SPG11) Antibodies

The protein encoded by SPG11 is a potential transmembrane protein that is phosphorylated upon DNA damage. Additionally we are shipping SPG11 Kits (2) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPG11 214585 Q3UHA3
SPG11 80208 Q96JI7
SPG11 311372  
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Top anti-SPG11 Antibodies at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB 50 μg Log in to see 11 to 13 Days
$541.80
Details
Human Mouse Un-conjugated WB Western Blot analysis of SPG11 expression in transfected 293T cell line by SPG11 MaxPab polyclonal antibody.Lane 1: SPG11 transfected lysate(46.75 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of extract of U87 cells, using SPG11 antibody. 100 μL Log in to see 14 Days
$275.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$340.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: SPG11 Antibody [NBP1-82142] - Staining of human rectum shows moderate cytoplasmic and nuclear positivity in glandular cells. 0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: SPG11 Antibody [NBP1-82143] - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules. Immunocytochemistry/Immunofluorescence: SPG11 Antibody [NBP1-82143] Staining of human cell line U-251 MG shows positivity in plasma membrane & cytoplasm. 0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 11 to 16 Days
$499.71
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 6 to 11 Days
$535.71
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Western Blot: SPG11 Antibody [NBP1-76990] - Mouse heart tissue lysate with SPG11 antibody at (A) 0.5 and (B) 1 ug/mL. Immunohistochemistry-Paraffin: SPG11 Antibody [NBP1-76990] - Mouse brain tissue with SPG11 antibody at 2.5 ug/mL. 0.1 mg Log in to see 6 to 9 Days
$447.56
Details

SPG11 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)


Human ,
,

Rat (Rattus)


More Antibodies against SPG11 Interaction Partners

Mouse (Murine) Spastic Paraplegia 11 (Autosomal Recessive) (SPG11) interaction partners

  1. Study provides evidence that SPG11 is implicated in axonal maintenance and cargo trafficking.

Human Spastic Paraplegia 11 (Autosomal Recessive) (SPG11) interaction partners

  1. We identified two novel compound heterozygous mutations in SPG11 in 2 affected individuals with autosomal recessive hereditary spastic paraplegia (ARHSP) with thin corpus callosum

  2. a novel homozygous mutation in the splice site donor of intron 30 (c.5866+1G>A) in consanguineous Japanese SPG11 siblings showing late-onset spastic paraplegia (whole-exome sequencing)

  3. SPG11 is the causative gene of a wide spectrum of clinical features, including autosomal recessive axonal Charcot-Marie-Tooth disease. 1

  4. novel compound heterozygous mutations in SPG11 are associated with HSP and lower motor neuron involvement, mild cerebellar signs and dysgenesis of the corpus callosum

  5. SPG11 mutation has been identified in a Turkish familial hypobetalipoproteinemia family with hereditary spastic paraplegia.

  6. spastizin (show ZFYVE26 Antibodies) and spatacsin were essential components for the initiation of lysosomal tubulation. Together, these results link dysfunction of the autophagy/lysosomal biogenesis machinery to neurodegeneration.

  7. Study provides evidence that SPG11 is implicated in axonal maintenance and cargo trafficking.

  8. A novel homozygous nonsense mutation in exon 15 of the SPG11 gene (c.2678G>A; p.W893X) found in two Spanish siblings with a complicated forms of hereditary spastic paraplegia.

  9. widespread accumulation of spatacsin observed in pathologic alpha-synuclein (show SNCA Antibodies)-containing inclusions suggests that spatacsin may be involved in the pathogenesis of alpha-synucleinopathies

  10. This study identified novel compound heterozygous mutations in the SPG11 gene of the patients as follows: a nonsense mutation c.6856C>T (p.R2286X) in exon 38 and a deletion mutation c.2863delG (p.Glu955Lysfs*8) in exon 16.

SPG11 Antigen Profile

Protein Summary

The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPG11

  • spastic paraplegia 11 (Spg11) antibody
  • spastic paraplegia 11 (autosomal recessive) (SPG11) antibody
  • spastic paraplegia 11 (autosomal recessive) (Spg11) antibody
  • 6030465E24Rik antibody
  • A330015I11 antibody
  • C530005A01Rik antibody
  • KIAA1840 antibody
  • RGD1562529 antibody

Protein level used designations for SPG11

spastic paraplegia 11 protein homolog , spatacsin , colorectal carcinoma-associated protein , spastic paraplegia 11 protein

GENE ID SPECIES
214585 Mus musculus
80208 Homo sapiens
311372 Rattus norvegicus
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