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anti-Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) Antibodies

SPG20 encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. Additionally we are shipping SPG20 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPG20 295053  
SPG20 23111 Q8N0X7
SPG20 229285 Q8R1X6
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Top anti-SPG20 Antibodies at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of Spartin / SPG20 Antibody (C-term) in 293 cell line lysates (35ug/lane).This demonstrates the SPG20 antibody detected the SPG20 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram) using Spartin / SPG20  Antibody (N-term), followed by FITC-conjugated goat-anti-rabbit secondary antibodies. Immunohistochemistry analysis of human brain tissue (Formalin-fixed, Paraffin-embedded) using Spartin / SPG20  Antibody (N-term), followed by peroxidase-conjugated secondary antibody and DAB staining. This data demonstrates the use of this antibody for IHC; clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SPG20 Antibody Titration: 0.2-1 ug/mlPositive Control: OVCAR-3 cell lysate WB Suggested Anti-SPG20  Antibody Titration: 0.2-1 µg/mL  Positive Control: OVCAR-3 cell lysate  SPG20 is supported by BioGPS gene expression data to be expressed in OVCAR3 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of SPG20 Antibody (N-term) (ABIN652983) in NCI-H460 cell line lysates (35 µg/lane). SPG20 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with SPG20 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB SPG20 Antibody (C-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SPG20 antibody detected the SPG20 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IF, WB AP32083PU-N Spartin Antibody (2 µg/ml) staining of methanol-fixed HeLa before (left) and after (right) introduction of siRNA. AP32083PU-N Spartin Antibody staining of HeLa lysate at 2 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Goat Un-conjugated IF, ELISA   0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details

SPG20 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human , ,
,

, , , , ,
Mouse (Murine)


Top referenced anti-SPG20 Antibodies

  1. Human Polyclonal SPG20 Primary Antibody for EIA, WB - ABIN954907 : Tsang, Edwards, Wang, Connell, Davies, Durrington, OKane, Luzio, Reid: The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling. in Human molecular genetics 2009 (PubMed)
    Show all 2 references for ABIN954907

  2. Human Polyclonal SPG20 Primary Antibody for EIA, FACS - ABIN954908 : Milewska, McRedmond, Byrne: Identification of novel spartin-interactors shows spartin is a multifunctional protein. in Journal of neurochemistry 2009 (PubMed)
    Show all 2 references for ABIN954908

More Antibodies against SPG20 Interaction Partners

Human Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) interaction partners

  1. Study identified mutation in SPG20 as the disease causing mutation for Troyer Syndrome in Turkish siblings.

  2. Up-regulation of SPG20 expression, brought about by trisomy 13 in colon cancer cells trisomy 13 amniocytes, is sufficient for the cytokinesis failure phenotype.

  3. Spartin regulates both synaptic development and neuronal survival by controlling microtubule stability via the BMP-Drosophila fragile X mental retardation protein (show FMR1 Antibodies)-Futsch (show MAP1B Antibodies) pathway.

  4. SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2 (show CA2 Antibodies)+ homeostasis

  5. The present study identifies SPG20 promoter hypermethylation as a biomarker suitable for non-invasive detection of colorectal cancer, and a possible mechanism for cytokinesis arrest in colorectal tumorigenesis.

  6. These data suggest that Ist1 (show IST1 Antibodies) interaction is important for spartin recruitment to the midbody and that spartin participates in cytokinesis.

  7. Spartin acts as an adaptor protein that activates and recruits AIP4 (show ITCH Antibodies) E3 ubiquitin ligase (show MUL1 Antibodies) to lipid droplets and by this means regulates the level of ubiquitination of adipophilin (show PLIN2 Antibodies).

  8. SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia.We report mapping of the TRS (show TARS Antibodies) locus to chromosome 13q12.3 and identify a frameshift mutation in SPG20, encoding spartin

  9. Our results suggest that spartin might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome.

  10. This study provides the first evidence of spartin subcellular localization and identifies it as the third mitochondrial protein (show COX6B2 Antibodies) implicated in hereditary spastic paraplegia.

Mouse (Murine) Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) interaction partners

  1. spartin, via the ubiquitin-binding region, binds Lys-63-linked ubiquitin chains but does not bind Lys-48-linked ubiquitin chains. spartin's role in DALIS formation depends on key residues within its ubiquitin-binding region.

  2. alsin (show ALS2 Antibodies) and spartin may interact each other physically

  3. a role for spartin in lipid droplets maintenance and in the regulation of cytokinesis

  4. SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2 (show CA2 Antibodies)+ homeostasis

  5. Our results suggest that spartin might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome.

SPG20 Antigen Profile

Protein Summary

This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).

Gene names and symbols associated with SPG20

  • spastic paraplegia 20 (Troyer syndrome) (Spg20) antibody
  • spastic paraplegia 20 (Troyer syndrome) (SPG20) antibody
  • spastic paraplegia 20, spartin (Troyer syndrome) homolog (human) (Spg20) antibody
  • AI840044 antibody
  • C79168 antibody
  • mKIAA0610 antibody
  • spartin antibody
  • TAHCCP1 antibody

Protein level used designations for SPG20

spartin , spastic paraplegia 20 (Troyer syndrome) homolog , spastic paraplegia 20, spartin (Troyer syndrome) homolog , trans-activated by hepatitis C virus core protein 1

GENE ID SPECIES
295053 Rattus norvegicus
23111 Homo sapiens
534027 Bos taurus
229285 Mus musculus
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