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SPG20 encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. Additionally we are shipping SPG20 Proteins (6) and many more products for this protein.
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Human Polyclonal SPG20 Primary Antibody for EIA, WB - ABIN954907
Tsang, Edwards, Wang, Connell, Davies, Durrington, OKane, Luzio, Reid: The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling. in Human molecular genetics 2009
Show all 2 references for ABIN954907
Human Polyclonal SPG20 Primary Antibody for EIA, FACS - ABIN954908
Milewska, McRedmond, Byrne: Identification of novel spartin-interactors shows spartin is a multifunctional protein. in Journal of neurochemistry 2009
Show all 2 references for ABIN954908
Study identified mutation in SPG20 as the disease causing mutation for Troyer Syndrome in Turkish siblings.
Up-regulation of SPG20 expression, brought about by trisomy 13 in colon cancer cells trisomy 13 amniocytes, is sufficient for the cytokinesis failure phenotype.
Spartin regulates both synaptic development and neuronal survival by controlling microtubule stability via the BMP-Drosophila fragile X mental retardation protein (show FMR1 Antibodies)-Futsch (show MAP1B Antibodies) pathway.
SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2 (show CA2 Antibodies)+ homeostasis
The present study identifies SPG20 promoter hypermethylation as a biomarker suitable for non-invasive detection of colorectal cancer, and a possible mechanism for cytokinesis arrest in colorectal tumorigenesis.
These data suggest that Ist1 (show IST1 Antibodies) interaction is important for spartin recruitment to the midbody and that spartin participates in cytokinesis.
Spartin acts as an adaptor protein that activates and recruits AIP4 (show ITCH Antibodies) E3 ubiquitin ligase (show MUL1 Antibodies) to lipid droplets and by this means regulates the level of ubiquitination of adipophilin (show PLIN2 Antibodies).
SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia.We report mapping of the TRS (show TARS Antibodies) locus to chromosome 13q12.3 and identify a frameshift mutation in SPG20, encoding spartin
Our results suggest that spartin might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome.
This study provides the first evidence of spartin subcellular localization and identifies it as the third mitochondrial protein (show COX6B2 Antibodies) implicated in hereditary spastic paraplegia.
spartin, via the ubiquitin-binding region, binds Lys-63-linked ubiquitin chains but does not bind Lys-48-linked ubiquitin chains. spartin's role in DALIS formation depends on key residues within its ubiquitin-binding region.
alsin (show ALS2 Antibodies) and spartin may interact each other physically
a role for spartin in lipid droplets maintenance and in the regulation of cytokinesis
This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).
, spastic paraplegia 20 (Troyer syndrome) homolog
, spastic paraplegia 20, spartin (Troyer syndrome) homolog
, trans-activated by hepatitis C virus core protein 1