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Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) ELISA Kits

SPG20 encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. Additionally we are shipping SPG20 Antibodies (61) and SPG20 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat SPG20 SPG20 295053  
Anti-Human SPG20 SPG20 23111 Q8N0X7
Anti-Mouse SPG20 SPG20 229285 Q8R1X6
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More ELISA Kits for SPG20 Interaction Partners

Human Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) interaction partners

  1. Study identified mutation in SPG20 as the disease causing mutation for Troyer Syndrome in Turkish siblings.

  2. Up-regulation of SPG20 expression, brought about by trisomy 13 in colon cancer cells trisomy 13 amniocytes, is sufficient for the cytokinesis failure phenotype.

  3. Spartin regulates both synaptic development and neuronal survival by controlling microtubule stability via the BMP-Drosophila fragile X mental retardation protein (show FMR1 ELISA Kits)-Futsch (show MAP1B ELISA Kits) pathway.

  4. SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2 (show CA2 ELISA Kits)+ homeostasis

  5. The present study identifies SPG20 promoter hypermethylation as a biomarker suitable for non-invasive detection of colorectal cancer, and a possible mechanism for cytokinesis arrest in colorectal tumorigenesis.

  6. These data suggest that Ist1 (show IST1 ELISA Kits) interaction is important for spartin recruitment to the midbody and that spartin participates in cytokinesis.

  7. Spartin acts as an adaptor protein that activates and recruits AIP4 (show ITCH ELISA Kits) E3 ubiquitin ligase to lipid droplets and by this means regulates the level of ubiquitination of adipophilin (show PLIN2 ELISA Kits).

  8. SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia.We report mapping of the TRS (show TARS ELISA Kits) locus to chromosome 13q12.3 and identify a frameshift mutation in SPG20, encoding spartin

  9. Our results suggest that spartin might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome.

  10. This study provides the first evidence of spartin subcellular localization and identifies it as the third mitochondrial protein (show COX6B2 ELISA Kits) implicated in hereditary spastic paraplegia.

Mouse (Murine) Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) interaction partners

  1. spartin, via the ubiquitin-binding region, binds Lys-63-linked ubiquitin chains but does not bind Lys-48-linked ubiquitin chains. spartin's role in DALIS formation depends on key residues within its ubiquitin-binding region.

  2. alsin (show ALS2 ELISA Kits) and spartin may interact each other physically

  3. a role for spartin in lipid droplets maintenance and in the regulation of cytokinesis

  4. SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2 (show CA2 ELISA Kits)+ homeostasis

  5. Our results suggest that spartin might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome.

SPG20 Antigen Profile

Antigen Summary

This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).

Gene names and symbols associated with SPG20

  • spastic paraplegia 20 (Troyer syndrome) (Spg20) antibody
  • spastic paraplegia 20 (Troyer syndrome) (SPG20) antibody
  • spastic paraplegia 20, spartin (Troyer syndrome) homolog (human) (Spg20) antibody
  • AI840044 antibody
  • C79168 antibody
  • mKIAA0610 antibody
  • spartin antibody
  • TAHCCP1 antibody

Protein level used designations for SPG20

spartin , spastic paraplegia 20 (Troyer syndrome) homolog , spastic paraplegia 20, spartin (Troyer syndrome) homolog , trans-activated by hepatitis C virus core protein 1

GENE ID SPECIES
295053 Rattus norvegicus
23111 Homo sapiens
534027 Bos taurus
229285 Mus musculus
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