Spastic Paraplegia 21 (SPG21) ELISA Kits

The protein encoded by SPG21 was identified by a two-hybrid screen using CD4 as the bait. Additionally we are shipping SPG21 Antibodies (30) and SPG21 Proteins (18) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SPG21 SPG21 51324 Q9NZD8
Anti-Mouse SPG21 SPG21 27965 Q9CQC8
Anti-Rat SPG21 SPG21 300791 Q5XIC4
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More ELISA Kits for SPG21 Interaction Partners

Human Spastic Paraplegia 21 (SPG21) interaction partners

  1. HBV X gene enhanced SPG21 gene promoter activity, SPG21 mRNA expression and SPG21 protein production in HepG2 cells in a dose-dependent manner.

  2. frameshift results in the premature termination of the encoded product, which is designated "maspardin" (Mast syndrome, spastic paraplegia, autosomal recessive with dementia)

  3. Data report that maspardin localizes prominently to cytoplasm as well as to membranes, possibly at trans-Golgi network/late endosomal compartments, and that maspardin interacts with the aldehyde dehydrogenase ALDH16A1 (show ALDH16A1 ELISA Kits).

Mouse (Murine) Spastic Paraplegia 21 (SPG21) interaction partners

  1. Study showed that the loss of maspardin attenuates the growth, maturation, and axonal branching of cortical neurons to promote progressive neuronal dysfunction; impairment of sensory motor neurons in SPG21-/- mice; and that SPG21-/- cortical neurons failed to respond to EGF (show EGF ELISA Kits)-induced growth and maturation, which is confirmed by the attenuated expression of a subset of EGFR (show EGFR ELISA Kits) target genes

  2. Mast syndrome gene SPG21 in mice has a role in hind limb function and axon branching in cultured cortical neurons

SPG21 Antigen Profile

Antigen Summary

The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with SPG21

  • maspardin pseudogene (LOC100345833) antibody
  • SPG21, maspardin (SPG21) antibody
  • spastic paraplegia 21 (autosomal recessive, Mast syndrome) (SPG21) antibody
  • SPG21, maspardin S homeolog (spg21.S) antibody
  • spastic paraplegia 21 (autosomal recessive, Mast syndrome) (spg21) antibody
  • SPG21, maspardin (Spg21) antibody
  • ACP33 antibody
  • BM-019 antibody
  • C78576 antibody
  • D9Wsu18e antibody
  • GL010 antibody
  • Maspardin antibody
  • MAST antibody
  • wu:fd07h02 antibody
  • zgc:73091 antibody

Protein level used designations for SPG21

spastic paraplegia 21 , acid cluster protein 33 , maspardin , spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog , spastic paraplegia 21 homolog , spastic paraplegia 21, maspardin (autosomal recessive, Mast syndrome)

100345833 Oryctolagus cuniculus
100358285 Oryctolagus cuniculus
51324 Homo sapiens
404069 Bos taurus
415526 Gallus gallus
487599 Canis lupus familiaris
100514084 Sus scrofa
734314 Xenopus laevis
100174603 Pongo abelii
406704 Danio rerio
27965 Mus musculus
300791 Rattus norvegicus
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