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anti-Spastic Paraplegia 7 (SPG7) Antibodies

SPG7 encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Additionally we are shipping SPG7 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPG7 6687 Q9UQ90
SPG7 234847 Q3ULF4
SPG7 353231 Q7TT47
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Top anti-SPG7 Antibodies at antibodies-online.com

Showing 10 out of 71 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in human brain tissue (Formalin-fixed, Paraffin-embedded) using Paraplegin / SPG7  Antibody , followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SPG7 antibody for IHC; Clinical relevance has not been evaluated. Western blot analysis in 293 cell line lysates (35ug/lane) using Paraplegin / SPG7  Antibody . This demonstrates the SPG7 antibody detected the SPG7 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB SPG7 Antibody (Center) (ABIN656408) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IF, WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: 293T 7.5% SDS PAGE antibody diluted at 1:1000 WB Image Sample (50 ug of whole cell lysate) A: Mouse brain 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 6 to 11 Days
$485.71
Details
Human Mouse Un-conjugated IF   100 μL Log in to see 8 to 10 Days
$493.17
Details

SPG7 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-SPG7 Antibodies

  1. Human Polyclonal SPG7 Primary Antibody for EIA, IHC (p) - ABIN953990 : Warnecke, Duning, Schirmacher, Mohammadi, Schwindt, Lohmann, Dziewas, Deppe, Ringelstein, Young: A novel splice site mutation in the SPG7 gene causing widespread fiber damage in homozygous and heterozygous subjects. in Movement disorders : official journal of the Movement Disorder Society 2010 (PubMed)
    Show all 2 references for ABIN953990

More Antibodies against SPG7 Interaction Partners

Human Spastic Paraplegia 7 (SPG7) interaction partners

  1. a novel homozygous frameshift deletion in the SPG7 gene was identifies as the genetic cause of hereditary spastic paraplegia in a Greek family.

  2. this case shows that the spectrum of pathologies in SPG7 can include neuron loss of the dentate nucleus and the inferior olivary nucleus as well as neuritic pathology.

  3. Data indicates that SPG7 is essential for the mitochondrial permeability transition pore (PTP) complex formation, interacts with CypD and VDAC and determines C terminus of SPG7 and CsA-binding region of CypD as necessary for PTP formation.

  4. In unexplained ataxia (show USP14 Antibodies), there was a significant number of patients with SPG7 mutations.

  5. The SPG7 Q866 variant is efficiently processed independent of phosphorylation of AFG3L2 (show AFG3L2 Antibodies) at Y179, which inhibits processing of SPG7.

  6. Using an unbiased exome sequencing approach we identified pathogenic compound heterozygous SPG7 mutations in patients with PEO (show POLG Antibodies) and multiple mitochondrial DNA deletions in skeletal muscle

  7. A Japanese patient is reported with an SPG7 mutation for a slowly progressive form of autosomal recessive cerebellar ataxia (show USP14 Antibodies) and spastic paraplegia.

  8. Data suggest a pathogenic role for this SPG7 p.A510V variant.

  9. SPG7 mutations correlate with spastic paraplegia phenotypes.

  10. SPG7 mutations are a frequent cause of middle-aged onset of spastic gait when strict inclusion criteria are applied and should, therefore, be tested in autosomal recessive or sporadic hereditary spastic paraplegia.

Mouse (Murine) Spastic Paraplegia 7 (SPG7) interaction partners

  1. Studies indicate that both mouse and human SPG7 ESTs containing alternative first exons.

  2. These results provide evidence for different substrate specificities of m-AAA (show AAAS Antibodies) proteases and reveal a striking evolutionary switch of proteases involved in the proteolytic processing of dynamin (show DNM1 Antibodies)-like GTPases in mitochondria.

  3. Data show that Afg3l1 or Afg3l2 are required for maturation of newly imported paraplegin subunits after their cleavage by MPP.

  4. Spg7 and Afg3l2 (show AFG3L2 Antibodies) double mutants show an early-onset ataxic phenotype, indicating a role of the m-AAA (show AAAS Antibodies) proteases in cerebellar degeneration.

SPG7 Antigen Profile

Protein Summary

This gene encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 7.

Gene names and symbols associated with SPG7

  • spastic paraplegia 7 (pure and complicated autosomal recessive) (SPG7) antibody
  • spastic paraplegia 7 homolog (human) (Spg7) antibody
  • AI452278 antibody
  • AU015315 antibody
  • CAR antibody
  • Cmar antibody
  • PGN antibody
  • SPG5C antibody

Protein level used designations for SPG7

paraplegin , spastic paraplegia 7 , spastic paraplegia 7 homolog , spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) , cell adhesion regulator , cell matrix adhesion regulator , spastic paraplegia 7 protein

GENE ID SPECIES
415843 Gallus gallus
6687 Homo sapiens
234847 Mus musculus
353231 Rattus norvegicus
Selected quality suppliers for anti-SPG7 (SPG7) Antibodies
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