Spastic Paraplegia 7 (SPG7) ELISA Kits

SPG7 encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Additionally we are shipping SPG7 Antibodies (75) and SPG7 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SPG7 SPG7 6687 Q9UQ90
Anti-Mouse SPG7 SPG7 234847 Q3ULF4
Anti-Rat SPG7 SPG7 353231 Q7TT47
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More ELISA Kits for SPG7 Interaction Partners

Human Spastic Paraplegia 7 (SPG7) interaction partners

  1. Compound heterozygous variants in SPG7 identified in 22 French Canadian patients with spastic ataxia.

  2. CACNA1A and SPG7 are major ataxia genes.

  3. The results of this study showed that the most frequently detected variant in this cohort was the SPG7 p.Leu78.

  4. A Norwegian founder mutation p.H701P is a major cause of SPG7 in Norway.

  5. a novel homozygous frameshift deletion in the SPG7 gene was identifies as the genetic cause of hereditary spastic paraplegia in a Greek family.

  6. this case shows that the spectrum of pathologies in SPG7 can include neuron loss of the dentate nucleus and the inferior olivary nucleus as well as neuritic pathology.

  7. Data indicates that SPG7 is essential for the mitochondrial permeability transition pore (PTP) complex formation, interacts with CypD and VDAC and determines C terminus of SPG7 and CsA-binding region of CypD as necessary for PTP formation.

  8. In unexplained ataxia, there was a significant number of patients with SPG7 mutations.

  9. The SPG7 Q866 variant is efficiently processed independent of phosphorylation of AFG3L2 (show AFG3L2 ELISA Kits) at Y179, which inhibits processing of SPG7.

  10. Using an unbiased exome sequencing approach we identified pathogenic compound heterozygous SPG7 mutations in patients with PEO (show POLG ELISA Kits) and multiple mitochondrial DNA deletions in skeletal muscle

Mouse (Murine) Spastic Paraplegia 7 (SPG7) interaction partners

  1. Studies indicate that both mouse and human SPG7 ESTs containing alternative first exons.

  2. These results provide evidence for different substrate specificities of m-AAA (show AAAS ELISA Kits) proteases and reveal a striking evolutionary switch of proteases involved in the proteolytic processing of dynamin (show DNM1 ELISA Kits)-like GTPases in mitochondria.

  3. Data show that Afg3l1 or Afg3l2 are required for maturation of newly imported paraplegin subunits after their cleavage by MPP.

  4. Spg7 and Afg3l2 (show AFG3L2 ELISA Kits) double mutants show an early-onset ataxic phenotype, indicating a role of the m-AAA (show AAAS ELISA Kits) proteases in cerebellar degeneration.

SPG7 Antigen Profile

Antigen Summary

This gene encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 7.

Gene names and symbols associated with Spastic Paraplegia 7 (SPG7) ELISA Kits

  • spastic paraplegia 7 (pure and complicated autosomal recessive) (SPG7) antibody
  • spastic paraplegia 7 homolog (human) (Spg7) antibody
  • AI452278 antibody
  • AU015315 antibody
  • CAR antibody
  • Cmar antibody
  • PGN antibody
  • SPG5C antibody

Protein level used designations for Spastic Paraplegia 7 (SPG7) ELISA Kits

paraplegin , spastic paraplegia 7 , spastic paraplegia 7 homolog , spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) , cell adhesion regulator , cell matrix adhesion regulator , spastic paraplegia 7 protein

415843 Gallus gallus
6687 Homo sapiens
234847 Mus musculus
353231 Rattus norvegicus
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