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anti-Speckle-Type POZ Protein (SPOP) Antibodies

SPOP encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. Additionally we are shipping Speckle-Type POZ Protein Kits (37) and Speckle-Type POZ Protein Proteins (13) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPOP 8405 O43791
SPOP 20747 Q6ZWS8
SPOP 287643  
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Top anti-Speckle-Type POZ Protein Antibodies at antibodies-online.com

Showing 10 out of 52 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SPOP Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB SPOP Antibody (N-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the SPOP antibody detected the SPOP protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, WB WB Image Sample (50 ug of whole cell lysate) A: mouse brain 10% SDS PAGE antibody diluted at 1:2000 WB Image Sample (30 ug of whole cell lysate) A: 293T 10% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Chicken Un-conjugated WB 0.05 mg Log in to see 2 to 3 Days
$446.88
Details
Human Chicken Un-conjugated WB 0.05 mg Log in to see 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged SPOP is approximately 0.3ng/ml as a capture antibody. Western Blot detection against Immunogen (33.88 KDa) . 100 μg Log in to see 9 Days
$430.00
Details

SPOP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Speckle-Type POZ Protein Antibodies

  1. Chicken Polyclonal SPOP Primary Antibody for WB - ABIN2784150 : Bunce, Boronenkov, Anderson: Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate. in The Journal of biological chemistry 2008 (PubMed)

More Antibodies against Speckle-Type POZ Protein Interaction Partners

Xenopus laevis Speckle-Type POZ Protein (SPOP) interaction partners

  1. Dzip1 (show DZIP1 Antibodies)-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 Antibodies)/Ci proteins in the Hh pathway.

Human Speckle-Type POZ Protein (SPOP) interaction partners

  1. Data indicate that a mutation in the SPOP gene may not be associated with breast cancer, particularly in Chinese women.

  2. SPOP acts as a tumor suppressor by promoting senescence through degrading SENP7 (show SENP7 Antibodies).

  3. our findings emphasize the critical role of SPOP in the regulation of proliferation and migration in liver cancer

  4. results suggest that SPOP plays a pivotal role in colorectal cancer (CRC (show CALR Antibodies)) through mesenchymal-epithelial transition and matrix metalloproteases.

  5. SPOP functions as a tumor suppressor to negatively regulate the stability of the ERG (show ERG Antibodies) oncoprotein in prostate cancer.

  6. Overcoming ERG (show ERG Antibodies) resistance to SPOP-mediated degradation represents a viable strategy for treatment of prostate cancers expressing either mutated SPOP or truncated ERG (show ERG Antibodies).

  7. Our study revealed novel molecular mechanisms underlying the regulation of ERa protein and provided insights in understanding the relationship between SPOP mutations and the development of endometrial cancer.

  8. SPOP plays critical roles in suppressing gastric tumorigenesis through inhibiting Hh/Gli2 (show GLI2 Antibodies) signaling pathway. It may provide an alternative strategy for developing therapeutic agents of gastric cancer in future.

  9. SPOP mutations and novel variants were detected in 5 of 27 aggressive PCa (show FLVCR1 Antibodies) and one of 22 less aggressive PCa (show FLVCR1 Antibodies)

  10. SPOP has potential use as novel biomarker of glioma and may serve as an independent predictive factor for prognosis of glioma patients.

Mouse (Murine) Speckle-Type POZ Protein (SPOP) interaction partners

  1. These results implicate SPOP as a novel participant in DNA double strand break repair and suggest that SPOP mutation drives prostate tumorigenesis in part through genomic instability.

  2. miR (show MLXIP Antibodies)-145 has a role in post-transcriptional regulation of SPOP expression in selected tissues.

  3. Dzip1 (show DZIP1 Antibodies)-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 Antibodies)/Ci proteins in the Hh pathway.

  4. similar S/T-rich motifs are present in Gli (show GLI1 Antibodies) proteins as well as in numerous HIB-interacting proteins and mediate Gli (show GLI1 Antibodies) degradation by SPOP

  5. MacroH2A1.2 (show H2AFY Antibodies) binds the nuclear protein Spop.

  6. Interaction of endogenous PDX-1 (show PDX1 Antibodies) and PCIF1 in MIN6 insulinoma (show RPS15 Antibodies) cells, is demonstarted.

Speckle-Type POZ Protein (SPOP) Antigen Profile

Protein Summary

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.

Gene names and symbols associated with SPOP

  • speckle-type POZ protein (spop) antibody
  • speckle-type POZ protein (SPOP) antibody
  • Speckle-type POZ protein (Bm1_45730) antibody
  • Speckle-type POZ protein (spop) antibody
  • speckle-type POZ protein (spop-b) antibody
  • speckle-type POZ protein (Spop) antibody
  • AI315626 antibody
  • BTBD32 antibody
  • Pcif1 antibody
  • spop antibody
  • TEF2 antibody
  • zgc:64140 antibody

Protein level used designations for SPOP

speckle-type POZ protein , Speckle-type POZ protein , speckle-type POZ protein-like , HIB homolog 1 , SPOP1 , speckle-type POZ protein B , roadkill homolog 1 , PDX-1 C-terminal-interacting factor 1

GENE ID SPECIES
394599 Xenopus (Silurana) tropicalis
455106 Pan troglodytes
699711 Macaca mulatta
6104034 Brugia malayi
100390371 Callithrix jacchus
100021911 Monodelphis domestica
100056116 Equus caballus
100195374 Salmo salar
100544737 Meleagris gallopavo
100587478 Nomascus leucogenys
100005514 Danio rerio
779391 Xenopus laevis
425528 Gallus gallus
8405 Homo sapiens
480548 Canis lupus familiaris
530618 Bos taurus
20747 Mus musculus
287643 Rattus norvegicus
100343929 Oryctolagus cuniculus
100713182 Cavia porcellus
101111300 Ovis aries
100173908 Pongo abelii
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