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Speckle-Type POZ Protein Proteins (SPOP)

SPOP encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. Additionally we are shipping Speckle-Type POZ Protein Antibodies (53) and Speckle-Type POZ Protein Kits (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPOP 8405 O43791
SPOP 20747 Q6ZWS8
Rat SPOP SPOP 287643  
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Top Speckle-Type POZ Protein Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,026.83
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,026.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,026.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details
HOST_Escherichia coli (E. coli) Human His tag   2 μg Log in to see 6 to 11 Days
$142.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SPOP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced Speckle-Type POZ Protein Proteins

  1. Human SPOP Protein expressed in Escherichia coli (E. coli) - ABIN667901 : Furukawa, He, Borchers, Xiong: Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. in Nature cell biology 2003 (PubMed)
    Show all 2 references for ABIN667901

More Proteins for Speckle-Type POZ Protein (SPOP) Interaction Partners

Xenopus laevis Speckle-Type POZ Protein (SPOP) interaction partners

  1. Dzip1 (show DZIP1 Proteins)-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 Proteins)/Ci proteins in the Hh pathway.

Human Speckle-Type POZ Protein (SPOP) interaction partners

  1. Data indicate that a mutation in the SPOP gene may not be associated with breast cancer, particularly in Chinese women.

  2. SPOP acts as a tumor suppressor by promoting senescence through degrading SENP7 (show SENP7 Proteins).

  3. our findings emphasize the critical role of SPOP in the regulation of proliferation and migration in liver cancer

  4. results suggest that SPOP plays a pivotal role in colorectal cancer (CRC (show CALR Proteins)) through mesenchymal-epithelial transition and matrix metalloproteases.

  5. SPOP functions as a tumor suppressor to negatively regulate the stability of the ERG (show ERG Proteins) oncoprotein in prostate cancer.

  6. Overcoming ERG (show ERG Proteins) resistance to SPOP-mediated degradation represents a viable strategy for treatment of prostate cancers expressing either mutated SPOP or truncated ERG (show ERG Proteins).

  7. Our study revealed novel molecular mechanisms underlying the regulation of ERa protein and provided insights in understanding the relationship between SPOP mutations and the development of endometrial cancer.

  8. SPOP plays critical roles in suppressing gastric tumorigenesis through inhibiting Hh/Gli2 signaling pathway. It may provide an alternative strategy for developing therapeutic agents of gastric cancer in future.

  9. SPOP mutations and novel variants were detected in 5 of 27 aggressive PCa (show FLVCR1 Proteins) and one of 22 less aggressive PCa (show FLVCR1 Proteins)

  10. SPOP has potential use as novel biomarker of glioma and may serve as an independent predictive factor for prognosis of glioma patients.

Mouse (Murine) Speckle-Type POZ Protein (SPOP) interaction partners

  1. These results implicate SPOP as a novel participant in DNA double strand break repair and suggest that SPOP mutation drives prostate tumorigenesis in part through genomic instability.

  2. miR (show MLXIP Proteins)-145 has a role in post-transcriptional regulation of SPOP expression in selected tissues.

  3. Dzip1 (show DZIP1 Proteins)-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 Proteins)/Ci proteins in the Hh pathway.

  4. similar S/T-rich motifs are present in Gli (show GLI1 Proteins) proteins as well as in numerous HIB-interacting proteins and mediate Gli (show GLI1 Proteins) degradation by SPOP

  5. MacroH2A1.2 (show H2AFY Proteins) binds the nuclear protein Spop.

  6. Interaction of endogenous PDX-1 (show PDX1 Proteins) and PCIF1 in MIN6 insulinoma (show RPS15 Proteins) cells, is demonstarted.

Speckle-Type POZ Protein (SPOP) Protein Profile

Protein Summary

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.

Gene names and symbols associated with SPOP

  • speckle-type POZ protein (spop)
  • speckle-type POZ protein (SPOP)
  • Speckle-type POZ protein (Bm1_45730)
  • Speckle-type POZ protein (spop)
  • speckle-type POZ protein (spop-b)
  • speckle-type POZ protein (Spop)
  • AI315626 protein
  • BTBD32 protein
  • Pcif1 protein
  • spop protein
  • TEF2 protein
  • zgc:64140 protein

Protein level used designations for SPOP

speckle-type POZ protein , Speckle-type POZ protein , speckle-type POZ protein-like , HIB homolog 1 , SPOP1 , speckle-type POZ protein B , roadkill homolog 1 , PDX-1 C-terminal-interacting factor 1

GENE ID SPECIES
394599 Xenopus (Silurana) tropicalis
455106 Pan troglodytes
699711 Macaca mulatta
6104034 Brugia malayi
100390371 Callithrix jacchus
100021911 Monodelphis domestica
100056116 Equus caballus
100195374 Salmo salar
100544737 Meleagris gallopavo
100587478 Nomascus leucogenys
100005514 Danio rerio
779391 Xenopus laevis
425528 Gallus gallus
8405 Homo sapiens
480548 Canis lupus familiaris
530618 Bos taurus
20747 Mus musculus
287643 Rattus norvegicus
100343929 Oryctolagus cuniculus
100713182 Cavia porcellus
101111300 Ovis aries
100173908 Pongo abelii
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