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Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. Additionally we are shipping and many more products for this protein.
Showing 10 out of 65 products:
TGF-beta (show TGFB1 Antibodies)/beta2-spectrin/CTCF (show CTCF Antibodies)-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.
Study shows a direct interaction between beta-III spectrin and erythroid ankyrin (show ANK1 Antibodies) in the cerebellum and to demonstrate a critical role for beta-III spectrin in maintaining ankyrin R (show ANK1 Antibodies) throughout the Purkinje cell dendritic tree.
This study demonistrated that beta-III spectrin is critical for development of purkinje cell dendritic tree and spine morphogenesis.
Beta-III spectrin mutation L253P interferes with binding to Arp1 (show APOBEC2 Antibodies) and protein trafficking from the Golgi.
betaIII spectrin disruption impairs synaptogenesis by disturbing the intracellular pathways selectively regulating protein trafficking to the synapse
investigated using either targeted next generation sequencing or trio (show TRIO Antibodies)-based exome sequencing and were found to have mutations in three different genes, KCNC3 (show KCNC3 Antibodies), ITPR1 (show ITPR1 Antibodies) and SPTBN2
First Japanese spinocerebellar ataxia (show USP14 Antibodies) type 5 (SCA5) family with a novel heterozygous three-nucleotide in-frame deletion mutation in the SPTBN2 gene.
A homozygous SPTBN2 nonsense mutation underlying infantile ataxia (show USP14 Antibodies) and psychomotor delay in a human family.
Mutant beta-III spectrin causes mislocalization and dysfunction of mGluR1alpha at dendritic spines.
A novel missense mutation within a SPTBN2 spectrin repeat encoded by exon 12 was found in a family with spinocerebellar ataxia (show USP14 Antibodies) type 5.
the identification of SPARCA1 and normal heterozygous carriers of the stop codon in SPTBN2 provides insights into the mechanism of molecular dominance in SCA5 and demonstrates that the cell-specific repertoire of spectrin subunits
betaIII spectrin regulates the structural integrity and the secretory protein transport of the Golgi complex
two gene markers (CNKSR3 (show CNKSR3 Antibodies) and SPTBN2) differentiate between aspirin-exacerbated respiratory disease and aspirin-tolerant asthma with a perfect discriminative power
This review summarizes data showing that beta-III spectrin mutations are a novel cause of neurodegenerative disease, which may affect the stabilization or trafficking of membrane proteins.
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
, spectrin beta 3
, spectrin beta chain, brain 2
, beta-III spectrin
, glutamate transporter EAAT4-associated protein 41
, spectrin beta chain, non-erythrocytic 2
, spectrin, non-erythroid beta chain 2
, spinocerebellar ataxia 5 protein
, beta SpIII sigma 1
, spectrin-like protein GTRAP41