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anti-Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2) Antibodies

The protein encoded by SYNE2 is a nuclear outer membrane protein that binds cytoplasmic F-actin. Additionally we are shipping SYNE2 Kits (4) and SYNE2 Proteins (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Rat SYNE2 SYNE2 299151  
SYNE2 319565 Q6ZWQ0
SYNE2 23224 Q8WXH0
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Top anti-SYNE2 Antibodies at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IEM, ICC, IF, IP, WB 0.1 mL Log in to see 5 to 6 Days
$455.84
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.89 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged SYNE2 is approximately 0.1ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to SYNE2 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Mouse Rabbit Un-conjugated ICC, IF, IP, WB 0.1 mL Log in to see 5 to 6 Days
$455.84
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p)   25 μL Log in to see 8 to 11 Days
$178.50
Details
Human Mouse Un-conjugated IF, ELISA, WB   100 μg Log in to see 11 to 16 Days
$553.14
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB   100 μg Log in to see 9 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ICC, IF, WB   0.1 mL Log in to see 6 to 9 Days
$452.81
Details
Human Rabbit Un-conjugated   100 μg Log in to see 69 Days
$574.35
Details
Human Rabbit Un-conjugated WB   200 μL Log in to see 9 to 14 Days
$983.48
Details

SYNE2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)


Human ,
,
,

Top referenced anti-SYNE2 Antibodies

  1. Human Monoclonal SYNE2 Primary Antibody for IEM, ICC - ABIN1042628 : Zhen, Libotte, Munck, Noegel, Korenbaum: NUANCE, a giant protein connecting the nucleus and actin cytoskeleton. in Journal of cell science 2002 (PubMed)
    Show all 3 references for ABIN1042628

  2. Human Polyclonal SYNE2 Primary Antibody for ELISA, WB - ABIN565027 : Maddox, Collin, Ikeda, Pratt, Ikeda, Johnson, Hurd, Shopland, Naggert, Chang, Krebs, Nishina: A Mutation in Syne2 Causes Early Retinal Defects in Photoreceptors, Secondary Neurons, and Müller Glia. in Investigative ophthalmology & visual science 2015 (PubMed)

More Antibodies against SYNE2 Interaction Partners

Mouse (Murine) Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2) interaction partners

  1. SYNE2 is important for normal retinal development. We have determined that not only is photoreceptor nuclear migration affected, but also the positions of Muller glia and secondary neurons are disturbed early in retinal development

  2. nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.

  3. Loss of Nesprin 1 (show SYNE1 Antibodies) or 2, or both, led to impairment of gene expression changes in response to biomechanical stimuli. These data suggest a model whereby biomechanical signals are communicated from proteins of the outer nuclear membrane

  4. ectopic expression of BRAP2 (show BRAP Antibodies) inhibits nuclear localization of HMG20A (show HMG20A Antibodies) and NuMA1 (show NUMA1 Antibodies), and prevents nuclear envelope accumulation of SYNE2

  5. Data indicate roles for linkers of nucleus to cytoskeleton (LINC) molecules nesprin2giant and nesprin3, which anchor actin cap fibers to the nucleus.

  6. functions for Nesprin-2 at the nuclear envelope (NE) in gene regulation and in regulation of the actin cytoskeleton which impact on wound healing

  7. Syne-2, SUN1 (show SUN1 Antibodies) and SUN2 (show SUN2 Antibodies) play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development.

  8. The p104 (show RB1 Antibodies) protein interacts with p85alpha and is involved in the regulation of p27(Kip1 (show CDKN1B Antibodies)) expression for the reduction of cellular proliferation.

  9. The Nesprin-2 the conserved C-terminal amino acids PPPX is essential for the interaction with a C-terminal region in Sun1 (show SUN1 Antibodies).

  10. SUN1 (show SUN1 Antibodies) interacts with nuclear lamin A (show LMNA Antibodies) and cytoplasmic nesprins (nesprin-1 (show SYNE1 Antibodies) and nesprin-2)to provide a physical connection between the nuclear lamina and the cytoskeleton.

Human Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2) interaction partners

  1. We show that AMPH-1 (show AMPH Antibodies)/BIN1 (show BIN1 Antibodies) binds to nesprin and actin, as well as to the microtubule-binding protein CLIP170 (show CLIP1 Antibodies) in both species. We propose that BIN1 (show BIN1 Antibodies) has a direct and evolutionarily conserved role in nuclear positioning, altered in myopathies.

  2. nesprin-1 (show SYNE1 Antibodies) and nesprin-2 both regulate nuclear and cytoplasmic architecture.

  3. nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.

  4. Each mutation in LMNA (show LMNA Antibodies) has a distinct impact on the Nersprin-2 interaction that substantially explains how distinct mutations in widely expressed genes lead to the formation of phenotypically different diseases.

  5. High Nesprin-2 expression is associated with colorectal cancer.

  6. ectopic expression of BRAP2 (show BRAP Antibodies) inhibits nuclear localization of HMG20A (show HMG20A Antibodies) and NuMA1 (show NUMA1 Antibodies), and prevents nuclear envelope accumulation of SYNE2.

  7. Multiple novel nesprin-1 (show SYNE1 Antibodies) and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.

  8. Study presents crystal structures of the human SUN2 (show SUN2 Antibodies)-KASH1/2 complex, i.e. SUN2 (show SUN2 Antibodies) complexed with the C-terminal 29 residues of human Nesprin-1 (show SYNE1 Antibodies) or -2 (the core of the LINC complex).

  9. novel isoform, nesprin-2-epsilon, was found to be the major mRNA and protein product of the nesprin-2 gene.

  10. Nesprin-2 interacts with {alpha}-catenin (show CTNNA1 Antibodies) and regulates Wnt (show WNT2 Antibodies) signaling at the nuclear envelope.

SYNE2 Antigen Profile

Protein Summary

The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SYNE2

  • spectrin repeat containing, nuclear envelope 2 (Syne2) antibody
  • spectrin repeat containing, nuclear envelope 2 (SYNE2) antibody
  • spectrin repeat containing, nuclear envelope 2 (syne2) antibody
  • spectrin repeat containing, nuclear envelope 2 (LOC100227700) antibody
  • spectrin repeat containing, nuclear envelope 2 (LOC100346489) antibody
  • 6820443O06Rik antibody
  • AW546258 antibody
  • D12Ertd777e antibody
  • EDMD5 antibody
  • mKIAA1011 antibody
  • Nesp2 antibody
  • Nesp2g antibody
  • Nesprin-2 antibody
  • NUA antibody
  • NUANCE antibody
  • RGD1305248 antibody
  • SYNE-2 antibody
  • SYNE2 antibody
  • TROPH antibody

Protein level used designations for SYNE2

spectrin repeat containing, nuclear envelope 2 , synaptic nuclear envelope 2 , nesprin-2-like , nesprin 2 , nesprin-2 , nuance , nuclear envelope spectrin repeat protein 2 , nucleus and actin connecting element protein , synaptic nuclear envelope protein 2 , nuclear envelope spectrin repeat-2 , polytrophin , synaptic nuclei expressed gene 2

GENE ID SPECIES
299151 Rattus norvegicus
423509 Gallus gallus
490729 Canis lupus familiaris
540504 Bos taurus
746581 Pan troglodytes
100061983 Equus caballus
100216251 Xenopus (Silurana) tropicalis
100227700 Taeniopygia guttata
100346489 Oryctolagus cuniculus
100391491 Callithrix jacchus
100554331 Anolis carolinensis
319565 Mus musculus
23224 Homo sapiens
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