Spen Homolog, Transcriptional Regulator (Drosophila) (SPEN) ELISA Kits

SPEN encodes a hormone inducible transcriptional repressor. Additionally we are shipping SPEN Antibodies (20) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SPEN SPEN 64783 Q96T37
Anti-Mouse SPEN SPEN 56381 Q62504
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More ELISA Kits for SPEN Interaction Partners

Human Spen Homolog, Transcriptional Regulator (Drosophila) (SPEN) interaction partners

  1. The authors demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 (PRMT1 (show PRMT1 ELISA Kits)) at residue R578, leading to its degradation via ubiquitylation by an E3 ligase (CNOT4 (show CNOT4 ELISA Kits)).

  2. SPEN is a novel tumor-suppressor gene that may be clinically useful as a predictive biomarker of tamoxifen response in ERalpha (show ESR1 ELISA Kits)-positive breast cancers.

  3. SPEN mutations were associated with diffuse large B-cell lymphoma with hepatitis C virus infection.

  4. OTT1 regulates the alternative splicing of Mpl (show MPL ELISA Kits)-TR, a truncated isoform of c-Mpl (show MPL ELISA Kits), which modulates Thrombopoietin (show THPO ELISA Kits)-mediated signaling.

  5. Phosphorylation of the CK2 site on SMRT significantly increased affinity for SHARP.

  6. RBM15 does indeed play a critical role in the survival of chronic myelogenous leukemia (CML) cells, which may have potential application in designing molecular therapies for CML treatment.

  7. both Rbm15 and the leukemogenic Rbm15-Mkl1 (show MKL1 ELISA Kits) fusion protein interact with the Setd1b (show SETD1B ELISA Kits) histone H3 (show HIST3H3 ELISA Kits)-Lys4 methyltransferase

  8. These results demonstrate a role for the inactivation of SHARP transcription in DM1 biology.

  9. A four-way variant translocation originating the RBM15-MKL1 (show MKL1 ELISA Kits) fusion gene is associated with acute megakaryoblastic leukemia.

  10. HHV-8 ORF57 interacts with RBM15 and OTT3 (show RBM15B ELISA Kits) to promote expression of viral intronless genes.

Mouse (Murine) Spen Homolog, Transcriptional Regulator (Drosophila) (SPEN) interaction partners

  1. Spenito, a small Spen family member, counteracted Spen function in fat regulation. Finally, mouse Spen and Spenito transcript levels scaled directly with body fat in vivo, suggesting a conserved role in fat liberation and catabolism. This study demonstrates that Spen is a key regulator of energy balance and provides a molecular context to understand the metabolic defects that arise from Spen dysfunction.

  2. Spen is required for gene repression by Xist. Spen is not required for Xist RNA localization and the recruitment of chromatin modifications.

  3. Spen is required for Xist-mediated silencing.

  4. results suggest that Xist silences transcription by directly interacting with SHARP, recruiting SMRT, activating HDAC3, and deacetylating histones to exclude Pol II across the X chromosome

  5. MINT forms a high affinity complex with CSL (show SMPX ELISA Kits); the domains of MINT and CSL (show SMPX ELISA Kits) that are necessary and sufficient for complex formation are delineated

  6. MINT plays an important role in tooth development, in particular, epithelial morphogenesis

  7. Notch1 (show NOTCH1 ELISA Kits) in concert with Notch2 (show NOTCH2 ELISA Kits) contributes to the morphogenesis of renal vesicles into S-shaped bodies in a RBP-J (show RBPJ ELISA Kits)-dependent manner.

  8. Msx2-interacting nuclear target protein (MINT) competed with the intracellular region of Notch (show NOTCH1 ELISA Kits) for binding to a DNA binding protein (show HSF4 ELISA Kits) RBP-J (show RBPJ ELISA Kits) and suppressed the transactivation activity of Notch (show NOTCH1 ELISA Kits) signaling.

  9. Stra13, Dec and Sharp (Mint) bHLH repressors are dynamically regulated during mammary gland development and may function to regulate apoptosis

  10. MINT enhances Runx2 (show RUNX2 ELISA Kits) activation of multiprotein complexes assembled by the OCFRE

SPEN Antigen Profile

Antigen Summary

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator\; this binding can modulate the activity of both liganded and nonliganded steroid receptors.

Gene names and symbols associated with SPEN

  • spen homolog, transcriptional regulator (Drosophila) (SPEN) antibody
  • RNA binding motif protein 15 (RBM15) antibody
  • SPEN homolog, transcriptional regulator (Drosophila) (Spen) antibody
  • HIAA0929 antibody
  • Mint antibody
  • mKIAA0929 antibody
  • OTT antibody
  • OTT1 antibody
  • RBM15C antibody
  • SHARP antibody
  • SPEN antibody

Protein level used designations for SPEN

spen homolog, transcriptional regulator (Drosophila) , SMART/HDAC1 associated repressor protein , RNA-binding motif protein 15 , one twenty two protein , one twenty-two , one-twenty two protein 1 , putative RNA-binding protein 15 , Msx2 interacting nuclear target (MINT) homolog , SMART/HDAC1-associated repressor protein , msx2-interacting protein , nuclear receptor transcription cofactor , Msx2 interacting nuclear target protein

419460 Gallus gallus
64783 Homo sapiens
23013 Homo sapiens
56381 Mus musculus
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