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anti-Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) Antibodies

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Additionally we are shipping SPAM1 Proteins (9) and SPAM1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPAM1 74468  
SPAM1 500052  
SPAM1 6677 P38567
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Top anti-SPAM1 Antibodies at antibodies-online.com

Showing 10 out of 31 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: SPAM1  Sample Tissue: 293T  Antibody Dilution: 1.0 µg/mL Host: Rabbit  Target Name: SPAM1  Sample Tissue: Human Adult Placenta  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.11 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Mouse Rabbit Un-conjugated IHC, WB Immunofluorescence analysis of HeLa cell using SPAM1 antibody. Blue: DAPI for nuclear staining. Western blot analysis of extracts of various cell lines, using SPAM1 antibody. 200 μL Log in to see 9 Days
$588.50
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$522.50
Details
Human Rabbit Un-conjugated IHC   100 μL Log in to see 8 to 10 Days
$581.17
Details
Human Rabbit Un-conjugated IF   50 μL Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details

SPAM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


Rat (Rattus)


Human , , ,
,

, , , , ,

Top referenced anti-SPAM1 Antibodies

  1. Human Polyclonal SPAM1 Primary Antibody for ELISA, WB - ABIN562973 : Monzón, Manzanares, Schmid, Casalino-Matsuda, Forteza: Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells. in American journal of respiratory cell and molecular biology 2008 (PubMed)
    Show all 5 references for ABIN562973

More Antibodies against SPAM1 Interaction Partners

Mouse (Murine) Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) interaction partners

  1. PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination.

  2. ACR (show ACR Antibodies) or PRSS21 (show PRSS21 Antibodies) or both may function cooperatively with SPAM1 in sperm/cumulus penetration

  3. The data from this paper suggests that the hyaluronan-degrading activity of the sperm hyaluronidase (show HAase Antibodies) HYAL5 may not be required for fertilization, at least in the mouse.

  4. Entrapment of spontaneous Spam1 mutations, owing to recombination suppression near the Robertsonion translocation junctions, is proposed as the major underlying defect of the sperm dysfunction.

  5. sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg

  6. Epididymal Spam1 is secreted predominantly as insoluble particles. Majority of epididymal Spam1 is released with its lipid anchor, a form in which it can bind to sperm.

  7. Spam1 is a multifunctional protein and that it is less restricted in its expression than previously reported

  8. Sperm adhesion molecule 1 (SPAM1) is distributed in the nonciliated epithelial cells. Efferent ducts have the most intense staining. Spam1 was also present in the accessory organs, the prostate, and seminal vesicles and its fluid.

  9. Testicular compartmentalization of Spam1 RNA provides strong support for the lack of sharing hypothesis, and represents a possible mechanism of Spam1-associated transmission ratio distortion .

  10. Mouse SPAM1 and HYAL5 but not HYALP1 (show HYAL4 Antibodies) proteins exhibit hyaluronidase (show HAase Antibodies) activity at neutral pH.

Human Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) interaction partners

  1. HSPA2 (show HSPA2 Antibodies) regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition, such as arylsulfatase A (show ARSA Antibodies) and SPAM1.

  2. The interaction between SPAM1, ARSA (show ARSA Antibodies) and HSPA2 (show HSPA2 Antibodies) in a multimeric complex mediating sperm-egg interaction.

  3. PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination.

  4. SPAM1 mRNA & protein occur in all 3 regions of epididymis & vas (show AVP Antibodies) deferens. It has hyaluronidase (show HAase Antibodies) activity at pH 7.0. The proximal promoter has epididymal transcription factor sites including androgen receptor (show AR Antibodies) elements. Its role may be in sperm maturation.

SPAM1 Antigen Profile

Protein Summary

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1\; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPAM1

  • hyaluronoglucosaminidase 5 (Hyal5) antibody
  • sperm adhesion molecule 1 (Spam1) antibody
  • sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1) antibody
  • sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (Spam1) antibody
  • 4933439A12Rik antibody
  • AV039194 antibody
  • HYA1 antibody
  • HYAL1 antibody
  • HYAL3 antibody
  • HYAL5 antibody
  • PH-20 antibody
  • PH20 antibody
  • SPAG15 antibody
  • Spam antibody

Protein level used designations for SPAM1

hyaluronidase Hyal-5 , hyaluronidase PH-20 , hyal-PH20 , hyaluronoglucosaminidase PH-20 , sperm surface protein PH-20 , sperm protein PH-20 , sperm surface antigen 2B1 , PH-20 protein

GENE ID SPECIES
74468 Mus musculus
500052 Rattus norvegicus
20690 Mus musculus
100135624 Cavia porcellus
6677 Homo sapiens
117037 Rattus norvegicus
100009391 Oryctolagus cuniculus
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