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Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) ELISA Kits

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Additionally we are shipping SPAM1 Antibodies (31) and SPAM1 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SPAM1 74468  
SPAM1 500052  
SPAM1 6677 P38567
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Top SPAM1 ELISA Kits at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 3.9pg/ml 15.6-1000 pg/mL 96 Tests Log in to see 11 to 13 Days
$910.56
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Rat
96 Tests Log in to see 11 to 13 Days
$875.60
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Mouse
96 Tests Log in to see 11 to 13 Days
$875.60
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More ELISA Kits for SPAM1 Interaction Partners

Mouse (Murine) Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) interaction partners

  1. PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination.

  2. ACR (show ACR ELISA Kits) or PRSS21 (show PRSS21 ELISA Kits) or both may function cooperatively with SPAM1 in sperm/cumulus penetration

  3. The data from this paper suggests that the hyaluronan-degrading activity of the sperm hyaluronidase (show HAase ELISA Kits) SPAM1 may not be required for fertilization, at least in the mouse.

  4. Mouse SPAM1 and HYAL5 but not HYALP1 (show HYAL4 ELISA Kits) proteins exhibit hyaluronidase (show HAase ELISA Kits) activity at neutral pH.

  5. SPAM1 may function in sperm entry into the cumulus and sperm penetration through the cumulus matrix.

  6. Entrapment of spontaneous Spam1 mutations, owing to recombination suppression near the Robertsonion translocation junctions, is proposed as the major underlying defect of the sperm dysfunction.

  7. sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg

  8. Epididymal Spam1 is secreted predominantly as insoluble particles. Majority of epididymal Spam1 is released with its lipid anchor, a form in which it can bind to sperm.

  9. Spam1 is a multifunctional protein and that it is less restricted in its expression than previously reported

  10. Sperm adhesion molecule 1 (SPAM1) is distributed in the nonciliated epithelial cells. Efferent ducts have the most intense staining. Spam1 was also present in the accessory organs, the prostate, and seminal vesicles and its fluid.

Human Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) interaction partners

  1. HSPA2 (show HSPA2 ELISA Kits) regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition, such as arylsulfatase A (show ARSA ELISA Kits) and SPAM1.

  2. The interaction between SPAM1, ARSA (show ARSA ELISA Kits) and HSPA2 (show HSPA2 ELISA Kits) in a multimeric complex mediating sperm-egg interaction.

  3. PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination.

  4. SPAM1 mRNA & protein occur in all 3 regions of epididymis & vas (show AVP ELISA Kits) deferens. It has hyaluronidase (show HAase ELISA Kits) activity at pH 7.0. The proximal promoter has epididymal transcription factor sites including androgen receptor (show AR ELISA Kits) elements. Its role may be in sperm maturation.

SPAM1 Antigen Profile

Antigen Summary

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1\; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPAM1

  • hyaluronoglucosaminidase 5 (Hyal5) antibody
  • sperm adhesion molecule 1 (Spam1) antibody
  • sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1) antibody
  • sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (Spam1) antibody
  • 4933439A12Rik antibody
  • AV039194 antibody
  • HYA1 antibody
  • HYAL1 antibody
  • HYAL3 antibody
  • HYAL5 antibody
  • PH-20 antibody
  • PH20 antibody
  • SPAG15 antibody
  • Spam antibody

Protein level used designations for SPAM1

hyaluronidase Hyal-5 , hyaluronidase PH-20 , hyal-PH20 , hyaluronoglucosaminidase PH-20 , sperm surface protein PH-20 , sperm protein PH-20 , sperm surface antigen 2B1 , PH-20 protein

GENE ID SPECIES
74468 Mus musculus
500052 Rattus norvegicus
20690 Mus musculus
100135624 Cavia porcellus
6677 Homo sapiens
117037 Rattus norvegicus
100009391 Oryctolagus cuniculus
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