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Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Additionally we are shipping SPAM1 Antibodies (31) and SPAM1 Kits (3) and many more products for this protein.
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Human SPAM1 Protein expressed in HEK-293 Cells - ABIN2181785
Lin, Kimmel, Myles, Primakoff: Molecular cloning of the human and monkey sperm surface protein PH-20. in Proceedings of the National Academy of Sciences of the United States of America 1993
Show all 3 references for ABIN2181785
PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination.
ACR (show ACR Proteins) or PRSS21 (show PRSS21 Proteins) or both may function cooperatively with SPAM1 in sperm/cumulus penetration
The data from this paper suggests that the hyaluronan-degrading activity of the sperm hyaluronidase (show HAase Proteins) HYAL5 may not be required for fertilization, at least in the mouse.
Entrapment of spontaneous Spam1 mutations, owing to recombination suppression near the Robertsonion translocation junctions, is proposed as the major underlying defect of the sperm dysfunction.
sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg
Epididymal Spam1 is secreted predominantly as insoluble particles. Majority of epididymal Spam1 is released with its lipid anchor, a form in which it can bind to sperm.
Spam1 is a multifunctional protein and that it is less restricted in its expression than previously reported
Sperm adhesion molecule 1 (SPAM1) is distributed in the nonciliated epithelial cells. Efferent ducts have the most intense staining. Spam1 was also present in the accessory organs, the prostate, and seminal vesicles and its fluid.
Testicular compartmentalization of Spam1 RNA provides strong support for the lack of sharing hypothesis, and represents a possible mechanism of Spam1-associated transmission ratio distortion .
Mouse SPAM1 and HYAL5 but not HYALP1 (show HYAL4 Proteins) proteins exhibit hyaluronidase (show HAase Proteins) activity at neutral pH.
Human posterior head 20 (hPH20) and homo sapiens sperm acrosome associated 1 (show SPACA1 Proteins) (hSPACA1) immunocontraceptive epitopes reduced fertility in male/female mice.
HSPA2 (show HSPA2 Proteins) regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition, such as arylsulfatase A (show ARSA Proteins) and SPAM1.
The interaction between SPAM1, ARSA (show ARSA Proteins) and HSPA2 (show HSPA2 Proteins) in a multimeric complex mediating sperm-egg interaction.
SPAM1 mRNA & protein occur in all 3 regions of epididymis & vas (show AVP Proteins) deferens. It has hyaluronidase (show HAase Proteins) activity at pH 7.0. The proximal promoter has epididymal transcription factor sites including androgen receptor (show AR Proteins) elements. Its role may be in sperm maturation.
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1\; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
, hyaluronidase PH-20
, hyaluronoglucosaminidase PH-20
, sperm surface protein PH-20
, sperm protein PH-20
, sperm surface antigen 2B1
, PH-20 protein