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The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Additionally we are shipping Sperm Associated Antigen 1 Antibodies (49) and Sperm Associated Antigen 1 Kits (4) and many more products for this protein.
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SPAG1 probably plays a role in the cytoplasmic assembly.
The h-Sp-1 molecule is expressed in sperm and testes and plays a role in fertilization.
HSD-3.8 (SPAG1), interacts with G-protein beta 1 subunit (show GNB1 Proteins) and activates extracellular signal-regulated kinases 1 and 2
Immunocytochemical analysis demonstrated colocalization of SPAG1 with microtubules, and their association was confirmed by co-immunoprecipitation; subsequent motility assays further substantiated a potential role of SPAG1 in cancer cell motility
The number of PCR positives of sperm mtDNA in two-cell embryos was significantly increased following sperm incubation with anti-tetratricopeptide repeat-containing protein involved in spermatogenesis (tpis).
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.
sperm associated antigen 1
, sperm-associated antigen 1
, TPR-containing protein involved in spermatogenesis
, infertility-related sperm protein Spag-1
, tetratricopeptide repeat-containing protein