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SPA17 encodes a protein present at the cell surface. Additionally we are shipping SPA17 Antibodies (57) and SPA17 Kits (21) and many more products for this protein.
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Sp17 and ASP (show ASIP Proteins) cancer/testis antigens were found in ciliated cells of four ciliated hepatic foregut cysts (CHFCs). Further characterization of Sp17 and ASP (show ASIP Proteins) in patients with CHFCs may provide significant clues for understanding the molecular mechanisms underlying their predisposition to develop squamous cell carcinomas.
dendritic cells from human umbilical cord blood modulated for SP17 expression induced antigen-specific anti-tumor immunity against SP17(+) non-small cell lung cancer.
SP17/AKAP4 (show AKAP4 Proteins)/PTTG1 (show PTTG1 Proteins) are expressed in both human NSCLC cell lines and primary tumors and can elicit an immunogenic response in lung cancer patients.
NY-ESO-1 (show CTAG1B Proteins) and SP17 was not significantly associated with a specific histotype, but high-level GAGE expression was more frequent in squamous cell carcinoma. GAGE expression was demonstrated to be significantly higher in stage II-IIIa than stage I NSCLC.
Sp17 is highly expressed in hepatocellular carcinoma cells
SP17 was expressed in many cancer types with an overall frequency of 12%. SP17 was most frequently expressed in a different set of cancer types than MAGE (show MAGEB10 Proteins)-A and GAGE antigens and rarely overlapped with these proteins.
Sperm protein 17 is highly expressed in endometrial and cervical cancers.
Data show that cisplatin induced decrease in Sp17 levels was due to transcriptional inhibition and cisplatin-resistant cell lines did not show this decrease in Sp17 levels in response to cisplatin treatment.
Sp17 has different expression patterns in cancer cell lines as compared to normal non-testes tissues and a potential pathogenic role in diseased cells
expression of Sp17, a thought to be gamete-specific protein, in the synoviocytes of 8/8 female rheumatoid arthritis patients
mRBMY protein can bind to the testis and sperm-specific spa17 mRNA.
Spa17 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.
sperm autoantigenic protein 17
, sperm protein 17
, sperm surface protein Sp17
, cancer/testis antigen 22
, band 34