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Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Additionally we are shipping Spermatogenesis Associated 13 Antibodies (16) and many more products for this protein.
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Phosphorylation of S106 modulates Asef2 guanine nucleotide exchange factor (show RASGRF1 Proteins) activity and Asef2-mediated cell migration and adhesion turnover.
A new role for Rac (show AKT1 Proteins) activation, promoted by Asef2, in modulating actomyosin contractility.
Asef2 activates Rac1 to modulate adhesion and actin dynamics and thereby regulate cell migration.
These results suggest that similar to Asef (show ARHGEF4 Proteins), Asef2 plays an important role in cell migration, and that Asef2 activated by truncated mutant APC (show APC Proteins) is required for aberrant migration of colorectal tumor cells.
Asef2, Neurabin2 and APC (show APC Proteins) cooperatively regulate actin cytoskeletal organization and are required for HGF (show HGF Proteins)-induced cell migration.
Asef (show ARHGEF4 Proteins) and Asef2 are required for adenoma formation in Apc (show APC Proteins)(Min/+)mice. [Asef2, mouse]
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
APC-stimulated guanine nucleotide exchange factor 2
, adenomatous polyposis coli stimulated exchange factor 2
, spermatogenesis-associated protein 13