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Spermatogenesis Associated 13 Proteins (SPATA13)

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Additionally we are shipping Spermatogenesis Associated 13 Antibodies (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPATA13 221178 Q96N96
SPATA13 219140 Q5DU57
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Top Spermatogenesis Associated 13 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details

SPATA13 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Spermatogenesis Associated 13 (SPATA13) Interaction Partners

Human Spermatogenesis Associated 13 (SPATA13) interaction partners

  1. Phosphorylation of S106 modulates Asef2 guanine nucleotide exchange factor (show RASGRF1 Proteins) activity and Asef2-mediated cell migration and adhesion turnover.

  2. A new role for Rac (show AKT1 Proteins) activation, promoted by Asef2, in modulating actomyosin contractility.

  3. Asef2 activates Rac1 to modulate adhesion and actin dynamics and thereby regulate cell migration.

  4. These results suggest that similar to Asef (show ARHGEF4 Proteins), Asef2 plays an important role in cell migration, and that Asef2 activated by truncated mutant APC (show APC Proteins) is required for aberrant migration of colorectal tumor cells.

  5. Asef2, Neurabin2 and APC (show APC Proteins) cooperatively regulate actin cytoskeletal organization and are required for HGF (show HGF Proteins)-induced cell migration.

Mouse (Murine) Spermatogenesis Associated 13 (SPATA13) interaction partners

  1. Asef (show ARHGEF4 Proteins) and Asef2 are required for adenoma formation in Apc (show APC Proteins)(Min/+)mice. [Asef2, mouse]

Spermatogenesis Associated 13 (SPATA13) Protein Profile

Protein Summary

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Gene names and symbols associated with SPATA13

  • spermatogenesis associated 13 (SPATA13)
  • spermatogenesis associated 13 (Spata13)
  • ARHGEF29 protein
  • ASEF2 protein
  • C79050 protein
  • ESTM11 protein
  • mFLJ00298 protein
  • X83327 protein

Protein level used designations for SPATA13

APC-stimulated guanine nucleotide exchange factor 2 , adenomatous polyposis coli stimulated exchange factor 2 , spermatogenesis-associated protein 13 , asef2

GENE ID SPECIES
221178 Homo sapiens
219140 Mus musculus
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