Spermatogenesis and Oogenesis Specific Basic Helix-Loop-Helix 2 Proteins (SOHLH2)

Probable transcription factor, which may be involved in spermatogenesis and oogenesis (By similarity).. Additionally we are shipping SOHLH2 Antibodies (52) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SOHLH2 54937 Q9NX45
SOHLH2 74434 Q9D489
SOHLH2 619575 Q3MHT3
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Top SOHLH2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,300.00
Details

SOHLH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Spermatogenesis and Oogenesis Specific Basic Helix-Loop-Helix 2 (SOHLH2) Interaction Partners

Human Spermatogenesis and Oogenesis Specific Basic Helix-Loop-Helix 2 (SOHLH2) interaction partners

  1. Results identified MMP9 (show MMP9 Proteins) as a novel target for transcriptional inactivation by Sohlh2 and demonstrated that the Sohlh2 downregulation of MMP9 (show MMP9 Proteins) is critical for inhibiting human ovarian cancer cell invasion.

  2. The polymorphisms rs1328626 and rs6563386 of the SOHLH2 gene would be the genetic risk factors for nonobstructive azoospermia in the Chinese population. The SNP rs1328641 might influence testes development in the NOA (show DLAT Proteins) patients.

  3. Low Sohlh2 expression is associated with ovarian cancer.

  4. Our identification of novel variants in the SOHLH2 gene, in women with POF (show POF1B Proteins) of both Chinese and Serbian origin, strongly suggests an important role for SOHLH2 in human POF (show POF1B Proteins) etiology.

Mouse (Murine) Spermatogenesis and Oogenesis Specific Basic Helix-Loop-Helix 2 (SOHLH2) interaction partners

  1. Sohlh1 (show SOHLH1 Proteins) and Sohlh2 are essential regulators of oocyte differentiation but do not affect meiosis I.

  2. SOHLH2 is critical for the formation of synaptonemal complexes.

  3. Sohlh2 may inhibit oocyte apoptosis via c-kit/PI3K/Akt (show AKT1 Proteins)/Foxo3a (show FOXO3 Proteins) signalling pathway

  4. SOHLH1 and SOHLH2 were able to directly and cooperatively repress STRA8 expression in cell lines in vitro through binding to its promoter.

  5. Our findings suggest that an SOHLH2/SOHLH1 (show SOHLH1 Proteins)/SP1 (show SP1 Proteins) ternary complex autonomously and cooperatively regulates Sohlh1 (show SOHLH1 Proteins) gene transcription through juxtaposed E- and GC-boxes during early spermatogenesis and oogenesis.

  6. Effects of BMP4 on mouse primordial follicle growth were assayed by follicle count and TUNEL labeling. The expression of phospho-SMAD1/5/8, Sohlh2, and c-kit were measured by immunohistochemistry, RT-PCR, and Western blotting.

  7. SOHLH1 (show SOHLH1 Proteins) and SOHLH2 directly stimulate Kit transcription in postnatal spermatogonia, thus activating the signaling involved in spermatogonia differentiation and spermatogenetic progression.

  8. Data suggest that a dynamic DNA CpG methylation in Sohlh2 and Figlalpha promoters, but not in the intron and exon sequences, is linked to regulation of gene expression, even though CpG islands are also present in their introns or exons.

  9. SOHLH1 (show SOHLH1 Proteins) and SOHLH2 suppress genes involved in spermatogonial stem cell maintenance, and induce genes important for spermatogonial differentiation.

  10. The expression pattern of SOHLH2 suggests that it may be a critical regulator of early germ cell development.

SOHLH2 Protein Profile

Protein Summary

Probable transcription factor, which may be involved in spermatogenesis and oogenesis (By similarity).

Gene names and symbols associated with SOHLH2

  • spermatogenesis and oogenesis specific basic helix-loop-helix 2 (SOHLH2)
  • spermatogenesis and oogenesis specific basic helix-loop-helix 2 (Sohlh2)
  • 4933406N12Rik protein
  • AI413378 protein
  • bHLHe81 protein
  • RGD1304752 protein
  • SPATA28 protein
  • TEB1 protein

Protein level used designations for SOHLH2

spermatogenesis and oogenesis specific basic helix-loop-helix 2 , spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2-like , spermatogenesis associated 28 , spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2

GENE ID SPECIES
452536 Pan troglodytes
486009 Canis lupus familiaris
518810 Bos taurus
693608 Macaca mulatta
100443062 Pongo abelii
100580067 Nomascus leucogenys
54937 Homo sapiens
74434 Mus musculus
619575 Rattus norvegicus
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