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Spermidine/spermine N1-Acetyltransferase 1 Proteins (SAT1)

The protein encoded by SAT1 belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. Additionally we are shipping SAT1 Antibodies (46) and SAT1 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SAT1 20229 P48026
Rat SAT1 SAT1 302642  
SAT1 6303 P21673
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Top SAT1 Proteins at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag Spermidine/spermine N1-Acetyltransferase 1 (SAT1) (AA 5-171) protein (GST tag) 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,396.17
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,396.17
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,396.17
Details
Yeast Cricetulus griseus His tag   1 mg Log in to see 56 to 66 Days
$2,396.17
Details

SAT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

Top referenced SAT1 Proteins

  1. Human SAT1 Protein expressed in Escherichia coli (E. coli) - ABIN1046916 : Casero, Celano, Ervin, Applegren, Wiest, Pegg: Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase. in The Journal of biological chemistry 1991 (PubMed)
    Show all 3 references for ABIN1046916

  2. Human SAT1 Protein expressed in Escherichia coli (E. coli) - ABIN667745 : Niiranen, Keinänen, Pirinen, Heikkinen, Tusa, Fatrai, Suppola, Pietilä, Uimari, Laakso, Alhonen, Jänne: Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging. in Journal of cellular and molecular medicine 2006 (PubMed)
    Show all 2 references for ABIN667745

  3. Human SAT1 Protein expressed in Wheat germ - ABIN1319174 : Sun, Liu, Yang, Xu, Yan, Wang, Liu: Adenovirus-mediated expression of SSAT inhibits colorectal cancer cell growth in vitro. in Acta pharmacologica Sinica 2008 (PubMed)

More Proteins for Spermidine/spermine N1-Acetyltransferase 1 (SAT1) Interaction Partners

Mouse (Murine) Spermidine/spermine N1-Acetyltransferase 1 (SAT1) interaction partners

  1. the level of SSAT enzyme activity affected osteoblastogenesis and hence influenced bone remodeling and the bone phenotype in mice

  2. Enhanced SSAT expression by proximal tubule epithelial cells leads to tubular damage, and its deficiency reduces the severity of renal I/R injury through reduction of cellular damage and modulation of the innate immune response

  3. The SSAT overexpression and the concomitantly accelerated polyamine metabolism in hematopoietic cells and bone marrow microenvironment affect lineage commitment and lead to the development of a mouse myeloproliferative disease in SSAT mice.

  4. the results indicate that transcriptional modulation of the SAT1 gene is not a significant component of the hyperoxaluria observed in these rat models

  5. study suggests that SSAT overexpression obtained in SSAT mice enhances the anti-inflammatory actions in the acute phase of LPS (show TLR4 Proteins)-induced immune response

  6. Expression of SSAT increases in kidneys subjected to endotoxic acute kidney injury and that increased polyamine back conversion and oxidation contribute to tubular damage in endotoxin-induced AKI.

  7. increased SSAT expression solely accompanies the proliferative response of mouse kidney, and suggest the importance of post-transcriptional regulation to the control of SSAT activity

  8. Testosterone treatment enhanced AZ1 and N1-SSAT mRNA levels in a time-dependent manner

  9. antiproliferative and metabolic consequences of SSAT overexpression in a prostate cancer model

  10. cutaneous changes of SSAT transgenic animals are due to disorders of the keratinocyte differentiation.

Human Spermidine/spermine N1-Acetyltransferase 1 (SAT1) interaction partners

  1. Results show low SAT1 brain expression in depressed suicides and implicate low SAT1 brain expression in major depression independent of suicide

  2. Data suggest that SAT1 plays role in apoptosis; overexpression of SAT1 in human embryonic kidney cell line leads to a rapid depletion of spermidine and spermine, arrest in cell growth, and mitochondria-mediated apoptosis.

  3. Analysis shows a significant direct correlation between SSAT expression in Prostatic Cancer tissues and disease progression.

  4. Enhanced SSAT expression by proximal tubule epithelial cells leads to tubular damage, and its deficiency reduces the severity of renal I/R injury through reduction of cellular damage and modulation of the innate immune response

  5. A role for SAT1 in homologous recombination.

  6. The Catabolic enzyme SSAT expression levels was up-regulated in both cell lines; however, the specific SSAT siRNA treatments prevented the EBR-induced apoptosis only in LNCaP (AR+) cells.

  7. study postulates a mechanism for SAT1 and SMOX (show SMOX Proteins) down-regulation by post-transcriptional activity of miRNAs.

  8. SAT1 transcription is influenced by lithium and this effect is altered in bipolar disease patients who completed suicide.

  9. berberine inhibits cellular growth by affecting polyamine metabolism, in particular through the upregulation of the key catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT).

  10. EBV-positive Akata cells demonstrated decreased SAT1 enzyme activity concomitant with altered intracellular polyamine level.

SAT1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.

Gene names and symbols associated with SAT1

  • spermidine/spermine N1-acetyltransferase 1 (SAT1)
  • spermidine/spermine N1-acetyltransferase 1 (sat1)
  • spermidine/spermine N1-acetyl transferase 1 (Sat1)
  • spermidine/spermine N1-acetyltransferase (LOC100689427)
  • spermidine/spermine N1-acetyltransferase 1 (sat1-b)
  • AA617398 protein
  • Ab2-402 protein
  • DC21 protein
  • KFSD protein
  • KFSDX protein
  • Sat protein
  • sat1 protein
  • sat1b protein
  • SSAT protein
  • SSAT-1 protein

Protein level used designations for SAT1

spermidine/spermine N1-acetyltransferase 1 , diamine N-acetyltransferase 1 , SSAT-1 , diamine acetyltransferase 1 , polyamine N-acetyltransferase 1 , putrescine acetyltransferase , spermidine/spermine N(1)-acetyltransferase 1 , Spermidine / spermine N1-acyltransferase (diamine acetyltransferase) , Polyamine N-acetyltransferase 1 , Putrescine acetyltransferase , Spermidine/spermine N(1)-acetyltransferase 1 , diamine N-acetyltransferase 1 b , spermidine/spermine N1-acetyltransferase 1 b , SSAT , spermidine/spermine N1-acetyltransferase alpha , spermidine/spermine N-acetyltransferase

GENE ID SPECIES
465538 Pan troglodytes
480865 Canis lupus familiaris
493359 Xenopus (Silurana) tropicalis
20229 Mus musculus
302642 Rattus norvegicus
100689427 Cricetulus griseus
447322 Xenopus laevis
374006 Gallus gallus
6303 Homo sapiens
397645 Sus scrofa
508861 Bos taurus
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