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anti-Sphingomyelin Synthase 2 (SGMS2) Antibodies

Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. Additionally we are shipping Sphingomyelin Synthase 2 Proteins (5) and Sphingomyelin Synthase 2 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SGMS2 166929 Q8NHU3
SGMS2 74442 Q9D4B1
SGMS2 310849 Q4JM44
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Top anti-Sphingomyelin Synthase 2 Antibodies at antibodies-online.com

Showing 10 out of 58 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SGMS2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SGMS2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: 293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SGMS2 (arrow) using SGMS2 Antibody (C-term) Cat.-No AP53889PU-N. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SGMS2 gene. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow Cytometric analysis of MCF-7 cells using SGMS2 Antibody (C-term) Cat.-No AP53890PU-N (Right histogram) compared to a negative control cell (Left histogram). FITC-conjugated Goat-anti-Rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human brain tissue stained with SGMS2 Antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SGMS2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 10 blots Log in to see 6 to 8 Days
$533.50
Details
Human Rabbit Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$533.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB SGMS2 Antibody (C-term) (ABIN653758) western blot analysis in MCF-7,CEM,Hela cell line lysates (35 µg/lane).This demonstrates the SGMS2 antibody detected the SGMS2 protein (arrow). SGMS2 Antibody (C-term) (ABIN653758) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of SGMS2 Antibody (C-term) (ABIN653696) in HepG2 cell line lysates (35 µg/lane). SGMS2 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of SGMS2 Antibody (C-term) (ABIN653696) in mouse spleen tissue lysates (35 µg/lane). SGMS2 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details

SGMS2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Mouse (Murine)


Rat (Rattus)


Top referenced anti-Sphingomyelin Synthase 2 Antibodies

  1. Human Polyclonal Sphingomyelin Synthase 2 Primary Antibody for EIA, FACS - ABIN954780 : Ternes, Brouwers, van den Dikkenberg, Holthuis: Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase. in Journal of lipid research 2009 (PubMed)
    Show all 6 references for ABIN954780

  2. Human Polyclonal Sphingomyelin Synthase 2 Primary Antibody for EIA, WB - ABIN954781 : Liu, Zhang, Li, Hailemariam, Chakraborty, Jiang, Qiu, Bui, Peake, Kuo, Wadgaonkar, Cao, Jiang: Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice. in Arteriosclerosis, thrombosis, and vascular biology 2009 (PubMed)
    Show all 3 references for ABIN954781

  3. Human Polyclonal Sphingomyelin Synthase 2 Primary Antibody for EIA, WB - ABIN265116 : Huitema, van den Dikkenberg, Brouwers, Holthuis: Identification of a family of animal sphingomyelin synthases. in The EMBO journal 2004 (PubMed)

  4. Chicken Polyclonal Sphingomyelin Synthase 2 Primary Antibody for WB - ABIN2785218 : Ding, Li, Hailemariam, Mukherjee, Maxfield, Wu, Jiang: SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis. in Journal of lipid research 2008 (PubMed)

More Antibodies against Sphingomyelin Synthase 2 Interaction Partners

Human Sphingomyelin Synthase 2 (SGMS2) interaction partners

  1. F-actin polymerization in the region of HIV-1 membrane fusion was more prominent in Sms2-expressing cells than Sms (show SMS Antibodies)-deficient cells.

  2. SMS1 (show SGMS1 Antibodies) and SMS2 are capable of regulating TGN (show TG Antibodies)-mediated protein trafficking and secretion

  3. Data indicate that the increased sphingomyelin mass was due to a rapid and highly specific activation of sphingomyelin synthases SMS1 (show SGMS1 Antibodies) and SMS2.

  4. direct morphological evidence for the pro-atherogenic capabilities of sphingomyelin synthase 2

  5. Data show that SMS2 acting as a bifunctional enzyme with both SM and CPE synthase activity.

  6. Data show that sphingomyelin synthases SMS1 (show SGMS1 Antibodies) and SMS2 are co-expressed in a variety of cell types and function as the key Golgi- and plasma membrane-associated SM synthases in human cervical carcinoma HeLa cells, respectively.

  7. Results indicate that both synthase (SMS)1 (show SGMS1 Antibodies) and 2 contribute to sphingomyelin (SM) de novo synthesis and control SM levels in the cells and on the cell membrane including plasma membrane.

  8. SMS2 is a key factor in control of sphingomyelin and diacylglycerol metabolism within the cell, and thus it influences apoptosis.

  9. SMS2 regulates subcellular pools of diacylglycerol-binding proteins in the Golgi apparatus.

  10. SMS2 (Sphingomyelin synthase 2) physiologically contributes to de novo Sphingomyelin biosynthesis and plasma membrane Sphingomyelin levels

Mouse (Murine) Sphingomyelin Synthase 2 (SGMS2) interaction partners

  1. Study provides a mouse model for fetal alcohol spectrum disorder. Due to the accumulation of ceramide in vivo, SMS2 knockout mice allows to investigate how ceramide regulates alcohol-induced neural apoptosis.

  2. study provided evidence that genetic inhibition of SMS2 elevated glucose clearance through activation of glucose uptake into insulin (show INS Antibodies)-targeted tissues such as skeletal muscle by a mechanism independent of hepatic SMS2

  3. Thus, imaging mass spectrometry can provide visual assessment of the contribution of SMS2 on acyl-chain- and region-specific sphingomyelin metabolism in the kidneys

  4. study reveals that all mouse SMS family members (SMSr, SMS1, and SMS2) have CPE synthase activity

  5. Increasing ceramide levels in the liver can be achieved by SMS2 inhibition to prevent liver steatosis via PPARgamma (show PPARG Antibodies) suppression.

  6. Data show that LCAT (show LCAT Antibodies) activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2 (show SPTLC2 Antibodies))+/- and sphingomyelin synthase 2 (Sms2)-/- mice, but markedly lower in ApoE (show APOE Antibodies)-/- and Ldlr (show LDLR Antibodies)-/- mice.

  7. SMS2 deficiency decreases atherosclerosis and inhibits inflammation in mice.

  8. Defects in the stria vascularis with reductions in endocochlear potentials together with hair cell dysfunction may account, at least partially, for hearing impairments in SMS1 (show SGMS1 Antibodies)-/- mice.

  9. SMS2 over-expression was probably associated with increased expression of aortic inflammatory biomarkers, as well as decreased numbers of CD34 (show CD34 Antibodies)/KDR (show KDR Antibodies)-positive cells, CACs and CFUs in circulation

  10. Ablation of CerS2 (show CERS2 Antibodies) causes changes in intrinsic membrane curvature, leading to strong morphological alterations that promote vesicle adhesion, membrane fusion, and tubule formation.

Sphingomyelin Synthase 2 (SGMS2) Antigen Profile

Protein Summary

Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.

Gene names and symbols associated with SGMS2

  • sphingomyelin synthase 2 (sgms2) antibody
  • sphingomyelin synthase 2 (SGMS2) antibody
  • sphingomyelin synthase 2 (Sgms2) antibody
  • 4933405A16Rik antibody
  • 5133401H06Rik antibody
  • AI854299 antibody
  • RGD1305778 antibody
  • SMS2 antibody
  • spermatin antibody

Protein level used designations for SGMS2

sphingomyelin synthase 2 , phosphatidylcholine:ceramide cholinephosphotransferase 2 , phosphatidylcholine:ceramide cholinephosphotransferase 2-like , SM synthase

GENE ID SPECIES
496853 Xenopus (Silurana) tropicalis
695947 Macaca mulatta
735414 Pan troglodytes
100072971 Equus caballus
100079264 Ornithorhynchus anatinus
100400486 Callithrix jacchus
100446194 Pongo abelii
100466473 Ailuropoda melanoleuca
100593842 Nomascus leucogenys
166929 Homo sapiens
556193 Danio rerio
422529 Gallus gallus
478505 Canis lupus familiaris
100518796 Sus scrofa
520954 Bos taurus
74442 Mus musculus
310849 Rattus norvegicus
100715504 Cavia porcellus
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