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The protein encoded by SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. Additionally we are shipping Sphingomyelin phosphodiesterase 1, Acid Lysosomal Antibodies (67) and Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins (11) and many more products for this protein.
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Human SMPD1 ELISA Kit for Sandwich ELISA - ABIN365016
Zhu, Yoshimoto, Yamashima: Heat shock protein 70.1 (Hsp70.1) affects neuronal cell fate by regulating lysosomal acid sphingomyelinase. in The Journal of biological chemistry 2014
results provide evidence that translocated lysosomal V1 H(+)-ATPase (show ATP6AP1 ELISA Kits) contributes to formation of local acid microenvironment to facilitate activation of ASM and consequent membrane raft(MR) aggregation, forming MR redox signalosomes and mediating redox signaling in coronary endothelial cells
Acid sphingomyelinase activation serves as a triggering mechanism, leading to fusion of membrane proximal lysosomes into lipid rafts clusters on the cell membrane of coronary arterial endothelial cells.
Report lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells.
ASM activation may be involved in the pathophysiology of Kawasaki disease
These results indicate that increased EGR1 (show EGR1 ELISA Kits)/3 and ASMase expression play an important role in cellular ceramide increase by RSV treatment.
The results of this study suggested that disruptive mutations in SMPD1 constitute a risk factor for parkindon disease.
This is the first evidence that supports the possibility that sphingolipid metabolism is affected via the induction of ASMase by the Nrf2 (show GABPA ELISA Kits) pathway.
ASM has a pivotal role in adaptive immune T-cell responses.
Patterns of alternatively spliced SMPD1 transcripts are significantly different in patients with systemic inflammatory response syndrome and severe sepsis/septic shock compared to control subjects allowing discrimination of respective disease entity.
The mechanisms by which pyocyanin induces the release of mitochondrial ROS (show ROS1 ELISA Kits) and by which ROS (show ROS1 ELISA Kits) induce neutrophil death via mitochondrial acid sphingomyelinase was identified.
Results show four novel mutations in SMPD1 in Iranian patients with type A or B Niemann-Pick disease extending the genotypic spectrum of the disease.
The relationship between autophagy and A-SMase. [Review]
Data suggest ASM (acid sphingomyelinase) activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2 (show NPC2 ELISA Kits) (Niemann Pick protein type C2); hydrolysis of sphingomyelin by ASM may be crucial for endosomal lipid degradation/sorting.
The reduction of membrane sphingomyelin (SM)is due to transcriptional upregulation of neutral sphingomyelinase (show SMPD2 ELISA Kits) (NSM) through active RhoA (show RHOA ELISA Kits).
Intravenous injection of B16F10 melanoma cells into wild-type mice resulted in multiple lung metastases, while Asm-deficient mice (Smpd1(-/-) mice) were protected from pulmonary tumor spread.
Acid sphingomyelinase deficiency reduces S. aureus-induced lung edema.
Ceramide production in M-CSF (show CSF1R ELISA Kits)-deprived macrophages arises from a combination of ASMase activity and de novo synthesis.
aSMase-deficient mouse is the first example in which microglial lipid inclusions are directly related to a loss of retinal function
ASMase deficiency determined resistance to hepatic steatosis mediated by a high fat diet.
results provide the mechanism for dysferlin (show DYSF ELISA Kits)-mediated repair of skeletal muscle sarcolemma and identify ASM as a potential therapy for dysferlinopathy
Acid sphingomyelinase (ASM) controls autophagy maturation in smooth muscle cells. ASM maintains smooth muscle cell homeostasis and its contractile phenotype. ASM plays a protective role in smooth muscle dysfunction and atherosclerosis.
The action of A-SMase is mediated by the activation of the extracellular signal-regulated kinase, the subsequent proteasomal degradation of the Microphtalmia-associated transcription factor (Mitf (show MITF ELISA Kits)).
These results reveal a novel mechanism of ASM pathogenesis in Alzheimer's disease.
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.
, acid sphingomyelinase
, sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase)
, sphingomyelin phosphodiesterase 1, acid lysosomal
, sphingomyelin phosphodiesterase 1
, sphingomyelin phosphodiesterase-like