Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) ELISA Kits

The protein encoded by SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. Additionally we are shipping Sphingomyelin phosphodiesterase 1, Acid Lysosomal Antibodies (71) and Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins (12) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SMPD1 6609 P17405
SMPD1 20597 Q04519
SMPD1 308909  
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Top Sphingomyelin phosphodiesterase 1, Acid Lysosomal ELISA Kits at antibodies-online.com

Showing 10 out of 31 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.31 ng/mL 1.25-80 ng/mL Typical standard curve 96 Tests Log in to see 13 to 16 Days
$1,026.67
Details
Rabbit 0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Guinea Pig 0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Chicken 4.688 ng/mL 7.813-500 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Monkey 0.188 ng/mL 0.313-20 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Pig 0.188 ng/mL 0.313-20 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Mouse 0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Rat 0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Dog 0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Cow 0.1 ng/mL 5.0-100 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details

Top referenced Sphingomyelin phosphodiesterase 1, Acid Lysosomal ELISA Kits

  1. Human SMPD1 ELISA Kit for Sandwich ELISA - ABIN365016 : Zhu, Yoshimoto, Yamashima: Heat shock protein 70.1 (Hsp70.1) affects neuronal cell fate by regulating lysosomal acid sphingomyelinase. in The Journal of biological chemistry 2014 (PubMed)

More ELISA Kits for Sphingomyelin phosphodiesterase 1, Acid Lysosomal Interaction Partners

Cow (Bovine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. results provide evidence that translocated lysosomal V1 H(+)-ATPase (show ATP6AP1 ELISA Kits) contributes to formation of local acid microenvironment to facilitate activation of ASM and consequent membrane raft(MR) aggregation, forming MR redox signalosomes and mediating redox signaling in coronary endothelial cells

  2. Acid sphingomyelinase activation serves as a triggering mechanism, leading to fusion of membrane proximal lysosomes into lipid rafts clusters on the cell membrane of coronary arterial endothelial cells.

  3. Report lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells.

Human Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. ASM and ceramides, together with STX6 (show STX6 ELISA Kits) and cholesterol, constitute a new regulatory mechanism for the exit of Met from the Golgi during its biosynthetic route.

  2. the p.Ala359Asp mutation causes structural alterations in the hydrophobic environment where ASM is located, decreasing its enzymatic activity

  3. Airway cells with lower SMPD1 activity increases neutrophil chemotaxis towards them.

  4. The results identify acid sphingomyelinase as a novel target of Lycium Chinense berries to decrease saturated/unsaturated fatty acid sphingomyelin ratio, known to be useful for cell health. Consistent with these data, the berries regulate specifically gene expression to protect cells from apoptosis.

  5. ASMase mediated the 50-Hz MF-induced EGFR (show EGFR ELISA Kits) clustering via ceramide which was produced from hydrolyzation on lipid rafts

  6. acid sphingomyelinase-1

  7. ASM is a negative regulator of regulatory T Cell development.

  8. We report on an infant with a new frameshift mutation (c.575dupG) of the SMPD1 gene.

  9. Seven novel mutations (c.518-519insT, c.562_563insC, c.792Gdel, c.949G>A, c.1487_1499delACCGTGTGTACCA, c.1495T>C and c.1670T>C) of the SMPD1 gene were identified in four patients. Only one fetus had two mutations of the SMPD1 gene of amniocytes

  10. although ebeta,5alpha,6beta-triol is more specific than 7-KC, it has been found to be significantly elevated in patients with Niemann-Pick type A, a lysosomal storage disorder caused by mutations in the SMPD1 gene

Mouse (Murine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. this study shows that Asm-deficient mice develop brain measles virus infection that is consistent with an enhanced Treg frequency and/or activity

  2. K8/K18 (show KRT18 ELISA Kits)-dependent PKCdelta (show PKCd ELISA Kits)- and ASMase-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (show KRT18 ELISA Kits) loss.

  3. Aged platelets elicit lung injury in primed recipient mice, which can be alleviated by pharmacological inhibition or genetic deletion of acid sphingomyelinase.

  4. Transgenic ASM female, but not male, mice showed an impaired social preference and a depressive- and anxiogenic-like phenotype, which could be normalized by amitriptyline treatment.

  5. this study shows decreased T cell numbers in Asm-deficient, burn-injured, and microbiota-depleted mice

  6. These findings indicate a novel pathway in tumor metastasis, i.e., tumor cell mediated activation of P-selectin (show SELP ELISA Kits) in platelets, followed by activation and secretion of Asm and in turn release of ceramide and tumor metastasis. The data suggest that p38 MAPK (show MAPK14 ELISA Kits) acts downstream from P-selectin (show SELP ELISA Kits) and is necessary for the secretion of Asm.

  7. Inhibition of ASM in diabetic CACs improved membrane fluidity and homing of these cells to damaged retinal vessels. Collectively, these findings indicate that selective modulation of sphingolipid metabolism in BM-derived cell populations in diabetes normalizes the reparative/proinflammatory cell balance and can be explored as a novel therapeutic strategy for treating diabetic retinopathy.

  8. Inhibition of the smpd1 by antidepressants prevents stress-induced phosphorylation/activation of p38K indicating that antidepressants indirectly target p38K via the acid sphingomyelinase/ceramide system.

  9. The reduction of membrane sphingomyelin (SM)is due to transcriptional upregulation of neutral sphingomyelinase (show SMPD2 ELISA Kits) (NSM) through active RhoA (show RHOA ELISA Kits).

  10. Intravenous injection of B16F10 melanoma cells into wild-type mice resulted in multiple lung metastases, while Asm-deficient mice (Smpd1(-/-) mice) were protected from pulmonary tumor spread.

Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Antigen Profile

Antigen Summary

The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with SMPD1

  • sphingomyelin phosphodiesterase (AaeL_AAEL003402) antibody
  • acid sphingomyelinase (ASM) antibody
  • acid sphingomyelinase (AFUA_4G06640) antibody
  • sphingomyelin phosphodiesterase 1, acid lysosomal (SMPD1) antibody
  • sphingomyelin phosphodiesterase 1 (SMPD1) antibody
  • sphingomyelin phosphodiesterase 1, acid lysosomal (Smpd1) antibody
  • A-SMase antibody
  • Afu4g06640 antibody
  • ASM antibody
  • aSMase antibody
  • NPD antibody
  • SMPD1 antibody
  • Zn-SMase antibody

Protein level used designations for SMPD1

sphingomyelin phosphodiesterase , acid sphingomyelinase , sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) , sphingomyelin phosphodiesterase 1, acid lysosomal , sphingomyelin phosphodiesterase 1 , sphingomyelin phosphodiesterase-like , aSMase

GENE ID SPECIES
5578088 Aedes aegypti
280724 Bos taurus
3509254 Aspergillus fumigatus Af293
450990 Pan troglodytes
711248 Macaca mulatta
100030863 Monodelphis domestica
100172518 Pongo abelii
100307047 Ovis aries
100353898 Oryctolagus cuniculus
100400920 Callithrix jacchus
6609 Homo sapiens
485334 Canis lupus familiaris
505097 Bos taurus
20597 Mus musculus
308909 Rattus norvegicus
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