Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins (SMPD1)

The protein encoded by SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. Additionally we are shipping Sphingomyelin phosphodiesterase 1, Acid Lysosomal Antibodies (71) and Sphingomyelin phosphodiesterase 1, Acid Lysosomal Kits (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMPD1 6609 P17405
SMPD1 20597 Q04519
Rat SMPD1 SMPD1 308909  
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Top Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Baculovirus infected Insect Cells Mouse His tag 20 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$640.00
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$785.40
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HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
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HOST_Baculovirus infected Insect Cells Human His tag SDS-PAGE 50 μg Log in to see 20 to 21 Days
$612.15
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Yeast REACT_Tick His tag   1 mg Log in to see 60 to 71 Days
$2,942.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$845.63
Details

SMPD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine) ,

Top referenced Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins

  1. Human SMPD1 Protein expressed in Baculovirus infected Insect Cells - ABIN2003951 : Lansmann, Schuette, Bartelsen, Hoernschemeyer, Linke, Weisgerber, Sandhoff: Human acid sphingomyelinase. in European journal of biochemistry / FEBS 2003 (PubMed)

More Proteins for Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Interaction Partners

Cow (Bovine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. results provide evidence that translocated lysosomal V1 H(+)-ATPase (show ATP6AP1 Proteins) contributes to formation of local acid microenvironment to facilitate activation of ASM and consequent membrane raft(MR) aggregation, forming MR redox signalosomes and mediating redox signaling in coronary endothelial cells

  2. Acid sphingomyelinase activation serves as a triggering mechanism, leading to fusion of membrane proximal lysosomes into lipid rafts clusters on the cell membrane of coronary arterial endothelial cells.

  3. Report lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells.

Human Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. ASM and ceramides, together with STX6 (show STX6 Proteins) and cholesterol, constitute a new regulatory mechanism for the exit of Met from the Golgi during its biosynthetic route.

  2. the p.Ala359Asp mutation causes structural alterations in the hydrophobic environment where ASM is located, decreasing its enzymatic activity

  3. Airway cells with lower SMPD1 activity increases neutrophil chemotaxis towards them.

  4. The results identify acid sphingomyelinase as a novel target of Lycium Chinense berries to decrease saturated/unsaturated fatty acid sphingomyelin ratio, known to be useful for cell health. Consistent with these data, the berries regulate specifically gene expression to protect cells from apoptosis.

  5. ASMase mediated the 50-Hz MF-induced EGFR (show EGFR Proteins) clustering via ceramide which was produced from hydrolyzation on lipid rafts

  6. acid sphingomyelinase-1

  7. ASM is a negative regulator of regulatory T Cell development.

  8. We report on an infant with a new frameshift mutation (c.575dupG) of the SMPD1 gene.

  9. Seven novel mutations (c.518-519insT, c.562_563insC, c.792Gdel, c.949G>A, c.1487_1499delACCGTGTGTACCA, c.1495T>C and c.1670T>C) of the SMPD1 gene were identified in four patients. Only one fetus had two mutations of the SMPD1 gene of amniocytes

  10. although ebeta,5alpha,6beta-triol is more specific than 7-KC, it has been found to be significantly elevated in patients with Niemann-Pick type A, a lysosomal storage disorder caused by mutations in the SMPD1 gene

Mouse (Murine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. this study shows that Asm-deficient mice develop brain measles virus infection that is consistent with an enhanced Treg frequency and/or activity

  2. K8/K18 (show KRT18 Proteins)-dependent PKCdelta (show PKCd Proteins)- and ASMase-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (show KRT18 Proteins) loss.

  3. Aged platelets elicit lung injury in primed recipient mice, which can be alleviated by pharmacological inhibition or genetic deletion of acid sphingomyelinase.

  4. Transgenic ASM female, but not male, mice showed an impaired social preference and a depressive- and anxiogenic-like phenotype, which could be normalized by amitriptyline treatment.

  5. this study shows decreased T cell numbers in Asm-deficient, burn-injured, and microbiota-depleted mice

  6. These findings indicate a novel pathway in tumor metastasis, i.e., tumor cell mediated activation of P-selectin (show SELP Proteins) in platelets, followed by activation and secretion of Asm and in turn release of ceramide and tumor metastasis. The data suggest that p38 MAPK (show MAPK14 Proteins) acts downstream from P-selectin (show SELP Proteins) and is necessary for the secretion of Asm.

  7. Inhibition of ASM in diabetic CACs improved membrane fluidity and homing of these cells to damaged retinal vessels. Collectively, these findings indicate that selective modulation of sphingolipid metabolism in BM-derived cell populations in diabetes normalizes the reparative/proinflammatory cell balance and can be explored as a novel therapeutic strategy for treating diabetic retinopathy.

  8. Inhibition of the smpd1 by antidepressants prevents stress-induced phosphorylation/activation of p38K indicating that antidepressants indirectly target p38K via the acid sphingomyelinase/ceramide system.

  9. The reduction of membrane sphingomyelin (SM)is due to transcriptional upregulation of neutral sphingomyelinase (show SMPD2 Proteins) (NSM) through active RhoA (show RHOA Proteins).

  10. Intravenous injection of B16F10 melanoma cells into wild-type mice resulted in multiple lung metastases, while Asm-deficient mice (Smpd1(-/-) mice) were protected from pulmonary tumor spread.

Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Protein Profile

Protein Summary

The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with SMPD1

  • sphingomyelin phosphodiesterase (AaeL_AAEL003402)
  • acid sphingomyelinase (ASM)
  • acid sphingomyelinase (AFUA_4G06640)
  • sphingomyelin phosphodiesterase 1, acid lysosomal (SMPD1)
  • sphingomyelin phosphodiesterase 1 (SMPD1)
  • sphingomyelin phosphodiesterase 1, acid lysosomal (Smpd1)
  • A-SMase protein
  • Afu4g06640 protein
  • ASM protein
  • aSMase protein
  • NPD protein
  • SMPD1 protein
  • Zn-SMase protein

Protein level used designations for SMPD1

sphingomyelin phosphodiesterase , acid sphingomyelinase , sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) , sphingomyelin phosphodiesterase 1, acid lysosomal , sphingomyelin phosphodiesterase 1 , sphingomyelin phosphodiesterase-like , aSMase

GENE ID SPECIES
5578088 Aedes aegypti
280724 Bos taurus
3509254 Aspergillus fumigatus Af293
450990 Pan troglodytes
711248 Macaca mulatta
100030863 Monodelphis domestica
100172518 Pongo abelii
100307047 Ovis aries
100353898 Oryctolagus cuniculus
100400920 Callithrix jacchus
6609 Homo sapiens
485334 Canis lupus familiaris
505097 Bos taurus
20597 Mus musculus
308909 Rattus norvegicus
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